Publications by authors named "Lennart Th Jacobsson"
Article Synopsis
- The study aimed to determine if levels of cartilage oligomeric matrix protein (COMP) and patient characteristics can predict cardiovascular disease (CVD) risk in early rheumatoid arthritis (RA) patients.
- In a cohort of 233 early RA patients, results showed that higher COMP levels and traditional risk factors like age and hypertension were linked to an increased risk of CVD.
- Active disease status two years after diagnosis and the total disease activity also contributed to a higher risk of CVD and coronary artery disease (CAD).
Background: Excess mortality in gout has been attributed to cardiovascular diseases (CVD). Considering the decline in CVD mortality in the general population, we wanted to evaluate overall mortality in gout and cause-specific contributions to mortality beyond CVD and temporal trends.
Methods: All incident cases of gout between 2006 and 2015 in western Sweden and 5 population controls per case matched for age, sex, and county were identified.
Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration.
Ann Rheum Dis
November 2021
Article Synopsis
- Comedication with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) during tumor necrosis factor inhibitor (TNFi) treatment in psoriatic arthritis (PsA) is common, but its added benefits were unclear prior to this study.
- The study analyzed data from over 15,000 PsA patients across 13 European countries, comparing those on csDMARDs alongside TNFi treatment versus those on TNFi alone, finding that comedication was linked to better remission rates overall.
- Specifically, methotrexate used with adalimumab and infliximab led to increased remission rates, while no significant effects were observed for etanercept when used in combination with csDM
The yield of a positive MRI of the spine as imaging criterion in the ASAS classification criteria for axial spondyloarthritis: results from the SPACE and DESIR cohorts.
Ann Rheum Dis
October 2017
Objectives: To assess the prevalence of spinal inflammation on MRI in patients with chronic back pain (CBP) of maximally 3 years duration and to evaluate the yield of adding a positive MRI-spine as imaging criterion to the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA).
Methods: Baseline imaging of the sacroiliac joints (X-SI), MRI of the sacroiliac joints (MRI-SI) and MRI-spine were scored by ≥2 experienced central readers per modality in the SPondyloArthritis Caught Early (SPACE) and DEvenir des Spondylarthropathies Indifférenciées Récentes (DESIR) cohorts. Inflammation suggestive of axSpA was assessed in the entire spine.
Introduction: Environmental exposures, including smoking, hormone-related factors, and metabolic factors, have been implicated in the etiology of rheumatoid arthritis (RA). A previous study has indicated that blood lipid levels may influence the development of RA. The objective of this study was to investigate the impact of serum total cholesterol and triglycerides on the risk of RA in a prospective study.
View Article and Find Full Text PDFObjectives: Information on mortality in ankylosing spondylitis (AS) is scarce. Our study therefore aimed to assess: (1) mortality in AS versus the general population, and (2) predictors of death in the AS population.
Methods: Nationwide cohorts of patients with AS diagnosed at rheumatology or internal medicine outpatient clinics (n=8600) and age-matched, sex-matched and county-matched general population comparators (n=40 460) were identified from the National Patient Register and the census register, respectively.
Objective: To explore how people with rheumatoid arthritis (RA) perceive leisure activities.
Method: A phenomenographic approach using semi-structured interviews to explore the impact of RA on leisure pursuits was used.
Results: Three descriptive categories containing 11 conceptions emerged: (1) Experiencing constraints included four conceptions: seeing limitations, needing time, finding balance, being dependent.