In vivo endocultivation of CAD/CAM hybrid scaffolds in the omentum majus in miniature pigs.

Purpose: Correction of bony mandibular defects is a challenge in oral and maxillofacial surgery due to aesthetic and functional requirements. This study investigated the potential of a novel hybrid scaffold for bone regeneration and degradation assessment of the ceramic within the omentum majus over 6 months and the extent to which rhBMP-2 as a growth factor, alone or combined with a hydrogel, affects regeneration.

Materials And Methods: In this animal study, 10 Göttingen minipigs each had one scaffold implanted in the greater omentum.