Publications by authors named "Lenggenhager L"
Article Synopsis
- The study investigated how both work-related and community exposures contributed to SARS-CoV-2 infections among staff at a long-term care facility in Switzerland during the early phase of the pandemic (March-June 2020).
- Researchers analyzed seroprevalence data from volunteer employees and studied transmission dynamics during a COVID-19 outbreak, identifying factors related to seropositivity and the genetic similarities of virus strains.
- Results showed that out of 176 participants, 17% tested positive, with exposure to COVID-19 patients and community cases being significant risk factors, highlighting the crucial role of both work and community interactions in spreading the virus among healthcare workers.
Article Synopsis
- - The study aimed to assess how many patients diagnosed with Clostridium difficile infection (CDI) received treatment despite having discordant test results (positive NAAT and negative EIA) and to find patient traits linked to treatment decisions.
- - Conducted in a tertiary care hospital in Geneva, Switzerland, the study focused on 208 adult patients out of 4,562 tested between March 2017 and March 2019.
- - Results showed that 71% of these patients received CDI treatment, and an abdominal CT scan indicating colitis was the main factor influencing the decision to treat, raising questions about the role of certain diagnostic tests in preventing overtreatment.
Article Synopsis
- Meningitis, encephalitis, and myelitis are serious forms of CNS inflammation that often have unknown causes, with around 50% of cases remaining unexplained despite medical advancements.
- Researchers conducted high-throughput sequencing on CSF samples from patients with acute CNS inflammation to identify potential viral causes, discovering one case related to human astrovirus while other findings were linked to harmless infections or contamination.
- The study emphasizes the promise of high-throughput sequencing for discovering unknown viral pathogens in CNS diseases, but also points out challenges in accurately interpreting these results in clinical settings.
Background: Viral aetiologies are the most common cause of central nervous system (CNS) infections. Approximately one-half of CNS infections remain of undetermined origin. High-throughput sequencing (HTS) brought new perspectives to CNS infection investigations, allowing investigation of viral aetiologies with an unbiased approach.
View Article and Find Full Text PDFObjectives: Therapeutic drug monitoring (TDM) of beta-lactam antibiotics is increasingly employed to ensure adequate antibiotic exposure and slow emergence of resistance. Imipenem's therapeutic range has not been defined; we report plasma concentrations and clinical outcomes of patients receiving imipenem for bacterial infections.
Methods: All hospitalized adult patients undergoing imipenem TDM during therapy for suspected or confirmed bacterial infections between 1 January 2013 and 28 February 2017 were included in this single-centre retrospective cohort.
Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study.
Clin Microbiol Infect
July 2017
Objectives: Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it. Therapeutic drug monitoring (TDM) of β-lactam antibiotics is increasing, but optimal plasma concentrations remain unknown. We examined clinical outcomes of patients undergoing cefepime TDM in an initial effort to define the drug's toxicity threshold.
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