Aerobic Exercise Training, Biological Age, and Mortality in Chronic Heart Failure With Reduced Ejection Fraction.

Background: Among individuals with chronic heart failure with reduced ejection fraction (HFrEF), the predictive value for mortality by biomarker-based biological age (BA) and whether aerobic exercise training (AET) modifies the association are understudied.

Objectives: The authors aimed to investigate the association between BA and mortality among individuals with HFrEF and assess whether AET modifies the association.

Methods: Including participants in HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training), BA acceleration was constructed by the Klemera-Doubal method, using the residual of a linear model of BA and chronological age.

design of a mechano-pharmaceutical screening platform against formation of individual beta-amyloid oligomers.

Small molecules that can reduce the neurotoxic beta-amyloid (Aβ) aggregates in the brain provide a potential treatment for Alzheimer disease (AD). Most screening methods for small-molecule hits focus on the overall Aβ aggregations without a specific target, such as the very first association step (i.e.

Genomic characterization and antifungal properties of YF, a promising biocontrol agent against pathogen of codonopsis root rot.

Root rot, a destructive soil-borne disease, poses a significant threat to a wide range of economically important crops. Codonopsis, a high-value medicine plant, is particularly susceptible to substantial production losses caused by -induced root rot. In this study, we identified a promising biocontrol agent for codonopsis root rot, YF.

Gold nanocubes etching enhanced light scattering immunoassay for highly sensitive detection of Staphylococcus aureus enterotoxin A.

An innovative light scattering immunoassay was developed using an AuNPs etching strategy. Three types of anisotropic gold nanoparticles, including gold nanocubes, nanorods, and nanoflowers with distinct morphologies, were utilized to investigate how these morphological differences affect the sensitivity of light scattering signal transduction. Based on theoretical insights into light scattering and electromagnetic fields, gold nanocubes were identified as the optimal probes for enhancing light scattering signal transduction and were employed to construct an immunoassay for detecting staphylococcal enterotoxin A (SEA).

New insights into tRNA-derived small RNAs in human digestive diseases.

tRNA-derived small RNAs (tsRNAs) is a type of non-coding RNA that is present in large quantities in humans and exhibits high stability. It plays a crucial role in various physiological processes and diseases. In recent years, research on tsRNAs in tumors has expanded significantly, revealing its regulatory effects in non-neoplastic diseases as well.

Fluorine-modified passivator for efficient vacuum-deposited pure-red perovskite light-emitting diodes.

Vacuum-deposited perovskite light-emitting diodes (PeLEDs) have demonstrated significant potential for high-color-gamut active-matrix displays. Despite the rapid advance of green PeLEDs, red ones remain a considerable challenge because of the inferior photophysical properties of vacuum-deposited red-light-emitting materials. Here, a rationally designed fluorine-modified phosphine oxide additive was introduced to in-situ passivate vacuum-deposited perovskites.

Association between the oxidative balance score and testosterone deficiency: a cross-sectional study of the NHANES, 2011-2016.

There is increasing recognition of the role of oxidative balance in testosterone deficiency (TD). This study investigates the association between the oxidative balance score (OBS) and TD prevalence among adult males in the United States. Data were obtained from a cross-sectional study of 3276 adult men in the 2011-2016 National Health and Nutrition Examination Survey.

Efficacy of perioperative dexmedetomidine on postoperative pain and neurocognitive functions in orthopaedic surgery: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.

Introduction: With an estimated 2.1 million hip and knee replacements performed annually in developed countries, orthopaedic surgeries can result in complications such as postoperative pain and cognitive dysfunctions. Dexmedetomidine shows potential for reducing pain and opioid use and improving cognitive outcomes, but its efficacy in orthopaedic settings needs further evaluation.

Decouple and Couple: Exploiting Prior Knowledge for Visible Video Watermark Removal.

This paper aims to restore original background images in watermarked videos, overcoming challenges posed by traditional approaches that fail to handle the temporal dynamics and diverse watermark characteristics effectively. Our method introduces a unique framework that first "decouples" the extraction of prior knowledge-such as common-sense knowledge and residual background details-from the temporal modeling process, allowing for independent handling of background restoration and temporal consistency. Subsequently, it "couples" these extracted features by integrating them into the temporal modeling backbone of a video inpainting (VI) framework.

Uncertainty-Guided Discriminative Priors Mining for Flexible Unsupervised Spectral Reconstruction.

Existing supervised spectral reconstruction (SR) methods adopt paired RGB images and hyperspectral images (HSIs) to drive the overall paradigms. Nonetheless, in practice", paired" requires higher device requirements such as specific well-calibrated dual cameras or more complex and exact registration processes among images with different time phases, widths, and spatial resolution. To tackle the above challenges, we propose a flexible uncertainty-aware unsupervised SR paradigm, which dynamically establishes the forceful and potent constraints with RGBs for driving unsupervised learning.

Decoding SSVEP Via Calibration-Free TFA-Net: A Novel Network Using Time-Frequency Features.

Brain-computer interfaces (BCIs) based on steady-state visual evoked potential (SSVEP) signals offer high information transfer rates and non-invasive brain-to-device connectivity, making them highly practical. In recent years, deep learning techniques, particularly convolutional neural network (CNN) architectures, have gained prominence in EEG (e.g.

Hua Zheng San Ji Fang suppresses liver cancer progression by inhibiting TYRO3 expression via the ERK signaling pathway.

Background: Liver cancer poses a significant global health challenge owing to its increasing incidence and associated mortality rates. Traditional Chinese Medicine (TCM) has garnered attention for its potential in oncology, with formulations such as Hua Zheng San Ji Fang (HZSJF) exhibiting antineoplastic effects. HZSJF is clinically employed in China for cancer treatment; however, its molecular mechanisms in liver cancer remain elusive.

Magnetic Prussian blue nanoparticles to enhance dual-readout lateral flow immunoassay for Salmonella typhimurium detection.

Background: Traditional immunochromatographic assay (ICA) test strips typically utilize colloidal gold nanoparticles as colorimetric signal reporters, but they often suffer from compromised sensitivity and quantitative accuracy, making them inadequate for the stringent demands of trace-level screening. In addition, the heterogeneous nature of food matrices, such as dairy products, meat, and ready-to-eat fruits and vegetables, complicates the accuracy and reliability of ICA for detecting foodborne pathogens. Therefore, enhancing the detection accuracy of ICA is critical to meet the stringent requirements for pathogen detection in complex food samples.

Spin Polarization-Boosting Ultrafast Carrier Dynamics and Exciton Dissociation in Fe Nanoparticle-Loading Graphitic Carbon Nitride Toward Efficient CO Photoreduction.

The regulation of exciton properties plays a crucial role in enhancing the activity of photocatalysts, primarily due to the rapid recombination of photoinduced electron-hole pairs caused by the strong Coulomb interaction between them. In this study, we explore the spin polarization effect in nanohybrids composed of graphitic carbon nitride (g-C₃N₄) and iron (Fe) nanoparticles, which accelerates exciton dissociation and spin-selective electron transfer, thereby improving the selective photoreduction of CO₂ into CO. Mechanistic studies reveal that the Fe⁺/Fe⁺ redox pairs, embedded in the iron oxide layer on the surface of Fe nanoparticles, function as ultrafast charge transfer shuttles via a double exchange interaction (Fe⁺─O─Fe⁺).

The risk factors for type ii respiratory failure in patients with severe scoliosis (less than 40-year old).

Objective: To investigate the risk factors for Type II respiratory failure associated with severe scoliosis in patients under 40 years of age.

Methods: Patients with severe scoliosis and pulmonary impairment treated in our hospital from January 2020 to December 2022 were recorded. We evaluated the spinal parameters in standing full spine X-rays, including the main thoracic curve, thoracic kyphosis, apical vertebrae, and distance between T1-T12.

In Situ NADH-Activated BODIPY-Based Macrocyclic Supramolecular Photosensitizer for Chemo-Photodynamic Synergistic Tumor Therapy.

Photodynamic therapy (PDT) based on supramolecular assembly has been receiving wide attention due to its great potential application in clinical treatment. Herein, we report a supramolecular photoelectron "reservoir" (SPR) constructed by tetracationic boron dipyrromethene (BODIPY)-based macrocycle (4Cl), doxorubicin (Dox), and tumor-targeted β-cyclodextrin-grafted hyaluronic acid (HACD). Upon irradiation, 4Cl can in situ catalyze nicotinamide adenine dinucleotide (NADH) to continuously generate electrons to inject into SPR, which further transfers electrons to oxygen, inducing highly efficient hydroxyl radical generation even under hypoxia.

Neuroanatomical Insights: Convergence and Divergence of Tinnitus with Normal or Mild Hearing Loss.

: To explore the neuroanatomical abnormalities in idiopathic tinnitus patients by voxel-based morphometry (VBM) and surface-based morphometry (SBM) techniques. To elucidate the central plasticity in tinnitus patients with normal or mild hearing loss from the neuroanatomical insights. : A total of 74 patients with idiopathic tinnitus (43 with normal hearing and 31 with mild hearing loss) and 98 healthy subjects were enrolled.

Correction: Fu et al. Synergistic Effect of Combined Walnut Peptide and Ginseng Extracts on Memory Improvement in C57BL/6 Mice and Potential Mechanism Exploration. 2023, , 2329.

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Effects of CPAP on Neuroimaging Biomarkers and Cognition in Adult OSA: A Randomized Controlled Trial.

Rationale: Obstructive sleep apnea (OSA) is associated with cognitive impairment. The effects of continuous positive airway pressure (CPAP) on neuroimaging biomarkers and cognitive performance among middle-aged patients with OSA and normal cognition remain unclear.

Objectives: To investigate the effects of CPAP therapy over 12 months on neuroimaging biomarkers and cognitive performance.

Effect of ultra-high pressure combined with heat-assisted treatment on the characterization, moisture absorption, and antioxidant activity properties of walnut peptide.

In this study, ultra-high pressure (UHP) and heat-assisted technology (HT) were used to process walnut peptides (WP) and investigate their combined effects (UHP-HT) on the characterization, moisture absorption, and antioxidant activity of WP. The results indicated that UHP (300 Mpa, 10 min) combined with HT treatment (55 °C, 30 min) significantly increased the surface hydrophobicity and disulfide bonds of WP. UHP-HT-treated WP exhibited lower moisture absorption and more stable water molecule migration.

Investigation of the oxidation rules and oxidative stability of seabuckthorn fruit oil during storage based on lipidomics and metabolomics.

Seabuckthorn fruit oil (SBFO) is recognized for its high nutritional value, yet it remains highly prone to oxidation during storage. The changes in its primary components and micronutrient molecules during storage have not been thoroughly investigated. This study employed untargeted lipidomics and metabolomics to dynamically monitor alterations in lipid composition and metabolites of SBFO over 30 days of accelerated storage.

The Modulatory Effects of Anesthetics and Analgesics on Neurophysiological Monitoring and Underlying Mechanisms.

Intraoperative Neurophysiological Monitoring (IONM) is an indispensable surgical tool that offers invaluable insights into neurological function across a spectrum of anatomical areas. By comprehensively assessing the integrity of the brain, brainstem, spinal cord, cranial nerves, and peripheral nerves, IONM plays a pivotal role in guiding surgical decision-making and optimizing patient outcomes, particularly in the context of high-risk procedures. Intraoperative drugs, especially anesthetics and/or analgesics, differentially modulate neurophysiological monitoring, which remarkably affects the application of neurophysiological monitoring under specific conditions and indicates the neurobiological mechanisms of anesthetics/analgesics.

Comparison of vHIT deficits with Ramsay Hunt syndrome with dizziness, vestibular neuritis, and idiopathic sudden sensorineural hearing loss with vertigo.

Background: Ramsay Hunt syndrome with dizziness (RHSD), vestibular neuritis (VN), and idiopathic sudden sensorineural hearing loss with vertigo (SHLV) all present with acute vestibular symptoms, and no study has compared the semicircular canal (SCC) deficits among them.

Objective: This study aimed to use video head impulse test (vHIT) to compare the SCC injury patterns in RHSD, VN, and SHLV.

Methods: Twenty-three RHSD patients, 44 VN patients, and 70 SHLV patients were enrolled.

Burn-Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan-Kynurenine Mediated AHR Pathway Activation.

The hypermetabolic response associated with burns is characterized by skeletal muscle atrophy and an increased incidence of disability and death. Significant remodeling of the gut microbiota occurs after severe burn trauma. However, the specific mechanisms by which gut microbiota contribute to burn-induced muscle atrophy remain unexplored.

Inhibition of high glucose-induced cardiac fibroblast activation: an effective treatment for diabetic cardiomyopathy using Chinese herbal medicine.

Diabetic cardiomyopathy (DCM) is one of the common diabetic microangiopathy in clinical practice. In the early stage of the disease, there are no obvious clinical symptoms. In the middle and late stages, MF, arrhythmia, and even heart failure may occur, affecting the life and health of patients.