Clinicopathological characteristics of low-dose methotrexate-induced epidermal dysmaturation: A study of 22 patients.

Background And Objective: Erosions of the skin and mucous membranes with epidermal dysmaturation are a known side effect of cytostatic chemotherapy regimens and can also be observed during low-dose methotrexate (MTX) therapy. The study aimed to delineate the clinical and histopathological alterations.

Patients And Methods: A database search of the archive for dermatopathology was conducted, identifying 22 patients who developed epidermal dysmaturation on low-dose MTX.

An Automated Real-Time PCR Assay versus Next-Generation Sequencing in the Detection of V600 Mutations in Melanoma Tissue Samples.

Background: Next-generation sequencing (NGS) is the most commonly used method for determining mutational status in patients with advanced melanoma. Automated PCR-based methods, such as the Idylla system, are increasingly used for mutation diagnostics, but it is unclear what impact the choice of diagnostic method has on the management of melanoma.

Objectives: To compare the concordance rate of V600 mutational analysis using Idylla and NGS and to analyze the technical and clinical turnaround time.

Treatment of aseptic facial granuloma as a manifestation of pediatric rosacea with oral macrolides.

Aseptic facial granuloma is a rare pediatric disease, presenting with asymptomatic facial nodules on the cheeks or the eyelids and may represent a form of granulomatous rosacea in children. In this retrospective case series, 12 children with aseptic facial granuloma were treated with oral macrolides (erythromycin or roxithromycin) resulting in a healing of the lesions within a mean treatment time of 5.25 months with no recurrences.

Thoracoabdominal motion during chest physiotherapy in patients affected by chronic obstructive lung disease.

In 11 patients suffering from chronic obstructive lung disease, thoracoabdominal movements were monitored with magnetometers during various breathing manoeuvres directed by the chest physiotherapist. The signals derived from the magnetometers and the mouth flow were analysed in order to pick up paradoxical movements of one or the other compartment of the chest wall. In contrast to what was observed during spontaneous breathing, especially abdominodiaphragmatic breathing induced in most of the subjects paradoxical movements.

Low frequency breathing at rest and during exercise in severe chronic obstructive bronchitis.

The effect of low frequency breathing compared with spontaneous breathing was examined at rest and during exercise (40 watts) in 12 patients suffering from severe chronic obstructive bronchitis. At rest low frequency breathing improved significantly the alveolar ventilation and the tensions of oxygen and carbon dioxide in the arterial blood. There was no significant change in ventilation minute volume.