Intracanal delivery of Resolvin E1 controls inflammation in necrotic immature rat teeth.

Introduction: Pulp necrosis in immature teeth and the resulting periodontal apical inflammation negatively affect root formation. Resolvin E1 (RvE1) is a lipid-derived endogenous pro-resolution molecule that controls inflammation. The aim of this investigation was to evaluate the impact of RvE1 applied as an intracanal medication on root formation in nonvital immature teeth.

Apical periodontium response to enamel matrix derivative as an intracanal medication in rat immature teeth with pulp necrosis: radiographic and histologic findings.

Introduction: The aim of this study was to evaluate the enamel matrix derivative (EMD) biomaterial in nonvital immature teeth.

Methods: To arrest root development, pulpectomies were performed in the lower first molars of 36 4-week-old rats; the cavities were left exposed to the oral environment for 3 weeks. Then, chemical disinfection was performed, and triple antibiotic paste (TAP) or EMD was applied in the root canals.

Response to intracanal medication in immature teeth with pulp necrosis: an experimental model in rat molars.

Introduction: The present study aimed at developing an experimental model in rat molars for evaluating treatment strategies in necrotic immature teeth.

Methods: To define the periods to be adopted in the experimental procedures and to confirm induction of periapical lesions and interruption of root embryogenesis, the left lower first molars of 4-weeks-old Wistar rats underwent pulpectomy and were left open to the oral environment. Comparisons with the right lower first molars (vital teeth) were performed in animals with ages of 7, 10, 13, and 16 weeks.