Publications by authors named "Lena Siebe"
Tetradentate-N ligands stabilize dinuclear {Cu(μ-1,2-peroxo)Cu} and {Cu(μ-O)Cu} species, and Cu complexes of these ligands were reported to catalyze the oxidation of benzene with HO. Here, we report {Cu(μ-1,2-peroxo)Cu} and {Cu(μ-O)Cu} intermediates of dinucleating bis(tetradentate-N) ligands depending on the absence or presence of 6-methyl substituents on the terminal pyridine donors, respectively, generated either from {CuCu} precursors with O or from {CuCu} precursors with HO and NEt. Both intermediates are not stable even at low temperatures, but they show no electrophilic HAT reactivity with DHA.
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- Cytostatic metallo-drugs typically bind to DNA nucleobases, but new dinuclear transition metal complexes are designed to target the phosphate diesters of DNA instead.
- The first dinuclear Ni complex shows different DNA binding characteristics compared to a similar Cu complex, leading to lower interference in DNA synthesis, especially in PCR, at lower concentrations.
- Cytotoxicity studies reveal that the Cu complex is more effective in killing cancer cells due to its ability to induce apoptosis, emphasizing the potential of these complexes as innovative anticancer treatments.