Publications by authors named "Lena Russ"
Article Synopsis
- - Schistosomiasis, caused by parasitic worms, affects over 250 million people and primarily impacts the gastrointestinal tract, triggering a specific immune response linked to the formation of granulomas through its eggs.
- - A study on hamsters explored the connection between the number of parasitic eggs and the immune response, analyzing egg load and cytokine expression in liver and colon tissues.
- - Results showed no link between Th1 cytokines and egg load in the liver, while some Th2 cytokines exhibited an unexpected inverse correlation, potentially due to prolonged embryogenesis of eggs in the liver, which didn't occur in the colon.
Background: Spinal muscular atrophy (SMA) is a neuromuscular disease, causing progressive muscle weakness due to loss of lower motoneurons. Since 2017, three therapies, two modifying gene transcription and one adding the defective gene, have been approved with comparable efficacy on motor outcome. Data on cognitive outcomes of treated SMA type 1 patients is limited.
View Article and Find Full Text PDFSchistosoma mansoni-Induced Oxidative Stress Triggers Hepatocellular Proliferation.
Cell Mol Gastroenterol Hepatol
December 2023
Background & Aims: Schistosomiasis is one of the most prominent parasite-induced infectious diseases, affecting more than 250 million people. Schistosoma mansoni causes metabolic exhaustion and a strong redox imbalance in the liver, causing parenchymal damage, and may predispose for cancer. We investigated whether oxidative stress provokes hepatocellular proliferation upon S.
View Article and Find Full Text PDFBackground & Aims: Schistosomiasis is a parasitic infection which affects more than 200 million people globally. eggs, but not the adult worms, are mainly responsible for schistosomiasis-specific morbidity in the liver. It is unclear if eggs consume host metabolites, and how this compromises the host parenchyma.
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