Comprehensive Assessment of the Virulence Factors , and in the Zoonotic Dermatophyte Using FISH and qPCR.

Skin infections by keratinophilic fungi are commonly referred to as dermatophytosis and represent a major health burden worldwide. Although patient numbers are on the rise, data on virulence factors, their function and kinetics are scarce. We employed an ex vivo infection model based on guinea pig skin explants (GPSE) for the zoonotic dermatophyte   to investigate kinetics of the virulence factors subtilisin , , and at gene level for ten days.