Publications by authors named "Lena Krockenberger"
Article Synopsis
- * A new algorithm called OM2BFB was developed to effectively detect BFB amplifications using optical genome maps, achieving high accuracy and recall in identifying these events across various cancer models.
- * BFB amplification tends to occur more in certain cancers (like cervical and lung) and results in lower variability in gene expression compared to ecDNA amplifications, which may indicate different patterns of treatment resistance and offer
Background: Precision medicine incorporating genetic profiling is becoming a standard of care in medical oncology. However, in the field of radiation oncology there is limited use of genetic profiling and the impact of germline genetic biomarkers on radiosensitivity, radioresistance, or patient outcomes after radiation therapy is poorly understood. In HNSCC, the toxicity associated with treatment can cause delays or early cessation which has been associated with worse outcomes.
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