Publications by authors named "Lena Kersting"
The development of a convenient and rapid method to synthesize radiolabeled, enantiomerically pure amino acids (AAs) as potential positron emission tomography (PET) imaging agents for mapping various biochemical transformations in living organisms remains a challenge. This is especially true for the synthesis of carbon-11-labeled AAs given the short half-life of carbon-11 ( C, t =20.4 min).
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- - The western corn rootworm (WCR) is a major pest affecting maize, and breeding for tolerance is a potential solution, but current methods lack sufficient understanding and tools for assessment.
- - Researchers developed advanced techniques like positron emission tomography and radiometabolite flux analysis to study how maize adapts to WCR attacks, revealing specific changes in root growth and auxin biosynthesis.
- - The study found that WCR attacks lead to an increase in certain amino acids and a significant shift in auxin production, suggesting that monitoring these changes could help in breeding corn that is more resilient to this pest.
Carbon-11 (β(+) emitter, t1/2 = 20.4 min) radiolabeled L-glutamine is a potentially useful molecular imaging agent that can be utilized with positron emission tomography for both human oncological diagnosis and plant imaging research. Based upon a previously reported [(11)C]cyanide end-capping labeling method, a systematic investigation of nucleophilic cyanation reactions and acidic hydrolysis reaction parameters, including base, metal ion source, phase transfer catalyst, solvent, reaction temperature and reaction time, was conducted.
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