Publications by authors named "Lena HiddeSSen"
A referencing strategy based on the element P is presented to compensate for cryosectioning tissue artifacts in laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) data. The study examines how the gadolinium-based contrast agent Gadofosveset is distributed in murine cancer tissue, and illustrates how referenced images can compensate for tissue artifacts like folds, overlaps, and density variations. Compared to non-referenced images that provide information on the absolute distribution of the analyte, referenced images allow for the representation of the analyte distribution relative to the amount of material introduced into the instrument, which in this case is correlated to the P signal.
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- - The study aimed to differentiate malignancy levels in two mouse breast cancer models (4T1 and 67NR) using advanced MRI techniques to analyze their tissue characteristics over time.
- - Using a small animal MRI at 9.4 T and various imaging protocols, researchers discovered that the 4T1 tumors displayed greater blood vessel distortion and permeability compared to the more stable and intact blood vessels in the 67NR tumors.
- - Significant differences in tumor composition were noted, with 4T1 tumors showing more heterogeneity and necrotic areas, while 67NR tumors had better blood vessel integrity and a clearer wash-out of contrast agent, indicating varying degrees of malignancy.