Publications by authors named "Lena Avinery"
Cancers (Basel)
August 2022
Article Synopsis
- Hsp70, a molecular chaperone, plays a role in cancer development and interacts with co-chaperone Bag3, which connects it to cancer-signaling pathways.
- Recent research revealed that Hsp70 also impacts macrophage movement and their ability to infiltrate tumors, but the underlying mechanisms remained unclear.
- Discoveries showed that Bag3 links Hsp70 to the transcription factor LITAF, which regulates inflammatory cytokines; this pathway influences macrophage motility and tumor infiltration through the chemokine CSF1.
