Publications by authors named "Lena A Lokker"
Article Synopsis
- * Current serological tests are not fully effective due to cross-reactive antibodies and lingering antibodies from past infections, highlighting the need for improved diagnostic methods.
- * Recent research has identified specific glycan antigens from the nematodes that stimulate distinct IgG responses, showing potential for more accurate diagnostics by analyzing IgG responses in infected individuals.
Mol Cell Proteomics
May 2022
Article Synopsis
- Millions are infected with filarial nematodes, causing diseases like lymphatic filariasis (LF), and while elimination efforts have decreased infections, better diagnostic tools are needed to monitor populations.
- Researchers explored the glycan structure of the filarial nematode Brugia malayi, identifying key glycan types through specialized techniques and demonstrating their potential as antigens for diagnostics.
- The study found that anti-glycan antibodies from hosts, particularly in infected humans and rhesus macaques, responded to B. malayi glycans, indicating these glycan markers could help in diagnosing and monitoring LF.
