Publications by authors named "Len Roth"
ACS Synth Biol
August 2024
Article Synopsis
- - Inflammatory bowel disease (IBD) is a chronic condition with limited treatments that can have negative side effects; researchers developed a targeted probiotic system (EcN) to potentially treat it.
- - This system uses a sensor to detect nitric oxide as a biomarker for inflammation and can secrete therapeutic nanobodies that work similarly to a common IBD drug, Adalimumab.
- - The study also created a mathematical model to help understand and optimize how these probiotics interact and function, enhancing the possibilities for future IBD therapies through synthetic biology.
