Publications by authors named "Lemei Chen"
Article Synopsis
- Long non-coding RNAs (LncRNAs), particularly MALAT1, are implicated in the regulation of diseases associated with vascular remodeling, especially in hypertension.
- The study found MALAT1 is upregulated in hypertensive aortic smooth muscle and its knockdown reduces VSMC proliferation and migration, which are influenced by Ang II.
- The research highlights a regulatory axis involving MALAT1, miR-145-5p, and hexokinase 2 (HK2), suggesting that this interaction is key in vascular smooth muscle cell behavior related to hypertension.
Alcohol use disorders (AUD) is characterized by persistent or intermittent alcohol cravings and compulsive drinking. The functional changes in the central nervous system (CNS) after alcohol consumption are alcohol-associated cognitive impairment and mood disorders, which are major health issues reported in AUDs. Studies have shown that transferring the intestinal microbiota from AUDs patients to germ-free animals causes learning and memory dysfunction, depression and anxiety-like behavior, indicating the vital role of intestinal microbiota in development of neuropsychiatric disorders in AUD.
View Article and Find Full Text PDFBackground: Esophageal carcinoma (EC) is one of the worst malignant digestive neoplasms with a strong tendency of invasion and metastasis. Despite the improvement of diagnostic and therapeutic methods in the past decades, the prognosis of EC remains unsatisfactory. Xiaoaiping injection (XAPI), a famous traditional Chinese herbal medicine, has been widely applied as a promising adjunctive drug for EC.
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