Normative database of donor keratographic readings in an eye-bank setting.

Purpose: To generate a normative donor topographic database from rasterstereography images of whole globes acquired in an eye-bank setting with minimal manipulation or handling.

Setting: Eye-bank laboratory.

Methods: In a retrospective study, rasterstereography topographic images that had been prospectively collected in duplicate of donor eyes received by the Central Ohio Lions Eye Bank between 1997 and 1999 were analyzed.

Creutzfeldt-Jakob disease in recipients of corneal transplants.

Purpose: Creutzfeldt-Jakob disease (CJD) transmission has been documented to occur from the use of corneal grafts. We report 4 cases of CJD with a history of corneal transplantation and assess the frequency of coincidental CJD among corneal transplant recipients.

Methods: Medical records and eye bank documents were reviewed.

CLMI: the cone location and magnitude index.

Purpose: To develop an index for the detection of keratoconic patterns in corneal topography maps from multiple devices.

Methods: For development, an existing Keratron (EyeQuip) topographic dataset, consisting of 78 scans from the right eyes of 78 healthy subjects and 25 scans from the right eyes of 25 subjects with clinically diagnosed keratoconus, was retrospectively analyzed. The Cone Location and Magnitude Index (CLMI) was calculated on the available axial and tangential curvature data.

Simulation of machine-specific topographic indices for use across platforms.

Purpose: The objective of this project is to simulate the current published topographic indices used for the detection and evaluation of keratoconus to allow their application to maps acquired from multiple topographic machines.

Methods: A retrospective analysis was performed on 21 eyes of 14 previously diagnosed keratoconus patients from a single practice using a Tomey TMS-1, an Alcon EyeMap, and a Keratron Topographer. Maps that could not be processed or that contained processing errors were excluded from analysis.

A prospective randomized clinical trial of laser in situ keratomileusis with two different lasers.

Purpose: To compare optical quality, visual function, corneal shape, ocular wavefront aberrations, and patient-reported symptoms and satisfaction after laser in situ keratomileusis (LASIK) with two different excimer lasers.

Design: Prospective randomized clinical trial.

Methods: In an institutional practice setting, 60 eyes of 30 patients with low to moderate myopia were randomized to receive LASIK in one eye with the Technolas 217A; the other eye was treated with the VISX S3.

Use of contact lenses for management of keratoconus.

This article describes use of contact lenses to manage patients with keratoconus. Fitting concepts, prefit evaluations, types of lenses, initial lens selection, and potential problems and solutions are discussed.

Omafilcon A (Proclear) soft contact lenses in a dry eye population.

Purpose: We conducted a 3-month, randomized, comparative cross-over study to evaluate the clinical performance of lenses manufactured from omafilcon A on subjects with signs and symptoms of dry eye. The subjects' own daily wear soft lenses were used as controls.

Methods: Seventy-six subjects with objective evidence of dry eye, as defined in the NEI/Industry Workshop Report 1995, were fit with either the omafilcon A lenses (Proclear) or new control lenses.

A comparison of the TMS-1 and the corneal analysis system for the evaluation of abnormal corneas.

We used two computerized corneal topography instruments (EyeSys Laboratories' Corneal Analysis System and the Topographic Modeling System (TMS-1) from Computed Anatomy, Inc.] to evaluate 18 eyes (ten patients) with abnormal corneas. The diagnoses included keratoconus, corneal scars, and residual postoperative astigmatism following refractive surgery.

Corneal microsporidioses: characterization and identification.

Two ocular infectious disorders attributed to Microsporidia have been observed. They differ in that one infection involves the corneal stroma leading to corneal ulceration and suppurative keratitis whereas the other infection involves the conjunctival and corneal epithelium. The corneal stromal infection is caused by a binucleated oval spore that is Nosema-like in character.

Management of keratoconus: comparative visual assessments.

We compared the visual performance of keratoconus patients whose vision had been corrected with one of the following: RGP lenses alone, penetrating keratoplasty, or epikeratoplasty. Despite similar Snellen visual acuities with optimal correction, significant differences in visual performance were found in the three groups. Visual performance was assessed by measuring contrast thresholds for electronically-generated sinusoidal gratings and by measuring contrast thresholds in the presence of a glare source.

Factitious bilateral crystalline keratopathy.

We report a case of bilateral factitious crystalline keratopathy in an 18-year-old man. Initial slit-lamp examination revealed corneal ulcers characterized by stromal infiltrates with intrastromal blue refractile crystals O.D.

Clinical management of keratoconus. A multicenter analysis.

The clinical management of 746 eyes in 417 patients referred for keratoconus from January 1984 through January 1988 was retrospectively analyzed. In 357 patients, 554 eyes (74%) did not require surgery and were managed with contact lenses or spectacles, 156 eyes (21%) in 137 patients either underwent penetrating keratoplasty (PK) (140 eyes) or surgery was recommended (16 eyes), and 36 eyes (4%) in 34 patients underwent epikeratoplasty. Comparing baseline and final examination findings, the nonsurgical group showed a significant improvement in average best-corrected visual acuity from 20/30 to 20/25, the PK group from 20/70 to 20/25, and the epikeratoplasty group from 20/40 to 20/30.

The use of contact lenses after keratoconic epikeratoplasty.

Thirty-three epikeratoplasties were performed on 31 keratoconic contact lens intolerant patients. Thirty-two of these procedures were anatomically successful with clear lenticules and flattening of the postoperative keratometric measurements in all but one eye. One patient's lenticule developed a persistent epithelial defect that eventually required its removal at 42 days.

Early results of epikeratophakia.

One hundred and seven patients underwent epikeratophakia for either adult or pediatric aphakia, keratoconus or myopia at the Ohio State University. Minimum follow-up was 3 months. There were four graft removals.

Epikeratophakia for pediatric aphakia.

We used epikeratophakia for rehabilitation in 11 contact lens-intolerant aphakic children aged 9 months to 14 years. Minimum follow-up was five months; the longest was 12 months. There were no graft failures, and no patients were unavailable for follow-up.