Publications by authors named "Lellis Henrique Costa"
Article Synopsis
- Sleep disorders are prevalent in children with Down syndrome (DS), substantially affecting their behavior and cognitive abilities.
- A systematic review of 52 studies showed that obstructive sleep apnea (OSA) is the most common sleep issue associated with DS, alongside potential cognitive dysfunction.
- Key treatments for OSA include continuous positive airway pressure (CPAP), surgical options, and lifestyle changes, with advanced imaging techniques aiding in planning surgeries.
Eugenia piauhiensis Vellaff. essential oil and γ-elemene its major constituent exhibit antileishmanial activity, promoting cell membrane damage and in vitro immunomodulation.
Thaís Amanda de Lima Nunes Lellis Henrique Costa Julyanne Maria Saraiva De Sousa Vanessa Maria Rodrigues De Souza Raiza Raianne Luz Rodrigues João Marcos Antônio Rodrigues Da Costa Leiz Maria Costa Véras Roseane Costa Diniz
Chem Biol Interact
April 2021
Leishmaniasis is considered as one of the most Neglected Tropical Diseases (NTDs) in the world, caused by protozoan parasites of the genus Leishmania. Treatment of leishmaniasis by chemotherapy remains a challenge because of limited efficacy, toxic side effects, and drug resistance. The search for new therapeutic agents from natural sources has been a constant for the treatment of diseases such as leishmaniasis.
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- * The study investigates the effects of methyl gallate (MG) on Leishmania (L.) amazonensis in vitro, testing its ability to inhibit both the promastigote and amastigote forms of the parasite while assessing its safety in macrophage cells.
- * Results show that MG is highly effective against the parasites with lower cytotoxicity compared to standard drugs, and it works by enhancing immune responses and cellular activities in macrophages, suggesting it could be an innovative treatment option for leishmaniasis.