Publications by authors named "Lele Qiu"

Article Synopsis
  • Epigenetic regulation is crucial for controlling cellular processes like growth and cell death, and small molecule modulators can fine-tune gene expression in these processes.
  • The study found that the dual-HDAC/LSD1 inhibitor I-4 significantly boosted monoclonal antibody production in CHO cells, leading to nearly double the antibody titer despite causing cell cycle arrest.
  • Results indicate that I-4 enhances protein expression by increasing histone acetylation and downregulating the HDAC5 gene, demonstrating a new approach to improve recombinant protein yields.
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The diffusion of iodine species and lead leakage during device degradation represent the main obstacles restricting the commercial application of perovskite solar cells (PSCs). Cobalt loaded ultrathin carbon nanosheets (Co(III)-CNS) derived from biomass are prepared as ion buffer material to construct robust hole transport layers (HTLs). The carbon nanosheets containing trivalent cobalt ions can facilitate the oxidation of the hole transport material while preserving the structural integrity and electrical properties of HTLs under thermal stress, thereby ensuring efficient carrier transport.

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  • CHO cells can be genetically engineered to boost their ability to produce therapeutic proteins, with recent focus on cell cycle and autophagy regulation to improve yields.
  • The study explored the small-molecule compound apilimod, which positively impacts recombinant protein expression by blocking the cell cycle at the G0/G1 phase.
  • Apilimod treatment altered the expression of key cell cycle regulators and reduced lysosome biogenesis and autophagy, indicating its potential as an enhancer for protein production in CHO cells.
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  • - Spiro-OMeTAD is the main hole transport material used in high-performance perovskite solar cells, but its low conductivity and poor interface properties limit efficiency and stability.
  • - To enhance performance, a new metal-organic framework called Zn-CBOB is introduced as a dopant for Spiro-OMeTAD, improving its conductivity and stabilizing the perovskite layer.
  • - The incorporation of Zn-CBOB results in a power conversion efficiency of 20.64% and increases the stability of the solar cells by protecting them from water damage.
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In this paper, we present a facile approach to enhance the efficiency and stability of perovskite solar cells (PSCs) by incorporating perovskite with microporous indium-based metal-organic framework [InO(OH)(HO)(btc)] (In-BTC) nanocrystals and forming heterojunction light-harvesting layer. The interconnected micropores and terminal oxygen sites of In-BTC allow the preferential crystallization of perovskite inside the regular cavities, endowing the derived films with improved morphology/crystallinity and reduced grain boundaries/defects. Consequently, the In-BTC-modified PSC yields enhanced fill factor of 0.

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Article Synopsis
  • - Recent advances in perovskite solar cells (PSCs) using spiro-OMeTAD have surpassed 20% efficiency, but challenges like poorly designed dopants and unclear mechanisms hinder commercial use.
  • - Researchers developed two new metal organic complexes (Cu-2Cl and Cu-4Cl) to improve the electrical properties of spiro-OMeTAD, with Cu-2Cl proving to be more effective due to its copper ion coordination and less harmful byproducts.
  • - Cu-2Cl not only enhances hole transport and reduces charge recombination but also protects the solar cells from moisture, leading to a record efficiency of 20.97% and maintaining 84% efficiency after 720 hours in ambient conditions
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The controllable oxidation of spiro-OMeTAD and improving the stability of hole-transport materials (HTMs) layer are crucial for good performance and stability of perovskite solar cells (PSCs). Herein, we report an efficient hybrid polyoxometalate@metal-organic framework (POM@MOF) material, [Cu (BTC) (H O) ] [H PMo O ] or POM@Cu-BTC, for the oxidation of spiro-OMeTAD with Li-TFSI and TBP. When POM@Cu-BTC is introduced to the HTM layer as a dopant, the PSCs achieve a superior fill factor of 0.

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Spiro-OMeTAD is currently the most widely used hole transport material for the preparation of high-performance perovskite solar cells (PSCs), usually requiring the addition of additives to achieve the desired electronic conductivity. However, the quality of the film is degraded owing to the addition of additives. Holes and defects can be observed, and the dispersion of the additives are uneven inside.

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CHO cells are the preferred host for the production of complex pharmaceutical proteins in the biopharmaceutical industry, and genome engineering of CHO cells would benefit product yield and stability. Here, we demonstrated the efficacy of a Dnmt3a-deficient CHO cell line created by CRISPR/Cas9 genome editing technology through gene disruptions in Dnmt3a, which encode the proteins involved in DNA methyltransferases. The transgenes, which were driven by the 2 commonly used CMV and EF1α promoters, were evaluated for their expression level and stability.

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  • - Dunaliella salina, a salt-tolerant marine alga, serves as a crucial model for understanding how extremophiles survive and their practical uses.
  • - The study utilized 2D-DIGE and MALDI-TOF/TOF MS to analyze protein expression under different salt concentrations, identifying 141 protein spots with significant changes.
  • - Key proteins linked to stress responses, photosynthesis, respiration, and amino acid synthesis were identified, indicating their roles in managing salt stress and maintaining cellular functions.
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The aim of this study was to investigate the protective effects of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rabbits and to explore the underlying mechanisms in order to provide experimental evidence for the clinical application of XMJ. An intraperitoneal injection of vitamin D3, combined with a high-fat diet and sacculus injury, was utilized to establish the AS rabbit model. Following the oral administration of lovastatin, Zhibituo and different dosages of XMJ, respectively, blood was drawn from each rabbit for the detection of blood rheological indicators, such as serum lipids.

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