STAT3-Mediated Promoter-Enhancer Interaction Up-Regulates Inhibitor of DNA Binding 1 () to Promote Colon Cancer Progression.

Background: High expression of inhibitor of DNA binding 1 () correlates with poor prognosis in colorectal cancer (CRC). Aberrant enhancer activation in regulating transcription is limited.

Methods: Immunohistochemistry (IHC), quantitative RT-PCR (RT-qPCR) and Western blotting (WB) were used to determine the expression of .

Asymmetric Divergent Synthesis of -Kaurane-, -Atisane-, -Beyerane-, -Trachylobane-, and -Gibberellane-type Diterpenoids.

A unified strategy toward asymmetric divergent syntheses of nine C8-ethano-bridged diterpenoids (candol A, powerol, sicanadiol, -candol A, atisirene, -atisan-16α-ol, 4-decarboxy-4-methyl-GA, trachinol, and -beyerane) has been developed based on late-stage transformations of common synthons having -kaurane and -trachylobane cores. The expeditious assembly of crucial advanced -kaurane- and -trachylobane-type building blocks is strategically explored through a regioselective and diastereoselective Fe-mediated hydrogen atom transfer (HAT) 6--trig cyclization of the alkene/enone and 3--trig cyclization of the alkene/ketone, showing the multi-reactivity of densely functionalized polycyclic substrates with π and π systems in HAT-initiated reactions. Following the rapid construction of five major structural skeletons (-kaurane-, -atisane-, -beyerane-, -trachylobane-, and -gibberellane-type), nine C8-ethano-bridged diterpenoids could be accessed in the longest linear 8 to 11 steps starting from readily available chiral γ-cyclogeraniol and known chiral γ-substituted cyclohexenone , in which enantioselective total syntheses of candol A (, 8 steps), powerol (, 9 steps), sicanadiol (, 10 steps), -candol A (, 8 steps), -atisan-16α-ol (, 11 steps), and trachinol (, 10 steps) are achieved for the first time.

Palladium-Catalyzed Asymmetric (4 + 2) Annulation of γ-Methylidene-δ-valerolactones with Alkenes: Enantioselective Synthesis of Functionalized Chiral Cyclohexyl Spirooxindoles.

An unprecedented asymmetric catalytic (4 + 2) annulation reaction of aryl-substituted γ-methylidene-δ-valerolactones (GMDVs) with isatin-derived -quinone methides (-QMs) has been developed under the catalysis of palladium(0) and (,,)-(-)-Xyl-SKP, offering a new approach for the diastereo- and enantioselective synthesis of chiral cyclohexadienone-fused cyclohexyl spirooxindoles. Significantly, three highly congested contiguous tetrasubstituted carbon atoms embedded in bispirocyclic skeleton, of which two are vicinal quaternary stereogenic centers, are forged in an effective and selective manner (up to 99% yield, up to 95% ee, >20/1 dr). The current reaction represents the first exploration of enantioselective catalytic (4 + 2) annulation forming the six-membered carbocycles in the chemistry of both GMDVs and -QMs.

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone.

Background: Silicone oil, as a major component in conditioner, is beneficial in the moisture preservation and lubrication of hair. However, it is difficult for silicone oil to directly absorb on the hair surface because of its hydrophobicity. Stable nanoemulsions containing silicone oil may present as a potential solution to this problem.