Publications by authors named "Lekovic G"

Background And Objectives: Exposure of the root entry zone (REZ) of the trigeminal nerve (TN) for microvascular decompression is commonly obtained with a retrosigmoid approach, with or without endoscopic assistance. We hypothesized that adequate exposure of the TN REZ could be obtained through an endoscopic retrolabyrinthine (RL) approach. We aim to quantify exposure of the REZ of the TN using endoscopic RL approach, with and without drilling of the suprameatal tubercle of the internal auditory canal.

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  • The study aimed to assess the viability of a new minimally invasive technique called the endaural keyhole for accessing the middle cranial fossa.
  • Researchers reviewed patient charts and conducted cadaver dissections to test this approach.
  • Six patients who underwent procedures like CSF leak repairs and tumor removals showed no complications using this technique, indicating its promise for treating various conditions in that brain area, but further research is needed.
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  • Stereotactic radiosurgery (SRS) shows better local tumor control compared to resection followed by SRS for treating facial nerve schwannomas, with 98% of SRS patients having tumor control versus 83% in the resection group.
  • Most patients in both treatment groups experienced favorable outcomes, but resection had more surgical complications, affecting recovery rates.
  • Older age, larger tumors, and involvement of the internal auditory canal were linked to worse outcomes for SRS patients, while these factors did not similarly impact the resection group.
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Objective: The role of surgical management of arachnoid cyst (AC) of the cerebellopontine angle (CPA) is uncertain. This topic has remained controversial with varying contradictory recommendations in the literature, which is limited to mostly case reports. We aimed to provide a comprehensive summary and analysis of symptoms, operative techniques, outcomes, and recurrence of all available surgical cases of AC of the CPA to date.

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The treatment of skull base paragangliomas has moved towards the use of cranial nerve preservation strategies, using radiation therapy and subtotal resection in instances when aiming for gross total resection would be expected to cause increased morbidity compared to the natural history of the tumor itself. The goal of this study was to analyze the role of surgery in patients with skull base paragangliomas treated with CyberKnife stereotactic radiosurgery (SRS) for definitive tumor control. A retrospective review identified 22 patients (median age 65.

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(1) Background: Incomplete excision of vestibular schwannomas (VSs) is sometimes preferable for facial nerve preservation. On the other hand, subtotal resection may be associated with higher tumor recurrence. We evaluated the correlation between intra-operative assessment of residual tumor and early and follow-up imaging.

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Article Synopsis
  • Cranial and spinal CSF leaks function differently, with opposing fluid dynamics, indicating distinct causes for each type of leak.
  • A 66-year-old woman experienced tension pneumocephalus linked to a CSF leak, requiring cranial surgery; however, she later developed positional headaches and imaging showed complications like subdural hematomas.
  • It's crucial for doctors to be vigilant about signs of intracranial hypotension due to spinal leaks following surgical repairs for CSF leaks, especially in cases involving otogenic pneumocephalus.
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  • Intracranial solitary fibrous tumors (ISFTs) are rare tumors from the meninges, often misdiagnosed due to their similarities with other brain tumors, and display unpredictable clinical behaviors despite being previously considered benign.
  • A case report details the malignant transformation of an ISFT in a 60-year-old female after radiation therapy, showcasing a progression from a benign diagnosis to a malignant one after recurrence.
  • This study highlights the importance of understanding the complex behavior of ISFTs and suggests that their clinical trajectory can vary significantly, which poses challenges for diagnosis and treatment.
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Background: Rhinorrhea due to lateral skull base cerebrospinal fluid (CSF) leaks can be a challenge to manage. Multiple strategies exist for treating CSF leaks in this region including direct repair, posterior Eustachian tube packing, and CSF diversion. Endonasal closure of the Eustachian tube has been reported using cerclage and mucosal flaps.

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Objective: In the current era of modern neurosurgery, the treatment strategies have been shifted to "nerve-preservation approaches" for achieving a higher facial and hearing function preservation rate following facial nerve tumors. We have conducted this novel report on determining the outcome of patients with facial nerve schwannomas (FNS) treated with hypofractionated stereotactic radiosurgery (hfSRS).

Patients: Retrospective chart review of a prospectively maintained database search was conducted.

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Introduction: Segmental neurofibromatosis (SNF) is a rare subtype of neurofibromatosis (NF). The disease is characterized by features circumscribed to one or more body cutaneous and/or subcutaneous segments. This is a classic example of somatic mosaicism which occurs by postzygotic mut ation of the NF1 gene late in the course of embryonic development affecting localized neural crest lines in the fetus.

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Objective: Sigmoid sinus (SS) stenosis is a complication of translabyrinthine approach. Velocity changes in the SS measured by intra-operative doppler ultrasound may help in identifying patients at risk for sinus occlusion.

Patients: SS velocity was measured using doppler ultrasound prior to opening dura and again prior to placement of the abdominal fat graft.

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Objective: Cerebellopontine angle (CPA) meningiomas can affect hearing function and require expeditious treatment to prevent permanent hearing loss. The authors sought to determine the factors associated with functional hearing outcome in CPA meningioma patients treated with surgery and/or radiation therapy in the form of either stereotactic radiosurgery or stereotactic radiation therapy.

Methods: Consecutive patients with CPA meningiomas who had presented at our hospital from 2008 to 2018 were identified through retrospective chart review.

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Objective: To evaluate the safety of 3 Tesla (T) magnetic resonance imaging (MRI) in patients with auditory brainstem implants (ABI) with the magnet removed at implantation and report incidence of complications.

Study Design: Retrospective chart review.

Setting: Tertiary neurotology ambulatory practice.

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Objective: To investigate the utility of the so-called "second window" of indocyanine green (ICG) as a near-infrared fluorescent dye for intraoperative visualization.

Patients: Three patients who underwent surgical resection of vestibular schwannoma (two retrosigmoid and one middle fossa approach).

Interventions: Patients underwent intravenous infusion of ICG at a mean dose of 4.

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Objectives: The aim of this study was to evaluate the value of digital subtraction angiography (DSA) in the diagnostic evaluation of a highly selected patient population presenting with pulse-synchronous tinnitus (PST).

Methods: We retrospectively reviewed the charts of all patients referred for evaluation of possible vascular etiology of pulsatile tinnitus. Patients were evaluated with regards to presenting signs, comorbidities, non-invasive imaging results, angiographic findings and outcomes.

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 Data regarding the surgical advantages and anatomic constraints of a hearing-preserving endoscopic-assisted retrolabyrinthine approach to the IAC are scarce. This study aimed to define the minimum amount of retrosigmoid dural exposure necessary for endoscopic exposure of the IAC and the surgical freedom of motion afforded by this approach.  Presigmoid retrolabyrinthine approaches were performed on fresh cadaveric heads.

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Objective: The management of neurofibromatosis type 2 (NF2)-associated meningiomas is challenging. The role of Gamma Knife radiosurgery (GKRS) in the treatment of these tumors remains to be fully defined. In this study, the authors aimed to examine the role of GKRS in the treatment of NF2-associated meningiomas and to evaluate the outcomes and complications after treatment.

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Objective: The facial recess approach during translabyrinthine surgery has been used to expose the eustachian tube (ET) for packing. We sought to determine the effect of this technique on the development of postoperative nasopharyngeal cerebrospinal fluid (CSF) leaks.

Patients: Cohorts of patients with cerebellopontine angle schwannomas who underwent a facial recess approach or no facial recess approach were matched based on tumor size.

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Objective: To assess clinical symptoms, signs, and radiographic evolution of middle cerebellar peduncle (MCP) diffusion restriction (DR) abnormalities following vestibular schwannoma (VS) resection.

Study Design: Retrospective chart and imaging review.

Setting: Tertiary-referral neurotology and neurosurgery practice.

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 Endolymphatic sac tumors (ELSTs) are a frequent cause of hearing loss and other audiovestibular dysfunction in patients with von Hippel-Lindau disease (VHL). Unified screening recommendations for VHL patients have not been established. To develop consensus guidelines, the VHL Alliance formed an expert committee to define evidence-based clinical screening recommendations.

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 Meningiomas are the second most common tumors in neurofibromatosis type 2 (NF-2). Microsurgery is challenging in NF-2 patients presenting with skull base meningiomas due to the intrinsic risks and need for multiple interventions over time. We analyzed treatment outcomes and complications after primary Gamma Knife radiosurgery (GKRS) to delineate its role in the management of these tumors.

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Objective: The objective is to describe auditory brainstem implantation in a case of extensive cochlear otosclerosis.

Patient, Intervention, And Results: A case is presented of a 65-year-old male with bilateral cochlear otosclerosis and profound sensorineural hearing loss. Imaging studies showed distorted cochlear anatomy bilaterally and ossification of cochlear ducts.

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