Publications by authors named "Lekai Yang"
Article Synopsis
- The study investigates the role of hepatic-derived extracellular vesicles (P-hEVs) from pregnant mice in promoting mammary gland development, which is vital for lactation.
- It was found that P-hEVs enhance the proliferation and differentiation of mammary epithelial cells, crucial for lactation preparation.
- The underlying mechanism involves activation of specific signaling pathways, including PI3K/AKT and JAK2/STAT5/mTOR, that support mammary gland growth and milk protein synthesis.
Skeletal muscle-fat interaction is essential for maintaining organismal energy homeostasis and managing obesity by secreting cytokines and exosomes, but the role of the latter as a new mediator in inter-tissue communication remains unclear. Recently, we discovered that miR-146a-5p was mainly enriched in skeletal muscle-derived exosomes (SKM-Exos), 50-fold higher than in fat exosomes. Here, we investigated the role of skeletal muscle-derived exosomes regulating lipid metabolism in adipose tissue by delivering miR-146a-5p.
View Article and Find Full Text PDFThe liver as the central organ is responsible for lipogenesis, gluconeogenesis and one-carbon metabolism. Methyl donors (e.g.
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