Disability Benefit and Gambling Disorder: A Longitudinal Study Based on National Registry Data.

Rates of gambling disorder (GD) have been found to be higher among people receiving disability benefit, but few studies have investigated whether receiving disability benefit prospectively actually increases the risk of GD. The present study investigated whether those with a disability benefit had an increased risk of developing GD using a case-control design. The study sample was retrieved from the Norwegian Patient Registry (NPR, N = 5,131) and consisted of all adults in Norway (18 years and older) who had received a GD diagnosis (F63.

Policies on Pulmonary Screening and Management of Respiratory Conditions in Military Pilots.

Introduction: Military pilots are subjected to unique pulmonary demands, particularly in high performance jets. The hypobaric environment necessitates use of on-board oxygen, breathing masks, and regulators to increase oxygen pressure, affecting ventilation and breathing responses. Safety features like pilot flight equipment and strapping into an ejection seat further impact pilot pulmonary function.

The Norwegian Counties Public Health Survey (NCPHS): a design study.

Background: Effective public health initiatives should be founded on a comprehensive and robust understanding of health-related factors including societal and community contexts. The Norwegian Counties Public Health Survey (NCPHS) aims for insights into the adult population on topics relevant for planning public health practices at county and municipality levels.

Methods: The NCPHS includes a core questionnaire on public health-related topics and demographics, including indicators of socio-economy, with additional optional questions and scales varying across data collections.

Normobaric Hypoxia Symptom Recognition in Three Training Sessions.

Introduction: Hypoxia training is mandatory for military pilots, but variability in hypoxia symptoms challenges the training. In a previous study we showed that 64% of pilots recognized hypoxia faster in their second normobaric hypoxia session conducted 2.4 yr after the first.

Association Between Cumulative G-force Exposure and Cervical Spine Degenerative Changes.

Introduction: Fighter pilots work in a unique environment and are subject to high G-force loads under simultaneous head movements. Neck pain is reported to be a common health problem among fighter pilots leading to time lost flying and flight duty limitations. The present study aimed to find out if differences in early military flight career G-force exposure levels could increase the risk for degenerative changes in the cervical spine.

Unemployment as a risk factor for gambling disorder: A longitudinal study based on national registry data.

Background And Aims: Unemployment rates are elevated among individuals with disordered gambling, yet the directionality of the relationship remains unclear. The present study investigated paid and unpaid unemployment as risk factors for future gambling disorder (GD).

Methods: The study employed a case-control design, including all adult Norwegians receiving a GD diagnosis within specialist health services from January 2008 to December 2018 (n = 5,131).

Comparative effectiveness of bivalent BA.4-5 or BA.1 mRNA booster vaccines among immunocompromised individuals across three Nordic countries: A nationwide cohort study.

Objectives: To estimate the effectiveness and waning of the bivalent BA.4-5 or BA.1 mRNA booster vaccine against Covid-19-related hospitalization and death in immunocompromised individuals.

Cardiac autonomic responses in relation to cognitive workload during simulated military flight.

Understanding the operator's cognitive workload is crucial for efficiency and safety in human-machine systems. This study investigated how cognitive workload modulates cardiac autonomic regulation during a standardized military simulator flight. Military student pilots completed simulated flight tasks in a Hawk flight simulator.

Estimated number of lives directly saved by COVID-19 vaccination programmes in the WHO European Region from December, 2020, to March, 2023: a retrospective surveillance study.

Background: By March, 2023, 54 countries, areas, and territories (hereafter CAT) in the WHO European Region had reported more than 2·2 million COVID-19-related deaths to the WHO Regional Office for Europe. Here, we estimated how many lives were directly saved by vaccinating adults in the WHO European Region from December, 2020, to March, 2023.

Methods: In this retrospective surveillance study, we estimated the number of lives directly saved by age group, vaccine dose, and circulating variant-of-concern (VOC) period, regionally and nationally, using weekly data on COVID-19 mortality and infection, COVID-19 vaccination uptake, and SARS-CoV-2 virus characterisations by lineage downloaded from The European Surveillance System on June 11, 2023, as well as vaccine effectiveness data from the literature.

Association between problem gambling and personality traits: a longitudinal study among the general Norwegian population.

Objective: The present study investigates the longitudinal relationship between problematic gambling (PG) and the five factor model's personality traits using autoregressive cross-lagged models.

Methods: The data used in the current study was collected by a national survey in 2013 ( = 10,081) and a follow-up study ( = 5,848) in 2015. PG was measured using Canadian Problem Gambling Index (CPGI) while personality was assessed using Mini-International Personality Item Pool (MINI-IPIP).

Ethnicity as a risk factor for gambling disorder: a large-scale study linking data from the Norwegian patient registry with the Norwegian social insurance database.

Background: The study investigated ethnicity as a risk factor for gambling disorder (GD), controlling for demographics, citizenship, and years of residency in Norway.

Methods: The sample comprised 65,771 individuals from a national patient registry (n = 35,607, age range 18-88 years) and a national social insurance database in Norway (n = 30,164, age rage 18-98 years). The data covered the period from 2008 to 2018.

Decline in varicella cases contacting primary health care after introduction of varicella vaccination in Finland - A population-based register study.

A two-dose varicella vaccination programme at the age of 18 months and 6 years started in September 2017 in Finland with catch-up vaccinations, based on earlier modelling results, for children <12 years (born in 2006 or later) with no history of varicella. Nationwide population-based register data were used to assess the age-specific vaccination coverage and the annual incidence rates of varicella cases contacting public primary health care in 2014-2020. Age-specific incidence rates after (2022) and before (2014-2016) the implementation of the vaccination programme was compared by incidence rate ratios (IRR) with 95 % confidence interval.

Income and gambling disorder: A longitudinal matched case-control study with registry data from Norway.

Background: Untangling the association between gambling disorder (GD) and income is complex. Financial strain is often a consequence of GD. At the same time GD is more prevalent in the context of poverty, suggesting income may be a risk marker for GD.

Delayed Drowsiness After Normobaric Hypoxia Training in an F/A-18 Hornet Simulator.

In military aviation, due to high-altitude flight operations, hypoxia training is mandatory and nowadays is mainly done as normobaric hypoxia training in flight simulators. During the last decade, scientific data has been published about delayed recovery after normobaric hypoxia, known as a "hypoxia hangover." Sopite syndrome is a symptom complex that develops as a result of exposure to real or apparent motion, and it is characterized by yawning, excessive drowsiness, lassitude, lethargy, mild depression, and a reduced ability to focus on an assigned task.

Temporal order of diagnosis between gambling disorder and substance use disorders: Longitudinal results from the Norwegian Patient Registry.

Introduction: Previous research has established co-occurrence between substance use disorders (SUDs) and gambling disorder (GD). Less well understood is the temporal sequencing of onset between these disorders, and in particular whether SUD is a risk factor for GD. The present study examined the temporal order between registered diagnoses of SUD and GD, stratified by sex.

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease.

Prolyl oligopeptidase (PREP) is a widely distributed serine protease in the human body cleaving proline-containing peptides; however, recent studies suggest that its effects on pathogenic processes underlying neurodegeneration are derived from direct protein-protein interactions (PPIs) and not from its regulation of certain neuropeptide levels. We discovered novel nonpeptidic oxazole-based PREP inhibitors, which deviate from the known structure-activity relationship for PREP inhibitors. These new compounds are effective modulators of the PPIs of PREP, reducing α-synuclein (αSyn) dimerization and enhancing protein phosphatase 2A activity in a concentration-response manner, as well as reducing reactive oxygen species production.