Publications by authors named "Leilei Liu"

Background: Although substantial evidence supports the advantages of cold snare polypectomy (CSP) in terms of polypectomy efficacy and reduced postoperative adverse events, few studies have examined the cost differences between CSP and traditional endoscopic mucosal resection (EMR) for the treatment of intestinal polyps.

Aim: To compare the efficacy-cost of EMR and CSP in the treatment of intestinal polyps.

Methods: A total of 100 patients with intestinal polyps were included in the retrospective data of our hospital from April 2022 to May 2023.

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In this work, an anionic framework Co-MOF () was elaborately constructed, which underwent single-crystal-to-single-crystal (SC-SC) transformation to produce and after immersion in a CrCl or FeCl solution. Despite the similar crystal structure, the significantly enhanced proton conductivities of and far exceed that of at all humidity and temperature conditions. Even at 30 °C and 98% RH, the proton conductivity of and can reach up to high values of 1.

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Few studies have examined the associations between long-term exposure to ultrafine particles (UFP) and type 2 diabetes (T2DM). This study aimed to investigate the impact of long-term UFP exposure on diabetes prevalence and stages, as well as glycemic markers, using data from a large multi-center cohort collected from 2017 to 2021. The health outcomes assessed included diabetes prevalence and stages (normoglycemia, prediabetes, and diabetes), as well as glycemic markers, i.

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In this work, an effective spoof surface plasmon polariton (ESSPP)-SSPP transmission line (TL) is proposed, which can operate in dual bands. Unlike SSPP TL, our ESSPP-SSPP TL allows for relatively accurate parameter estimation, independent control over each cutoff frequency, and low insertion loss. We provided the dispersion relation and closed-form formulas for calculating each cutoff frequency and explained the mechanism behind the independent controllability of each cutoff frequency.

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Ethnopharmacological Relevance: Shenling Baizhu San (SLBZS) is a Traditional Chinese Medicine (TCM) formula composed of 10 medicinal herbs, historically used to strengthen the spleen, replenish qi, and alleviate fatigue-related symptoms. SLBZS originates from the 'Taiping Huimin Heji Ju Fang' of the Song Dynasty. Central fatigue (CF), a subtype of fatigue, is considered in TCM to be closely associated with spleen deficiency.

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Low temperatures in late spring pose a potential threat to the maintenance of grain yield and quality. Despite the importance of protein and starch in wheat quality, they are often overlooked in models addressing climate change effects. In this study, we conducted multiyear environment-controlled phytotron experiments and observed adverse effects resulting from low-temperature stress (LTS) on plant carbon and nitrogen dynamics, grain protein and starch formation, and sink capacity.

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Ground settlement prediction for highway subgrades is crucial in related engineering projects. When predicting the ground settlement, sparse sample data are often encountered in practice, which greatly affects the prediction accuracy. However, this has been seldom explored in previous studies.

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Cognitive impairment (CI) is a type of mental health disorder that mainly affects cognitive abilities, such as learning, memory, perception, and problem-solving. Currently, in clinical practice, the treatment of cognitive impairment mainly focuses on the application of cholinesterase inhibitors and NMDA receptor antagonists; however, there is no specific and effective drug yet. Procatechuic acid (PCA) possesses various functions, including antibacterial, antiasthmatic, and expectorant effects.

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Background: High temperature stress (HTS) has become a serious threat to rice grain quality and few studies have examined the effects of HTS across multiple stages on rice grain quality. In the present study, we conducted 2 years of HTS treatments under three temperature regimes (32/22 °C, 40/30 °C and 44/34 °C) and HTS durations of 2 days and 4 days at three critical stages: booting, flowering, and a combination of booting and flowering. We employed the heat degree days (HDD) metric, which accounts for both the level and duration of HTS, to quantify the relationships between grain quality traits and HTS.

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With the aim of expanding the potential application scope of mulberries, eleven pH-switchable deep eutectic solvents were screened for the ultrasonic-assisted extraction of mulberry polysaccharides, and a salt/salt aqueous two-phase system was constructed for the efficient separation of mulberry polysaccharides by regulating the system pH. DES-9 (tetraethylammonium chloride: octanoic acid molar ratio = 1: 2) with a critical response pH value of approximately 6.1 was concluded to be the best extraction solvent for extracting mulberry polysaccharides.

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This study explores the integration of crop phenology models and machine learning approaches for predicting rice phenology across China, to gain a deeper understanding of rice phenology prediction. Multiple approaches were used to predict heading and maturity dates at 337 locations across the main rice growing regions of China from 1981 to 2020, including crop phenology model, machine learning and hybrid model that integrate both approaches. Furthermore, an interpretable machine learning (IML) using SHapley Additive exPlanation (SHAP) was employed to elucidate influence of climatic and varietal factors on uncertainty in crop phenology model predictions.

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The impact of metal exposure on cardiovascular diseases has become an increasingly concerning topic. To date, few studies have investigated the relationship between the copper-to-zinc ratio and CVD (Cardiovascular disease). This China multi-ethnic cohort study explored the association between the copper-to-zinc ratio and CVD in Chinese adults.

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Background: Spread through air spaces (STAS) is one of the multiple modes of lung cancer dissemination, yet its molecular and clinicopathological characterization remains poorly studied. This study aimed to investigate the effect of adhesion molecule expression levels on the incidence of STAS and postoperative recurrence in stage I lung cancer patients undergoing radical resection.

Methods: E-cadherin, P-cadherin, N-cadherin, focal adhesion kinase (FAK), epithelial cell adhesion molecule (EpCAM), neural cell adhesion molecule 1 (NCAM1), vascular cell adhesion molecule 1 (VCAM1), intercellular cell adhesion molecule-1 (ICAM-1) were analyzed retrospectively using immunohistochemistry in patients undergoing radical resection for stage I non-small cell lung cancer (NSCLC).

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Water reservoir sediments represent a distinct habitat that harbors diverse microbial resources crucial for nitrogen cycling processes. The discovery of resuscitation promoting factor (Rpf) has been recognized as a crucial development in understanding the potential of microbial populations. However, our understanding of the relationship between microorganisms containing -like genes and nitrogen-cycling functional populations remains limited.

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The efficient and complete extraction of uranium from aqueous solutions is crucial for safeguarding human health from potential radiotoxicity and chemotoxicity. Herein, an ultrathin 2D metal-organic framework (MOF) nanosheet with cavity structures was elaborately constructed, based on a calix[4]arene ligand. The large molecular skeleton and cup-shaped feature of the calix[4]arene enabled the as-prepared MOFs with large layer separations, which can be readily delaminated into ultrathin single-layer (∼1.

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The blood-brain Barrier (BBB), combined with immune clearance, contributes to the low efficacy of drug delivery and suboptimal treatment outcomes in glioma. Here, we propose a novel approach that combines the self-assembly of mouse bone marrow-derived macrophage membrane with a targeted positive charge polymer (An-PEI), along with low-frequency ultrasound (LFU) irradiation, to achieve efficient and safe therapy for glioma. Our findings demonstrate the efficacy of a charge-induced self-assembly strategy, resulting in a stable co-delivery nanosystem with a high drug loading efficiency of 44.

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Two crystalline large-sized porous organic cages (POCs) based on conical calix[4]arene (C4A) were designed and synthesized. The four-jaw C4A unit tends to follow the face-directed self-assembly law with the planar triangular building blocks such as tris(4-aminophenyl)amine (TAPA) or 1,3,5-tris(4-aminophenyl)benzene (TAPB) to generate a predictable cage with a stoichiometry of [6+8]. The formation of the large cages is confirmed through their relative molecular mass measured using MALDI-TOF/TOF spectra.

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Insect resistance evolution poses a significant threat to the advantages of biopesticides and transgenic crops utilizing insecticidal Cry-toxins from Bacillus thuringiensis (Bt). However, there is limited research on the relationship between transcriptional regulation of specific toxin receptors in lepidopteran insects and their resistance to Bt toxins. Here, we report the positive regulatory role of the SfGATAe transcription factor on the expression of the ABCC2 gene in Spodoptera frugiperda.

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Article Synopsis
  • Rice production is at risk due to climate change, particularly from heat stress (HS), which affects the remobilization of nonstructural carbohydrates (NSCs) in rice plants.
  • A study on two rice cultivars exposed to varying temperatures showed that while stem NSC concentrations increased, panicle NSC concentrations and their translocation efficiency decreased during heat stress.
  • The findings indicated that the flowering stage is the most vulnerable to HS impacts, with potential implications for developing heat-tolerant rice varieties by understanding NSC dynamics during stressful conditions.
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The effects of long-term exposure to fine particulate matter (PM) constituents on chronic kidney disease (CKD) are not fully known. This study sought to examine the association between long-term exposure to major PM constituents and CKD and look for potential constituents contributing substantially to CKD. This study included 81,137 adults from the 2018 to 2019 baseline survey of China Multi-Ethnic Cohort.

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Article Synopsis
  • Jianxin (JX) granules are a traditional Chinese medicine used to treat heart failure (HF), and this study investigates their treatment mechanism using network pharmacology and in-vivo experiments.
  • The research identified 122 active components, 896 drug targets, and 151 key targets related to HF, revealing important pathways and core hub genes such as IL-6 and VEGFA.
  • In-vivo experiments confirmed that JX granules enhance cardiac function and reduce heart tissue damage by influencing specific biomarkers and pathways involved in HF.
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Objective: To investigate the expression of C6orf15 protein in gastric endoscopic biopsy specimens and its usage as an ancillary diagnostic biomarker in determining the grade of gastric dysplasia.

Methods: We selected 102 patients with gastric endoscopic biopsy specimens from Jinling Hospital. These were divided into four groups: 22 cases of gastric mucosal benign lesions, 28 with low-grade dysplasia (LGD, intestinal-type: 21 cases,foveolar-type: 7cases), 28 with high-grade dysplasia (HGD, intestinal-type: 20 cases,foveolar-type: 8 cases), and 24 cases of gastric adenocarcinoma.

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Long noncoding RNAs (lncRNAs), as emerging regulators of a wide variety of biological processes via diverse mechanisms, have been demonstrated to be of increasing importance in biology. Genome-wide association studies of tumor samples have identified several lncRNAs as either oncogenes or tumor suppressors in various types of cancers. In recent years, the importance of lncRNAs, especially in endometrioid cancer (EEC), has become increasingly well understood.

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Background: Jiuwan decoction has been used to treat chronic eczema since the Qing Dynasty. According to clinical experience, Shizhenqing granules (SZQG), derived from the Jiuwan decoction, exert beneficial clinical effects on acute eczema and reduce recurrence. Therefore, we elucidated the underlying mechanisms of SZQG through network pharmacology, molecular docking, and experimental validation.

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