Causal Links Between Brain Functional Networks and Endometriosis: A Large-Scale Genetic-Driven Observational Study.

Introduction: Endometriosis is a chronic gynecological disorder that significantly impacts women of reproductive age. Recent evidence suggests a bidirectional link between endometriosis and brain functional networks, though the causal mechanisms remain unclear. This study aims to explore these relationships using Mendelian Randomization (MR) analysis.

Establishing and Validating an Innovative Focal Adhesion-Linked Gene Signature for Enhanced Prognostic Assessment in Endometrial Cancer.

Studies have highlighted the significant role of focal adhesion signaling in cancer. Nevertheless, its specific involvement in the pathogenesis of endometrial cancer and its clinical significance remains uncertain. We analyzed TCGA-UCEC and GSE119041 datasets with corresponding clinical data to investigate focal adhesion-related gene expression and their clinical significance.

Synthesis of Bimetallic Palladium/Zinc Oxide Nanocomposites Using Crocus sativus and Its Anticancer Activity via the Induction of Apoptosis in Cervical Cancer.

Palladium (Pd) and zinc oxide (ZnO) (Pd/ZnO NPs) bimettalic nanocomposites still lag much too far behind other nanoparticles investigated for various biological uses in the area of cancer treatments. Chemically created nanoparticles agglomerate under physiological conditions, impeding their use in biomedical applications. In this study, a straightforward and environmentally friendly method for creating bimetallic nanoparticles (NPs) by combining palladium (Pd) and zinc oxide (ZnO) using Crocus sativus extract (CS-Pd/ZnO NCs) was reported; the bio-synthesize bimetallic palladium/zinc oxide nanocomposites and their antioxidant and anti-cancer properties were assessed.

Novel sulfate solid supported binary Ru-Ir oxides for superior electrocatalytic activity towards OER and CER.

Electrolysis for producing hydrogen powered by renewable electricity can be dramatically expanded by adapting different electrolytes (brine, seawater or pure water), which means the anode materials must stand up to complex electrolyte conditions. Here, a novel catalyst/support hybrid of binary RuIrO supported by barium strontium sulfate (BaSrSO) was synthesized (RuIrO/BSS) by exchanging the anion ligands of support. The as-synthesized RuIrO/BSS exhibits compelling oxygen evolution (OER) and chlorine evolution (CER) performances, which affords to 10 mA cm with only overpotential of 244 mV and 38 mV, respectively.

Defective blue titanium oxide induces high valence of NiFe-(oxy)hydroxides over heterogeneous interfaces towards high OER catalytic activity.

Nickel-iron (oxy)hydroxides (NiFeOH) have been validated to speed up sluggish kinetics of the oxygen evolution reaction (OER) but still lack satisfactory substrates to support them. Here, non-stoichiometric blue titanium oxide (B-TiO) was directly derived from Ti metal by alkaline anodization and used as a substrate for electrodeposition of amorphous NiFeOH (NiFe/B-TiO). The performed X-ray absorption spectroscopy (XAS) and density functional theory (DFT) calculations evidenced that there is a charge transfer between B-TiO and NiFeOH, which gives rise to an elevated valence at the Ni sites (average oxidation state ∼ 2.

Gender-specific associations between abdominal adipose mass and bone mineral density in the middle-aged US population.

Objectives: The relationship between abdominal adipose tissue and osteoporosis is poorly understood. The purpose of this study was to examine the associations of abdominal adipose tissue with bone mineral density (BMD) among a nationally representative sample of US middle-aged adults.

Material And Methods: This study included 1498 participants from the National Health and Nutrition Examination Survey 2013-2014 and 2017-2018.

Ultra-stable cryogenic sapphire cavity laser with an instability reaching 2 × 10 based on a low vibration level cryostat.

Cryogenic ultra-stable lasers have extremely low thermal noise limits and frequency drifts, but they are more seriously affected by vibration noise from cryostats. Main material candidates for cryogenic ultra-stable cavities include silicon and sapphire. Although sapphire has many excellent properties at low temperature, the development of sapphire-based cavities is less advanced than that of silicon-based.

Intrinsic relationship between viscosity, viscosity index, and molecular structure of isoalkanes.

Context: Viscosity and viscosity index are the crucial properties of lubricant base stocks. Molecular dynamics simulation and quantum calculation were used to simulate the five isomers of CH to study the intrinsic relationship between viscosity, viscosity index, and the molecular structure of isoalkanes. The results showed that the intermolecular interaction energy and the volume of rigid-like groups were the intrinsic factors that affected the viscosity and which could describe the viscosity quantitatively.

Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial.

Background: The effect of anesthesia regimens on postoperative delirium after on-pump cardiac valve surgery is yet undetermined. This study aimed to evaluate the effect of volatile anesthesia compared with propofol-based total intravenous anesthesia (TIVA) on the occurrence of delirium after on-pump cardiac valve surgery.

Methods: This randomized clinical trial was conducted at a university academic hospital in China, from February 2019 to January 2021.

Effect of Volatile Anesthesia Versus Total Intravenous Anesthesia on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial.

Objectives: The purpose of this study was to evaluate the effect of volatile anesthesia and propofol-based total intravenous anesthesia (TIVA) on postoperative pulmonary complications (PPCs) among patients undergoing cardiac surgery.

Design: Parallel-group, randomized controlled trial.

Setting: Single-center tertiary care hospital.

Preparation and Characterization of Calcium-Incorporated Tratt and Its Efficacy on Bone Mineral Density in Rats.

The deficiency of traditional calcium preparation will gradually be replaced by the new type of calcium preparation. fruit () is popular for its rich nutrients and functional ingredients. The fermentation broth of , involving amino acids, flavonoids, triterpenes, polysaccharides, and other compounds, is favorable for calcium chelation.

Evaluation of the effects of Ipomoea staphylina on ovarian cancer cell line.

Ovarine cancer is a common woman malignancy in the world. Majority of the ovarian cancers are originated in the epithelial region which are lack of symptomps and this type of cancer is often get localized, when the tumour has spread outside the pelvis. Based on this context, the present study evaluated the effects of both aqueous and ethanolic extracts of Ipomoea staphylina leaves on ovarian cancer cell line.

UPLC-MS/MS-Based Rat Serum Metabolomics Reveals the Detoxification Mechanism of Psoraleae Fructus during Salt Processing.

Psoraleae Fructus (PF) is a botanical medicine widely used in Asian countries, of which salt products have higher safety and efficacy. However, the biological mechanism of the detoxification of salt-processing Psoraleae Fructus (SPF) has not yet been revealed. In this study, UPLC-MS/MS technology was used to explore the metabolic differences between SPF and PF in normal rats and reveal the mechanism of salt processing.

Vibration Property of a Cryogenic Optical Resonator within a Pulse-Tube Cryostat.

Cryogenic ultrastable laser cavities push laser stability to new levels due to their lower thermal noise limitation. Vibrational noise is one of the major obstacles to achieve a thermal-noise-limited cryogenic ultrastable laser system. Here, we carefully analyze the vibrational noise contribution to the laser frequency.

Hydroxyethyl starch 130/0.4 for volume replacement therapy in surgical patients: a systematic review and meta-analysis of randomized controlled trials.

Background: The safety of perioperative intravenous hydroxyethyl starch (HES) products, specifically HES 130/0.4, continues to be the source of much debate. The aim of this meta-analysis was to update the existing evidence and gain further insight into the clinical effects of HES 130/0.

polysaccharides inhibit ischemia/reperfusion-induced myocardial injury via the Nrf2 antioxidant pathway.

Oxidative stress is considered to be one of main pathophysiological mechanisms in myocardial ischemia/reperfusion (I/R) injury. polysaccharides (LBP), the main ingredient of , have potential antioxidant activity. We aimed to investigate the effects of LBP on myocardial I/R injury and explore the underlying mechanisms.

The Effect of Propofol Versus Volatile Anesthetics on Persistent Pain After Cardiac Surgery: A Randomized Controlled Trial.

Objectives: Sternal incisions can generate persistent and intense post-sternotomy pain. Propofol has been shown to improve postoperative analgesia, but the preventive effect on persistent pain after cardiac surgery is unknown. The hypothesis of the present study was that intraoperative propofol-based anesthesia compared with volatile anesthesia could reduce the risk of chronic pain after cardiac surgery.

Comparison of low and high inspiratory oxygen fraction added to lung-protective ventilation on postoperative pulmonary complications after abdominal surgery: A randomized controlled trial.

Study Objective: Intraoperative lung-protective ventilation strategy has been recommended to reduce postoperative pulmonary complications (PPCs). However, the role of inspiratory oxygen fraction (FiO) in this protection remains highly uncertain. We aimed to evaluate the effect of intraoperative low (30%) versus high (80%) FiO in the context of lung-protective ventilation strategy on PPCs in patients undergoing abdominal surgery.

CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling.

Background: Pancreatic cancer remains one of the most rapidly progressive and deadly malignancies worldwide. Current treatment regimens only result in small improvements in overall survival for patients with this cancer type. CPI-613 (Devimistat), a novel lipoate analog inhibiting mitochondrial metabolism, shows the new hope for pancreatic cancer treatment as an efficient and well-tolerated therapeutic option treated alone or in combination with chemotherapy.

Design and Synthesis of Arf1-Targeting γ-Dipeptides as Potential Agents against Head and Neck Squamous Cell Carcinoma.

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the leading causes of cancer-related deaths and calls for new druggable targets. We have previously highlighted the critical role of ADP-ribosylation factor-1 (Arf1) activation in HNSCC. In the present study, we address the question whether targeting Arf1 could be proposed as a valuable strategy against HNSCC.

PROtective Ventilation with a low versus high Inspiratory Oxygen fraction (PROVIO) and its effects on postoperative pulmonary complications: protocol for a randomized controlled trial.

Background: Postoperative pulmonary complications (PPCs) are the most common perioperative complications following surgical site infection (SSI). They prolong the hospital stay and increase health care costs. A lung-protective ventilation strategy is considered better practice in abdominal surgery to prevent PPCs.

Effect of structure regulation of hyper-branched polyester modified carbon nanotubes on toughening performance of epoxy/carbon nanotube nanocomposites.

In this paper, carboxylic multi-walled carbon nanotubes (MWCNTs-COOH) were modified by a series of hyperbranched polyesters (HBP) with different molecular structures (different branching degree) through surface grafting, and then the epoxy resin (EP)/carbon nanotube composites were prepared to explore the influences of structure regulation of HBP modified carbon nanotubes on the toughening performance of the composites. The results of Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA) of various HBP grafted carbon nanotubes confirmed that the HBP were successfully grafted onto MWCNTs-COOH an esterification reaction between the carboxyl groups of MWCNTs-COOH and the hydroxyl groups of HBP, meanwhile, the higher the branching degree of the HBP, the higher its grafting ratio onto carbon nanotubes. Furthermore, the outcome of dynamic thermal mechanical analysis (DMA) indicated that the addition of MWCNTs-COOH increased the storage modulus and glass transition temperature ( ) of the pure EP, and surface grafting of various HBP onto MWCNTs-COOH decreased the and peak height of mechanical loss of composites.

Influences of Hyperbranched Polyester Modification on the Crystallization Kinetics of Isotactic Polypropylene/Graphene Oxide Composites.

In this study, the hyperbranched polyester grafted graphene oxide (GO-H202) was synthesized, and the isotactic polypropylene/graphene oxide (iPP/GO) composites were prepared. Results of X-ray photoelectron spectra (XPS), Fourier transform infrared (FT-IR), and transmission electron microscopy (TEM) revealed the successful synthesis of GO-H202, while thermogravimetric analysis (TGA) indicated that the weight ratio of grafting was about 35 wt %. Differential scanning calorimetry (DSC) and polarized optical microscopy (POM) were carried out to investigate the role of GO and GO-H202 on the crystallization kinetics of the composites.

Nck-associated protein 1 associates with HSP90 to drive metastasis in human non-small-cell lung cancer.

Background: Metastatic lung cancer is a life-threatening condition that develops when cancer in another area of the body metastasizes, or spreads, to the lung. Despite advances in our understanding of primary lung oncogenesis, the biological basis driving the progression from primary to metastatic lung cancer remains poorly characterized.

Methods: Genetic knockdown of the particular genes in cancer cells were achieved by lentiviral-mediated interference.