Publications by authors named "Leilei Gou"
Background: Inflammation and breast cancer are closely associated. Considering that mast cells are essential component of inflammatory cells, its relationship with breast cancer arose rising attention.
Purpose: This study aims to elucidate the influence of mast cells on triple negative breast cancer (TNBC) and explore potential therapeutic interventions targeting mast cells.
Article Synopsis
- Eriocalyxin B (Eri B), derived from the Isodon eriocalyx plant, demonstrates anti-tumor and anti-angiogenic effects specifically against triple negative breast cancer (TNBC) cells.
- The study found that Eri B inhibits TNBC cell migration, adhesion to extracellular matrix, and decreases colonization potential in cancer stem cell-rich MDA-MB-231 cells.
- In various mouse models, Eri B showed significant anti-metastatic effects and also altered gut microbiome diversity, supporting its potential use as an anti-metastatic agent for breast cancer treatment.
Breast cancer is an inflammation-related cancer whose tumor microenvironment is largely infiltrated by inflammatory cells. These inflammatory cells including mast cells and macrophages have been elucidated to be vital participants in breast tumor proliferation, survival, invasion and migration. However, the functions of mast cells and macrophages in breast cancer are quite distinct based on recent data.
View Article and Find Full Text PDFChaetolactam A (), an unprecedented azaphilone derivative bearing a unique 9-oxa-7-azabicyclo[4.2.1]octan-8-onering system, together with two new compounds, 11--chaetomugilide B () and chaetomugilide D () was isolated from an endophytic fungus, sp.
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