Recent Focuses in the Syntheses and Applications of Magnetic Metal-Organic Frameworks.

In this article, we examine the recent uses of magnetic metal-organic frameworks (MMOFs). MMOFs can be used in various fields such as water purification, laboratory, food, environment, etc. Their materials can be composed of different metals and ligands, each of which has its own properties.

Greener Syntheses of Coumarin Derivatives Using Magnetic Nanocatalysts: Recent Advances.

Coumarins (2H-1-benzopyran-2-ones) are an important group of biological heterocyclic compounds present in various parts of many plant species, encompassing an array of biological and pharmaceutical activities. In view of the importance of coumarins in heterocyclic chemistry and biological sciences and recent advances in the design of magnetic nanocatalysts, we present herein recent developments pertaining to their synthesis exclusively using magnetic nanoparticles, which can be retrieved easily and thus conform to the tenets of greener synthesis. The preparation of various types of coumarins such as Pechmann-based coumarins, bis coumarins, pyranocoumarins, and coumarin derivatives bearing amine moiety, linked to nicotinonitriles, N-coumarin-2-furanone, and pyrrole-linked chromene derivatives using nanocatalysts with a FeO core are described.

Green Synthesis of Mono, Bis and Tris Aminobenzochromenes and Benzopyranochromenes using FeO@Sio@ Vanillin/Vitamin B1 Nanoparticles: A New, Mild, Simple and Effective Bronsted Acid Catalyst for the Synthesis of Chromenes.

Objective: Vanillin/Vitamin B1 (Thiamine) supported FeO@Sio nanoparticles (FeO @SP@VT) were synthesized and thoroughly analyzed, and were used for the green and efficient synthesis of chromenes using the multicomponent reaction of aldehyde, malononitrile and 4-hydroxy coumarin, as well as the multicomponent reaction of aldehyde, α-naphthol or β-naphthol and 4-hydroxy coumarin.

Methods: The reaction was performed under grinding conditions, and at the end of the reaction, the catalyst was separated in the presence of a strong magnet and can be recovered 10 times.

Results: The advantages of this method are high purity of products, short times, higher yield, easy separation and cheap raw materials.

Green synthesis of novel 5-amino-bispyrazole-4-carbonitriles using a recyclable FeO@SiO@vanillin@thioglycolic acid nano-catalyst.

Bis(thioglycolic acid)-vanillin (2,2'-(((4-hydroxy-3-methoxyphenyl)methylene)bis(sulfanediyl))diacetic acid)-functionalized silica-coated FeO magnetic nanoparticles (FeO@SiO@vanillin@thioglycolic acid MNPs) were synthesized and characterized by transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), thermogravimetric analysis/differential thermogravimetry (TGA-DTG), X-ray powder diffraction (XRD), X-ray spectroscopy (EDX), vibrating sample magnetometry (VSM), zeta potential measurements and Fourier transform infrared spectroscopy (FT-IR). The ensuing MNPs offer an environmentally friendly procedure for the synthesis of novel 5-amino-pyrazole-4-carbonitriles a three-component mechanochemical reaction of synthesized azo-linked aldehydes or synthesized pyrazolecarbaldehydes, malononitrile, and phenylhydrazine or -tolylhydrazine adhering to the green chemistry principles; products were generated expeditiously in high yields. The catalyst could be quickly recovered and reused for six cycles with almost consistent activity.

Green Synthesis of New Category of Pyrano[3,2-c]Chromene-Diones Catalyzed by Nanocomposite as Fe3O4@SiO2-Propyl Covalented Dapsone-Copper Complex.

Nanomagnetic dapsone-Cu supported on the silica-coated FeO (FeO@SiO-pr@dapsone-Cu) nanocomposite was synthesized and characterized by Fourier transform infrared (FT-IR), energy-dispersive X-ray (EDX), X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), transmission electron microscopy (TEM), zeta potential, vibrating sample magnetometer (VSM), and thermogravimetric analysis (TGA). This newly synthesized nanocomposite was chosen to act as a green, efficient, and recyclable Lewis acid for the multicomponent synthesis of new derivatives of pyrano[3,2-c]chromene-diones through the reaction of aromatic aldehydes, indandione, and 4-hydroxycoumarin in water. All of the synthesized compounds are new and are recognized by FT-IR, NMR, and elemental analysis; this avenue is new and has advantages such as short reaction times, high productivity, economical synthesis, and use of green solvent, HO, as a medium.

Synthesis of Fused Azo-linked Acridine Derivatives Using MCM-41/Ag2S-RHA Nanocomposite.

Introduction: In this study, the synthesis of azo-linked acridine by the reaction of dimedone and synthesized diazoaryl-(2-amino-5-(phenyl)methanone using Ag2S/RHA-MCM-41nanocomposite is reported.

Materials And Methods: The synthesized catalyst was characterized by FT-IR, XRD, and SEM. According to the obtained results, AgS/RHA-MCM-41 nanocomposite exhibited high activity in the synthesis of azo-acridine derivatives based on desirable yields and reaction time.

One-pot Synthesis of a New Category of 2-aryl-quinazolinones Using OImDSA as an Efficient Heterocyclic Medium.

Background: Dihydroquinazolinone derivatives are an important family of fused heterocyclic compounds which possess a wide range of biological, medicinal and pharmacological properties such as anti-tumor, anti-biotic, diuretic, analgesic, anti-hypertonic, anti-pyretic, antidepressant, anti-histamine and vasodilation activities.

Introduction: So far, some acid catalysts, e.g.

Acidic Ionic Liquid-catalyzed Synthesis of Pyrano[4,3-b]pyran-5(4H)-ones using 4,4,4-trifluoro-1-phenylbutane-1,3-dione as a Building Block.

Aims: synthesis of pyrano[c-2,3]chromens with Ionic Liquid catalyst with simple method.

Background: Synthesis of pyrano[c]coumarins has a special place in the structure due to two bioactive compounds in its structure and attracts a great deal of attention in this research work, it has been attempted to attach chromatically valuable skeletons to them and synthesize the pyrano [c] coumarines, which can potentially have high biological properties. For this purpose, electrophilic β-ketoester ringing in the presence of ionic liquid catalysts was used.

s-Proline Covalented Silicapropyl Modified Magnetic Nanoparticles: Synthesis, Characterization, Biological and Catalytic Activity for the Synthesis of thiazolidin-4- ones.

Background: Thiazolidinoneones are important pharmaceutical compounds because of their biological activities. Several methods for the synthesis of 4-thiazolidinones are widely reported in the literature. The main synthetic routes to synthesize 1,3-thiazolidin-4-ones involve three components reaction between amine, a carbonyl compound and thioglycolic acid.

Grinding Synthesis of Pyrazolyl-Bis Coumarinyl Methanes Using Potassium 2-Oxoimidazolidine-1,3-diide.

Aim And Objective: Potassium 2-oxoimidazolidine-1,3-diide (POImD) as a novel and reusable catalyst was used for the synthesis of pyrazolyl-bis coumarinyl methanes by a nucleophilic addition reaction of synthetized pyrazolecarbaldehyde and two equivalents of 4-hydroxycoumarin under grinding. The catalyst can be reused and recovered several times without loss of activity. This method provides several advantages such as eco-friendliness, simple work-up and shorter reaction time as well as excellent yields.

Urazolium diacetate as a new, efficient and reusable Brønsted acid ionic liquid for the synthesis of novel derivatives of thiazolidine-4-ones.

Urazolium diacetate catalyzed synthesis of new derivatives of 1,3-thiazolidine-4-ones (azo dispersive dyes family) multicomponent reaction of various aldehydes, thioglycolic acid and 4-aminoazobenzene under solvent-free reaction was reported. This avenue for the synthesis of new derivatives of thiazolidine-4-one has advantages as: short reaction times, high yields, green aspect of chemistry and environmental friendliness, easy workup, solvent-free conditions and convenient operation.

Synthesis and characterization of amino glucose-functionalized silica-coated NiFeO nanoparticles: a heterogeneous, new and magnetically separable catalyst for the solvent-free synthesis of pyrano[3,2-]chromen-5(4)-ones.

A novel, efficient and one-pot multi-component procedure for the synthesis of simple pyrano[3,2-]chromen-5(4)-ones or pyrazolyl pyrano[3,2-]chromen-5(4)-ones reaction of aryl aldehydes, acetophenones and 4-hydroxycoumarin promoted by amino glucose-functionalized silica-coated NiFeO nanoparticles under solvent-free conditions without using any other harmful organic reagents was reported. The structure of this nanoparticle was characterized by transmission electron microscopies, X-ray diffraction and Fourier transform infrared spectroscopies. The catalyst could easily be separated from the reaction mixture by using an external magnetic field and it was reusable.

Cross-Dehydrogenative Coupling Reactions Between P(O)-H and X-H (X = S, N, O, P) Bonds.

P(O)-X (X = S, N, O, P) bond-containing compounds have extensive application in medicinal chemistry, agrochemistry, and material chemistry. These useful organophosphorus compounds also have many applications in organic synthesis. In light of the importance of titled compounds, there is continuing interest in the development of synthetic methods for P(O)-X bonds construction.

Recent advances in sulfur-nitrogen bond formation cross-dehydrogenative coupling reactions.

This focus-review surveys literature methods for the construction of sulfur-nitrogen bonds through cross-dehydrogenative coupling reactions between thiols and N-H compounds with a particular emphasis on the mechanistic aspects of the reactions. The literature has been surveyed until the end of 2017.

Ultrasound Assisted 1,4-diazabicyclo[2.2.2] Octaniumdiacetate Multicomponent Synthesis of Benzodiazepines: A Novel, Highly Efficient and Green Protocol.

A simple and efficient method is presented for the synthesis of benzodiazepines through the multicomponent reaction of o-phenylenediamine, various aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of the acidic bis ionic liquid 1,4-diazabicyclo[2.2.2]octanium diacetate under ultrasound irradiation.

Citrus Juice: Green and Natural Catalyst for the Solvent-free Silica Supported Synthesis of β-Enaminones Using Grindstone Technique.

Aim And Objective: Citrus Juice as an efficient, cost-effective and green catalyst employed for one-pot synthesis of various β-substituted enaminones through the reaction of β- dicarbonyl compounds with different primary amines in a solvent-free conditions on silica gel as solid surface using grindstone technique in high yields and short reaction times. The presented procedure is operationally simple, practical and green.

Material And Methods: The wide application of this procedure is demonstrated by the use of various substituted amines to react with β-dicarbonyl compounds.

Fe3O4@SiO2@KIT-6 as an Efficient and Reusable Catalyst for the Synthesis of Novel Derivatives of 3,3'-((Aryl-1-phenyl-1H-pyrazol-4- yl)methylene)bis (1H-indole).

Aim And Objective: Korea advanced institute of science and technology cubic ordered mesoporous silica (KIT-6 mesoporous) silica coated magnetite nanoparticles, is an effective, ecobenign and recyclable catalyst for the electrophilic substitution reactions of indoles with various synthetized aldehydes to afford the corresponding novel diindolylmethanes in high yields and short reaction times. The catalyst can be recovered and reused without loss of activity. The work-up of the reaction consists of a simple separation, followed by concentration of the crude product and purification.

1,4-Diazaniumbicyclo[2.2.2]octane Diacetate: As an Effective, New and Reusable Media for the Synthesis of 14-Aryl-14H-dibenzo[a,j]xanthenes.

A general synthetic route to dibenzoxanthenes has been developed using 1,4-diazaniumbicyclo[2.2.2]octane diacetate as a new bis ionic liquid under thermal and solvent free condition.

An efficient and green synthesis of novel benzoxazole under ultrasound irradiation.

Ultrasound as green process and an alternative energy source was investigated for the environmentally benign synthesis of novel benzoxazoles from different azo-linked salicylic acid derivatives and 2-amino-4-chlorophenol in short reaction time and high yield. These benzoxazole compounds have been characterized by elemental analysis, FT-IR, (1)H NMR and (13)C NMR spectroscopy.