Publications by authors named "Leila Zaki"

Anaplasma phagocytophilum is an emerging tick-borne zoonotic bacterium, which is considered a significant risk to the health and industry of cattle in tropical and sub-tropical regions worldwide. This research focuses on examining the worldwide occurrence of A. phagocytophilum in cattle.

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Microsporidia are intracellular parasites with significant impact on both animal and human health. The prevalence of microsporidia infections in rabbits, including the genera Enterocytozoon and Encephalitozoon, underscores the importance of understanding their epidemiology for effective control strategies. This systematic review and meta-analysis estimated the global prevalence of microsporidia infection in rabbits using five databases (Scopus, PubMed, Embase, Web of Science, and Google Scholar) to retrieve articles published between 03 December 2003 and 26 March 2023.

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Among the potential animal reservoirs of the zoonotic parasite , birds have received relatively little attention. This systematic review and meta-analysis aimed to assess the global status and to provide an overview of the epidemiology of infection in birds. The standard protocol of preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed.

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Background: Canine babesiosis is a clinically significant tick-transmitted disease caused by several species of the intraerythrocytic protozoan parasite Babesia, which result in a wide range of clinical manifestations, from mild, transient infection to serious disease and even death.

Objectives: The current study aimed to estimate the global prevalence and associated risk factors of Babesia in dogs.

Methods: Multiple databases (PubMed, Scopus, ProQuest, Web of Science and Google Scholar) were searched for relevant literature published from January 2000 up to December 2022.

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Background: We aimed to assess the in vitro effects of the green synthesized silver nanoparticles via thyme against infection.

Methods: We have prepared silver nanoparticles (TSNPs) by adding extract to the silver nitrate aqueous solution (0.2 mM), and evaluated their antileishmanial activity.

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Background: Spirometra infection is aneglected food- and waterborne disease with worldwide distribution.

Objectives: The present study aims to estimate the global prevalence of Spirometra species in snakes, frogs, dogs and cats.

Methods: Multiple databases (PubMed, Scopus, ProQuest, Web of Science and Google Scholar) were searched for relevant literatures published up to March 2022.

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Purpose: Toxoplasmosis can induce various hormonal and behavioral alterations in humans and rodents. Previous studies revealed alterations of sex hormones; especially testosterone, in infected humans and rodents, but little is known about the effects of sex hormones on the propagation of T. gondii.

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Background: Microsporidia are spore-forming intracellular pathogens with worldwide prevalence, causing emerging infections in humans and animals. Enterocytozoon bieneusi is a zoonotic species of microsporidia and is responsible for more than 90% of cases of microsporidiosis in humans and animals. Pigs and wild boars are important animal reservoirs of microsporidia.

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Background: Transport-related injuries (TIs) are a substantial public health concern for all regions of the world. The present study quantified the burden of TIs and deaths in the Eastern Mediterranean region (EMR) in 2017 by sex and age.

Methods: TIs and deaths were estimated by age, sex, country, and year using Cause of Death Ensemble modelling (CODEm) and DisMod-MR 2.

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Introduction: Leishmaniasis is a major public health problem that causes by parasite of the genus Leishmania. The pentavalent antimonial compounds that used for treatment are not safe or effective enough. The aim of the present study was preparation and evaluation of the efficacy of green synthesized silver nanoparticles against Leishmania major (L.

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Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys will need to be conducted across all implementation units (IUs) for which endemicity status is currently unknown. Using boosted regression tree models with optimised hyperparameter selection, we estimated environmental suitability for onchocerciasis at the 5 × 5-km resolution across Africa.

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Article Synopsis
  • Imiquimod shows potential as a treatment for toxoplasmosis by reducing tachyzoite viability in both infected macrophages and BALB/c mice.
  • The study found that pre-treatment with imiquimod significantly lowered parasite load and improved survival rates compared to post-treatment.
  • Findings suggest that imiquimod could be a promising candidate for both preventing and treating toxoplasmosis, as it enhanced macrophage apoptosis and modulated immune responses.
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Article Synopsis
  • Common medicines for toxoplasmosis have limitations, prompting research into morphine's potential effects on treating the infection.
  • In experiments, morphine was tested on tachyzoites and infected macrophages, revealing that lower doses were more effective in reducing parasite loads and improving survival rates in mice when administered before infection.
  • The study concluded that morphine has a preventive and therapeutic role against toxoplasmosis, with pre-treatment showing greater effectiveness compared to post-treatment.
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Article Synopsis
  • Cancer and other noncommunicable diseases (NCDs) pose a significant threat to global development, with slow progress in addressing these issues highlighted by the recent UN meeting; key barriers include a lack of situational analyses and prioritization for effective action against NCDs.* -
  • The study aims to provide comprehensive data on cancer burden across 29 cancer types in 195 countries from 1990 to 2017, utilizing the Global Burden of Disease (GBD) methods to analyze cancer incidence, mortality, and disability metrics.* -
  • In 2017, there were 24.5 million new cancer cases globally, with significant variations based on socio-demographic factors; the majority of cancer-related disabilities stemmed
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Fascioliasis is a tropical zoonotic disease caused by the parasite. The adult parasite usually resides in the liver and biliary ducts; however, several cases of ectopic fascioliasis (EF) have been reported. This study is a highlight on EF according to the confirmed case reports.

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() is an obligate intracellular parasite with worldwide distribution. It is estimated that near one-third of the people around the globe are latently seropositive for the parasite. Since the current common drugs are incapable in the elimination of parasites within tissue cysts, the development of an effective vaccine has high priority for researchers to limit the infection.

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Toxoplasmosis is a cosmopolitan zoonotic disease, which infect several warm-blooded mammals. More than one-third of the human population are seropositive worldwide. Due to the high seroprevalence of infection worldwide, the resulting clinical, mental, and economical complications, as well as incapability of current drugs in the elimination of parasites within tissue cysts, the development of a vaccine against would be critical.

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