Publications by authors named "Leila Sarah Sellam"
The upregulation of checkpoint inhibitor PD-L1 expression has recently been associated with nasopharyngeal carcinoma (NPC) resistance to therapy. The mechanism of induction of PD-L1 has also been linked to enhanced aerobic glycolysis promoted by HIF1-α dysregulation and LDH-A activity in cancer. Here, we investigated the effect of the anti-tumoral compound Silibinin on HIF-1α/LDH-A mediated cancer cell metabolism and PD-L1 expression in NPC.
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- - Breast cancer is highly prevalent among women in Algeria, and the age at which they are diagnosed is significantly younger than in Western countries.
- - This study investigates the expression of specific miRNAs (such as miR-21 and miR-200c) in breast cancer tissue compared to normal adjacent tissue, finding several miRNAs to be upregulated in tumor samples.
- - The results suggest a potential for using miRNA profiling to discover biomarkers that could be specific to the Algerian population's breast cancer cases, highlighting the need for further research in this area.
Laryngeal squamous cell carcinoma (LSCC) is an aggressive malignancy which lacks early predictors of prognosis. Here, we hypothesized that expression and prognostic characterization of the critical mediators of epithelial to mesenchymal transition (EMT) may provide key information in this regard. Linear regression and multiple correspondence analyses were performed on immunohistochemical data obtained from 20 invasive tumors.
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