Publications by authors named "Leila Nejatbakhsh Samimi"

The tumor microenvironment (TME), as an immunosuppressive milieu, has a critical role in tumor progression and increases resistance to the conventional treatments. Among the abundant immunosuppressive cells in the TME, tumor-associated macrophages (TAMs) could be a promising target for reprogramming and potentiating the local anti-tumor response. On the other hand, hypoxia is a major barrier in treating solid tumors, which aggravates the situation and alleviates the anti-tumor immune responses.

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Ankylosing spondylitis (AS) is a systemic inflammatory disorder of joints and entheses. Recent studies have reported an increased prevalence of dementia in AS patients. However, data for exploring the association between dementia and AS remain uncertain.

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Objective: Natural killer (NK) cells are part of the innate immune system which not only provides a primary response to pathogenic conditions but can also play an important regulatory role in immune responses. Furthermore, these cells can influence immune responses by affecting other involved cells. Human NK cells can be classified as CD56 and CD56; the former demonstrates mostly cytotoxic effects, while the latter comprises mostly tolerant or regulatory NK cells.

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Article Synopsis
  • Ankylosing spondylitis (AS) is an autoimmune disease with unclear mechanisms, prompting this study to identify candidate genes associated with it.
  • Researchers analyzed publicly available datasets and discovered that the ribosome pathway was significantly up-regulated in AS patients, with specific ribosomal components being overexpressed.
  • The study confirmed the dysregulation of certain genes (rRNA5.8S, rRNA18S pseudogenes, and RPL17) in AS patients, suggesting that ribosome biogenesis may play a role in the disease's pathology.
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Objectives: Ankylosing spondylitis (AS) is a rheumatic disorder that is mostly determined by genetic and environmental factors. Given the known importance of macrophage in AS pathogenesis, we investigated the transcriptional profile of macrophage cells in the disease.

Methods And Results: Two approaches of differential expression and subsequently, weighted gene co-expression network analysis was utilized to analyze a publicly available microarray dataset of macrophages.

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There is a significant fluctuation in clinical symptoms of asthmatic females during their life course, suggesting that the reproductive status and the level of sex hormones may affect the development of asthma and its exacerbation. In this study, we aimed to assess the biological effects of 17β-estradiol (E2) and progesterone (P4), alone or in combination form, on the transcription factors and production of cytokines in peripheral blood mononuclear cells (PBMCs). PBMCs of the mild-to-moderate asthmatic patients and healthy controls (HCs) were treated with equivalent serum levels of E2 or P4 maintained during hormone replacement therapy (HRT).

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