The role of the PPARG (Pro12Ala) common genetic variant on type 2 diabetes mellitus risk.

Background: Type 2 diabetes (T2DM) prevalence has been rapidly increasing in the last decades. T2DM pathogenesis is related to insulin resistance and beta-cell dysfunction. is concerned about T2DM risk through the involvement in adipocyte differentiation and energy homeostasis.

PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis.

Type 2 diabetes mellitus (T2DM) is a complex disease caused by the interaction between genetic and environmental factors. A growing number of evidence suggests that the peroxisome proliferator-activated receptor gamma (PPARG) gene plays a major role in T2DM development. Meta-analysis of genetic association studies is an efficient tool to gain a better understanding of multifactorial diseases and potentially to provide valuable insights into gene-disease interactions.

High-Temperature Performance Evaluation of Asphaltenes-Modified Asphalt Binders.

Asphalt binder comprises four main fractions-asphaltenes (A), saturates (S), aromatics (A), and resins (R)-referred to as "SARA". Asphaltenes plays an important role in determining the linear viscoelastic behavior of asphalt binders. In this research, asphaltenes are added as a distinct modifier to improve the performance properties of asphalt binder.