Publications by authors named "Leila Ghasempour"
This article reports one-pot synthesis of ten novel spirooxindoles using 5-methyl-2-thiohydantoin, isatin derivatives, and malononitrile in good to high yields (65-90 %). The structures of the synthesized compounds were deduced by H-NMR, C NMR, FT-IR, and Mass spectral data. The antibacterial activity of the compounds was evaluated against two Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) based on the Kirby-Bauer method.
View Article and Find Full Text PDFIn this study, the synthesis of new spiropyrazoles, pyrazole and hydantoin heterocycles is reported by three component reactions of parabanic acids, hydrazine derivatives, and phenacyl bromides in the presence of triphenylphosphine as a nucleophile and triethylamine as a base in good to high yields (69-91 %). Evaluation of the synthesized compounds revealed a good to excellent antioxidant activities (37.6-96.
View Article and Find Full Text PDFThe effect of endocervical and catheter bacterial colonisation during fertilisation and embryo transfer (IVF-ET) on IVF success rate among asymptomatic women: a longitudinal prospective study.
J Obstet Gynaecol
February 2022
Article Synopsis
- A recent study examined the impact of bacterial contamination during IVF-ET on asymptomatic women, focusing on those with positive bacterial cultures.
- The research involved 74 women and analyzed pregnancy outcomes, showing no significant differences in biochemical and clinical pregnancy rates between women with positive and negative ET catheter cultures.
- The findings suggest that a positive bacterial culture in the absence of symptoms doesn't increase the risk of IVF failure, indicating a need for further investigation in diverse clinical settings.
Aim: This study aimed to evaluate the effect of piroxicam adjuvant therapy on the clinical and biochemical pregnancy rate in patients undergoing in vitro fertilization (IVF) and frozen-thawed embryo transfer (ET) cycles.
Methods: In a randomized, double-blinded, placebo-controlled clinical trial, 178 patients eligible for IVF-ET received either single dose of piroxicam 1-2 h before frozen-thawed ET or a placebo at the same time. Study participants were then followed and compared regarding the primary outcome of the study, which was biochemical (positive β-human chorionic gonadotrophin test) and clinical pregnancy (detected fetal heart beat in ultrasound) rate.