Publications by authors named "Leila Fonderflick"
Vaccine therapy is a promising method of research to promote T cell immune response and to develop novel antitumor immunotherapy protocols. Accumulating evidence has shown that autophagy is involved in antigen processing and presentation to T cells. In this work, we investigated the potential role of GABARAP and GABARAPL1, two members of the autophagic ATG8 family proteins, as surrogate tumor antigen delivery vectors to prime antitumor T cells.
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- - Early detection and improved treatments for breast cancer have reduced mortality rates, but challenges remain in addressing triple negative breast cancer (TNBC), which currently lacks effective treatments.
- - Researchers studied the expression of six autophagy genes in breast cancer tissues, finding increased levels of a specific gene in TNBC samples, which was also confirmed at the protein level.
- - By inhibiting this gene in TNBC cell lines, the study showed that it plays a role in regulating cancer traits, suggesting it could become a new marker and potential therapeutic target for TNBC in the future.