Mediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naïve schizophrenia.

Background: The elevated prolactin levels in first-episode drug-naïve (FEDN) schizophrenia patients may correlate with long-term stress caused by childhood trauma. This study aimed to assess the relationship between elevated prolactin levels and childhood trauma in FEDN schizophrenia patients, while also considering sex differences.

Methods: Utilizing a cross-sectional design, the study involved 88 FEDN schizophrenia patients and 76 healthy controls (HCs).

Overexpression of ATF4 Inhibits Ferroptosis to Alleviate Anxiety Disorders by Activating the TGF-β Signaling Pathway.

Background: Anxiety disorders seriously impair patients' mental health and quality of life, with limited effectiveness of current treatments. Dysregulation of activating transcription factor 4 (ATF4) is involved in various mental diseases, but the research on its potential roles in alleviating anxiety disorders remains limited.

Methods: ATF4 was screened out by bioinformatic analysis and its expression was verified in vivo.

Enhanced Path Planning and Obstacle Avoidance Based on High-Precision Mapping and Positioning.

High-precision positioning and multi-target detection have been proposed as key technologies for robotic path planning and obstacle avoidance. First, the Cartographer algorithm was used to generate high-quality maps. Then, the iterative nearest point (ICP) and the occupation probability algorithms were combined to scan and match the local point cloud, and the positions and attitudes of the robot were obtained.

Effect of Fusion Boundary Microstructure on Flow-Accelerated Corrosion Cracking.

Flow-accelerated corrosion (FAC) preferentially attacks the downstream heat-affected zone of the root-pass weld in steam pipe systems. A detailed characterization identifies the fusion boundary as the initiation location for the attack. Alloying elements are found depleted along the weld fusion boundary, and multiple welding thermal cycles and repetitive austenite-to-ferrite phase transformations result in an increased proportion of grains with Goss {110}<001> texture along the fusion boundary.

Crack-Tip Opening Displacement of Girth Welds in a Lean X70 Pipeline Steel.

Crack-tip opening displacement (CTOD) tests were conducted on girth welds of two API 5L X70 pipeline steels (pipe A and pipe B) to investigate the influence of base metal composition on the fracture toughness of the joint. CTOD measurements across the weld showed that the weld fusion zone had the lowest CTOD values for both pipes, with pipe B having a higher CTOD value than pipe A. Detailed microstructure characterization of the multi-pass weld showed that the fusion zone in both pipes consisted of three distinct zones: the columnar zone, the coarse equiaxed zone, and the fine equiaxed zone.

Visual Sensing and Depth Perception for Welding Robots and Their Industrial Applications.

With the rapid development of vision sensing, artificial intelligence, and robotics technology, one of the challenges we face is installing more advanced vision sensors on welding robots to achieve intelligent welding manufacturing and obtain high-quality welding components. Depth perception is one of the bottlenecks in the development of welding sensors. This review provides an assessment of active and passive sensing methods for depth perception and classifies and elaborates on the depth perception mechanisms based on monocular vision, binocular vision, and multi-view vision.

Associations of resilience, white matter topological organization, and cognitive functions in first-episode, drug-naïve schizophrenia patients: A moderated mediation analysis.

Background: Cognitive deficits are core symptoms of schizophrenia (SZ) and are associated with impaired resilience to stress. Different cognitive functions appeared to be interrelated, and the mechanism may involve neural alterations. The disrupted topological organization indicated abnormalities in the segregation and integration of brain networks that support various cognitive processes in SZ patients.

DAssd-Net: A Lightweight Steel Surface Defect Detection Model Based on Multi-Branch Dilated Convolution Aggregation and Multi-Domain Perception Detection Head.

During steel production, various defects often appear on the surface of the steel, such as cracks, pores, scars, and inclusions. These defects may seriously decrease steel quality or performance, so how to timely and accurately detect defects has great technical significance. This paper proposes a lightweight model based on multi-branch dilated convolution aggregation and multi-domain perception detection head, DAssd-Net, for steel surface defect detection.

Design and analysis of welding inspection robot.

Periodic inspection, commonly performed by a technician, of weld seam quality is important for assessing equipment reliability. To save labor costs and improve efficiency, an autonomous navigation and inspection robot is developed. The development process involves the design of chassis damping, target detection mechanism, control system, and algorithms.

Effect of the Interaction between Depression and Sleep Disorders on the Stroke Occurrence: An Analysis Based on National Health and Nutritional Examination Survey.

Objective: To investigate the effect of the interaction between depression and sleep disorders on the stroke occurrence based on the data from the National Health and Nutritional Examination Survey (NHANES).

Methods: Seven cycles of 2-year NHANES data (2005-2018) were analyzed in this study. Univariate analysis was first performed between the stroke and nonstroke patients, and then, multivariate logistic regression models were conducted to analyze the association of depression, sleep disorders, and their interactions with stroke occurrence.

Effect of Initial Microstructure on the Toughness of Coarse-Grained Heat-Affected Zone in a Microalloyed Steel.

Toughness of the coarse-grained-heat-affected-zone (CGHAZ) strongly depends on the prior austenite grain size. The prior austenite grain size is affected not only by chemical composition, thermal cycle, and dissolution of second-phase particles, but also by the initial microstructure. The effect of base metal microstructure (ferrite/pearlite obtained by air cooling and martensite obtained by water-quenching) on Charpy impact toughness of the CGHAZ has been investigated for different heat inputs for high-heat input welding of a microalloyed steel.

Specific white matter connectomic changes in schizophrenia compared with psychotic bipolar disorder.

Background: Schizophrenia (SZ) and bipolar disorder with psychosis (BDP) can be clinically confusing. The specific connectomic changes in SZ compared with BDP may lead to a deeper comprehension of the pathophysiological core of SZ. Therefore, this study explored the common and distinct white matter (WM) structural connectomic alterations between these two diseases.

Cascading phase transformations in high carbon steel resulting in the formation of inverse bainite: An atomic scale investigation.

Atom probe tomography (APT) has been used to understand the redistribution of solutes during the isothermal cascading phase transformations from supersaturated austenite resulting in the formation of inverse bainite. Different cascading reactions resulting in the formation of inverse bainite, namely the cementite midrib formation, ferrite formation, secondary cementite formation, and the degenerated microstructure of inverse bainite have been studied in detail. Solute profiles across the different transformation interfaces indicate Negligible Partitioning Local Equilibrium (NPLE) type growth kinetics for cementite midrib, whereas a transition in growth kinetics from Para Equilibrium (PE) to Negligible Partitioning Local Equilibrium (NPLE) is observed for secondary cementite and ferrite transformation.

Factors related to duration of untreated psychosis of first episode schizophrenia spectrum disorder.

Aim: Duration of untreated psychosis (DUP) is associated with outcome and functioning. It is expected that scientists will find factors that modulate DUP, but thus far, research on this topic has shown inconsistent results. Furthermore, similar studies in China are insufficient.

ZNF804A rs1344706 is associated with cortical thickness, surface area, and cortical volume of the unmedicated first episode schizophrenia and healthy controls.

The effects of ZNF804A rs1344706, a prominent susceptibility gene for schizophrenia, on gray matter (GM) structure in unmedicated schizophrenia (SZ) patients are still unknown, although several previous studies investigated the effects in medicated SZ patients and healthy controls (HC). Analyzing cortical thickness, surface area, and GM volume simultaneously may provide a more precise and complete picture of the effects. We genotyped 59 unmedicated first episode SZ patients and 60 healthy controls for the ZNF804A single nucleotide polymorphism (SNP) rs1344706, and examined between-group differences in cortical thickness, surface area, and cortical volume using a full-factorial 2 × 2 analysis of variance (ANOVA).

Disrupted brain anatomical connectivity in medication-naïve patients with first-episode schizophrenia.

Previous studies suggested that the topological properties of brain anatomical networks may be aberrant in schizophrenia (SCZ), and most of them focused on the chronic and antipsychotic-medicated SCZ patients which may introduce various confounding factors due to antipsychotic medication and duration of illness. To avoid those potential confounders, a desirable approach is to select medication-naïve, first-episode schizophrenia (FE-SCZ) patients. In this study, we acquired diffusion tensor imaging datasets from 30 FE-SCZ patients and 34 age- and gender-matched healthy controls.

[A study of cerebral cortex in untreated first-episode schizophrenics].

Objective: To detect the changes of cortical thickness and cortical surface area in untreated patients of first-episode schizophrenia.

Methods: Fifty-seven untreated patients of first-episode schizophrenia (SCZ) hospitalized from September 2009 to March 2012 at Department of Psychiatry, Third Affiliated Hospital, SUN Yat-sen University and 57 healthy controls (HC) recruited by advertising during the same period underwent a high resolution three-dimensional magnetic resonance imaging of brain structures. And cortical-surface based technique was used to analyze the cortical thickness and cortical surface area.

[Diffusion tensor imaging analyses of white matter in healthy siblings of schizophrenics].

Objective: To explore the diffusion tensor imaging (DTI) features of white matter in healthy siblings of schizophrenics.

Methods: Twenty healthy siblings of schizophrenics and 45 healthy controls without a family history of mental disorder. They responded to advertised recruitment during December 2009 and March 2012.

No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: a tract-based spatial statistics study.

Altered brain connectivity has been widely considered as a genetic risk mechanism for schizophrenia. Of the many susceptibility genes identified so far, ZNF804A (rs1344706) is the first common genetic variant associated with schizophrenia on a genome-wide level. Previous fMRI studies have found that carriers of rs1344706 exhibit altered functional connectivity.

[Diffusion tensor imaging analyses of white matter at an early stage of first-episode schizophrenia].

Objective: To explore the roles of diffusion tensor imaging (DTI) of white matter at an early stage of schizophrenia.

Methods: The participants were 20 first-episode, medication-naïve schizophrenics at an early stage (1 - 6 months) and 20 healthy controls adjusted in gender and age during December 2009 and October 2010. They underwent diffusion weighted magnetic resonance imaging with a single-shot echo planar imaging (EPI) sequence aligned to straight axial plane.

The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population.

Schizophrenia is thought to arise in part from abnormal gray matter (GM), which are partly shared by the relatives of the probands. DISC1 is one of the most promising susceptibility genes of schizophrenia and a SNP rs821597 (A) in the gene was associated with schizophrenia in Han Chinese population. In this study, 61 healthy controls and 72 with schizophrenic patients were genotyped at rs821597, and underwent T1-weighted MRI for the density of GM.

[Comparison of white matter integrity of schizophrenic patients with and without impulsive behaviors by diffusion tensor magnetic resonance imaging].

Objective: To compare the regional white matter integrity of schizophrenics with impulsive behaviors versus those without.

Methods: Seventeen patients with first-episode-schizophrenia impulsive behaviors and 24 patients with first-episode-schizophrenia non-impulsive behaviors underwent diffusion weighted magnetic resonance imaging with a single-shot echo planar imaging (EPI) sequence aligned to straight axial plane. The fractional anisotropy (FA) images of two groups received two-sample t-test with SPM5 software.

[Diffusion tensor imaging findings in first-episode and chronic schizophrenics].

Objective: To investigate the integrity of white matters in first-episode and chronic schizophrenics.

Methods: For this study, 39 first-episode and 38 chronic schizophrenics, 69 healthy controls (age, gender and years of received education no significantly different from those of the patients) underwent diffusion weighted images with a single-shot echo planar imaging (EPI) sequence aligned to the straight axial plane. The fractional anisotropy (FA) images of three groups underwent one-way ANOVA with the methods of voxel-based morphometric (VBM) analysis.

Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia.

Background: ZNF804A gene polymorphism rs1344706, the first genetic risk variant to achieve genome wide significance for schizophrenia, has been linked to neural functional connectivity. Dysconnectivity of WM may be the primary pathological mechanism of schizophrenia. Association of this variant with regional WM density has not been investigated in schizophrenic patients.

Effect of substrate dimensions on dynamics of ultrasonic consolidation.

An FEM model is developed for a fundamental study of the time-dependent mechanical behavior of the substrate and its dimensions on ultrasonic consolidation. The simulation shows that for a given vibration condition, the amplitude of contact friction stress and displacement stabilizes to a saturated state after certain number of ultrasonic cycles. With the increased substrate height, the amplitude of contact frictional stress decreases, while that of contact interface displacement increases.