Polymorphic Covalent Organic Frameworks: Molecularly Defined Pore Structures and Iodine Adsorption Property.

Radioactive iodine-capturing materials are urgently needed for the emerging challenges in nuclear waste disposal. The various pore structures of covalent organic frameworks (COFs) render them promising candidates for efficient iodine adsorption. However, the detailed structure-property relationship of COFs in iodine adsorption remains elusive.

Organic Single Crystals with High Photoluminescence Quantum Yields Close to 100% and High Mobility for Optoelectronic Devices.

Organic single crystals with excellent optical and electrical properties are critical for the development of organic optoelectronics. Herein, two compounds 9,10-bis([N,N-diphenyl]-4'-phenylethynyl)anthracene (TPA-An) and 9,10-bis([1',3'-diphenyl]-5'-phenylethynyl)anthracene (TBA-An) are synthesized by introducing two different luminescent groups, triphenylamine and 1,3-diphenylbenzene, at the 9,10 positions of anthracene via triple bond connection. Single crystals based on TPA-An and TBA-An with a ribbon morphology obtained through the slow solvent-evaporation method exhibit high photoluminescence quantum yields (PLQYs) of 98% and 99% at room temperature, and remarkable hole mobilities of 0.

Recent advances in assembled AIEgens for image-guided anticancer therapy.

Image-guided therapy, with simultaneous imaging and therapy functions, has the potential to greatly enhance the therapeutic efficacy of anticancer therapy, and reduce the incidence of side effects. Fluorescence imaging has the advantages of easy operation, abundant signal, high contrast, and fast response for real-time and non-invasive tracking. Luminogens with aggregation-induced emission characteristics (AIEgens) can emit strong luminescence in an aggregate state, which makes them ideal materials to construct applicative fluorophores for fluorescence imaging.

Co-assembly of HPV capsid proteins and aggregation-induced emission fluorogens for improved cell imaging.

In order to improve the cell-imaging ability, and particularly, to extend the bio-application of AIEgen, human papillomavirus (HPV) capsid protein L1 was assembled with the complex of DNA and aggregation-induced emission fluorogen 9,10-distyrylhydrazine (DSAI), where the virus-like particles (VLPs) of HPV encapsulate the complex via electrostatic interaction. The co-assembled nanoparticles, DSAI-DNA@VLPs, showed homogeneous size (∼53 nm), enhanced fluorescence (8 × 2.5-fold), considerable stability (anti-DNase digestion), improved biocompatibility and commendable protection for the DSAI-DNA complex, ensuring virtual brighter imaging in live cells, both for HeLa and normal 293T cell lines.

Label-Free Aptamer-Based Biosensor for Specific Detection of Chloramphenicol Using AIE Probe and Graphene Oxide.

A facile, sensitive, and label-free aptamer-based fluorescent biosensor (aptasensor) for chloramphenicol (CAP) detection was successfully developed based on an aggregation-induced emission (AIE) probe and graphene oxide (GO). In this aptasensor, the specific aptamer of CAP (C-Apt) is used as the recognition part, an AIE molecule, 9,10-distyrylanthracene (DSA) derivative with short alkyl chains (9,10-bis{4-[2-(,,-trimethylammonium)-ethoxy]styrene}anthracene dibromide, DSACN), as the fluorescent probe, and GO with a low oxidation degree as the fluorescent quencher. Initially, the AIE probe DSACN and C-Apt could be adsorbed on GO through π-stacking interactions, and the fluorescence of DSACN could be efficiently quenched due to the energy transfer between DSACN and GO.

Comparative effects of low-dose versus standard-dose alteplase in ischemic patients with prior stroke and/or diabetes mellitus: The ENCHANTED trial.

Background And Purpose: History of prior stroke (PS) and diabetes mellitus (DM) are considered relative contraindications to the use of intravenous alteplase in patients with acute ischemic stroke (AIS). We aimed to assess whether a history of PS and DM modified the comparative effects of low- versus standard-dose alteplase in patients who participated in the alteplase-dose arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED).

Methods: Data from an international, multi-center, prospective, randomized, open-label, blinded-endpoint trial were used to assess the benefits and risks of low (0.

Silica nanoparticles based on an AIE-active molecule for ratiometric detection of RNS in vitro.

Nitric oxide (NO), known as a reactive nitrogen species (RNS), has been considered to be a significant factor in many cell-related biological processes. There is a great desire to develop fluorescent probes that can highly sensitively and selectively detect NO in living cells. Herein, a fluorescent probe, a tetraphenylethene (TPE) derivative TPE-2NH2, with aggregation induced emission (AIE) properties was designed and synthesized.

Magnesium-doped Zinc Oxide as Electron Selective Contact Layers for Efficient Perovskite Solar Cells.

The electron-selective contact layer (ESL) in organometal halide-based perovskite solar cells (PSCs) determines not only the power conversion efficiency (PCE) but also the thermostability of PSCs. To improve the thermostability of ZnO-based PSCs, we developed Mg-doped ZnO [Zn Mg O (ZMO)] as a high optical transmittance ESL for the methylammonium lead trihalide perovskite absorber [CH NH PbI ]. We further investigated the optical and electrical properties of the ESL films with Mg contents of 0-30 mol % and the corresponding devices.

Early prediction of death in acute hypertensive intracerebral hemorrhage.

Hypertensive intracerebral hemorrhage (HICH) has been on the decline. However, mortality at long-term follow up is on the increase. The aim of the present study was to investigate early warning signals of death in patients with acute HICH.