Publications by authors named "Leihong Xiang"

Article Synopsis
  • * The review highlights how skin aging can lead to pigmentary disorders, such as hyperpigmentation (like melasma) and hypopigmentation (like vitiligo).
  • * It discusses the mechanisms behind how aging affects skin pigmentation and proposes possible treatment strategies for managing skin aging and related pigmentary issues.
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Vitiligo is an autoimmune skin disease that targets pigment-producing melanocytes and results in depigmentation. This disfiguring condition frequently affects visible areas of the body and therefore causes a heavy psychological burden and a decreased quality of life. Although remains intractable, the evergrowing understanding of its immunopathogenesis has dramatically shaped the treatment paradigm for vitiligo.

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Article Synopsis
  • PAR2 is a special protein found in the skin that gets activated by certain enzymes and plays a big role in skin inflammation and healing.
  • It helps control things like itching and pain, and is linked to skin problems like acne, rosacea, psoriasis, and eczema.
  • Researchers are looking into new treatments that target PAR2 to help improve these skin conditions.
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Photobiomodulation (PBM) using 830 nm light-emitting diode (LED) benefits tissue regeneration, wound healing and neural stimulation. However, there is not much exploration of its effect on melanocytes and ex vivo skin model. This study aims to investigate the mechanism behind the anti-melanogenic activity of 830 nm LED and provides evidence for its activity in human ex vivo skin model.

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Article Synopsis
  • - FMX101 4% is a topical foam formulation of minocycline approved for treating moderate-to-severe acne vulgaris, and a study was conducted to evaluate its effectiveness and safety among Chinese patients.
  • - In a phase 3 trial involving 372 subjects, results showed that FMX101 4% led to a significant reduction in inflammation lesion count (ILC) and noninflammatory lesion count (nILC), along with a higher treatment success rate compared to a control foam after 12 weeks.
  • - The treatment was generally safe and well-tolerated, with mostly mild-to-moderate side effects and no serious adverse events linked to the treatment.
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Autophagy is a cellular process that functions to maintain intracellular homeostasis via the degradation and recycling of defective organelles or damaged proteins. This dynamic mechanism participates in various biological processes, such as the regulation of cellular differentiation, proliferation, survival, and the modulation of inflammation and immune responses. Recent evidence has demonstrated the involvement of polymorphisms in autophagy-related genes in various skin autoimmune diseases.

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Objective: Salicylic acid (SA) has been used for treatment of acne of different severity levels. However, there are few researches about the safety and efficacy for treatment of mild to moderate acne, and the improvement of the skin condition by using 2% supramolecular salicylic acid (SSA) compared to Davuwen Adapaline gel.

Methods: A multicenter, randomized, assessor-blind and parallel-controlled study was conducted.

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Article Synopsis
  • There is currently no standardized treatment for Riehl's melanosis, a skin condition that can be difficult to manage effectively.
  • This study aimed to compare the effectiveness and safety of combining oral tranexamic acid (TXA) with intense pulsed light (IPL) therapy versus using TXA alone in 28 patients with the condition.
  • Results showed that the combination therapy significantly improved skin pigmentation and patient satisfaction without increased side effects, suggesting it's a safe and effective treatment approach.
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Rosacea is a chronic inflammatory skin disorder characterized by immune response-dependent erythema and pustules. S100A9, a proinflammatory alarmin, has been associated with various inflammation-related diseases. However, the specific role of S100A9 in rosacea remains unexplored.

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Background: Noninvasive energy-based device (NI-EBD) aesthetic procedures has recently gained widespread usage for treating various skin conditions, enhancing skin texture and performing rejuvenation-related procedures. However, practically all NI-EBD procedures result in variable degrees of damage to the skin barrier, inducing pathological and physiological processes such as oxidative stress and inflammation, and only a small percentage of individuals possess the innate ability to restore it.

Objective: To introduce the concept of integrated skincare and establish standardized operational procedures for perioperative integrated skincare, and furnish a theoretical basis for clinical diagnosis and treatment performed by professional medical aestheticians.

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Background: 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for pilosebaceous inflammatory diseases, such as acne vulgaris. In this study, we explored ALA-PDT's mechanisms against acne in vitro.

Methods: We treated human SZ95 sebocytes with ALA (0.

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Integrated skincare combines clinically proven skincare products with professional medical aesthetics to provide a comprehensive solution for beauty pursuers. Studies have demonstrated that a combination of medical aesthetic procedures and maintenance therapies is more effective than either treatment alone. This review outlines the current applications of integrated skincare, including different regimens of energy-based aesthetic devices and active ingredients in cosmeceuticals or chemical peels.

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Electromagnetic radiation, notably visible light (VL), has complicated effects on human skin, particularly pigmentation, which have been largely overlooked. In this review, we discuss the photobiological mechanisms, pathological effects, clinical applications and therapeutic strategies of VL at varying wavelengths on melanocyte biology and skin pigmentary disorders. Different VL wavelengths may impose positive or negative effects, depending on their interactions with specific chromophores, photoaging, ROS production, circadian rhythm and other photon-mediated reactions.

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Inherited epidermolysis bullosa is a heterogeneous group of hereditary skin diseases characterized by skin (mucosa) fragility, which leads to blistering. Junctional epidermolysis bullosa is associated with mutations in genes expressing proteins of the dermo-epidermal junction. Dupilumab, an antibody that directly targets interleukin (IL)-4 receptor alpha, may be an effective treatment for dystrophic epidermolysis bullosa.

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Article Synopsis
  • - Riehl's melanosis is a skin condition characterized by hyperpigmentation, which can affect individuals psychologically and socially, and has seen new classification categories emerging over the past decade.
  • - The exact cause of Riehl's melanosis is uncertain, but it may involve factors like type IV hypersensitivity, genetics, UV exposure, and autoimmune responses, with various diagnostic tools available including dermoscopy and histopathology.
  • - Treatment options have improved and now include topical agents, oral medications, chemical peels, and advanced laser therapies, while recent research also explores biomarkers linked to this condition and other autoimmune diseases.
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Vitiligo is an acquired depigmentary disorder characterized by the depletion of melanocytes in the skin. Mitochondria shoulder multiple functions in cells, such as production of ATP, maintenance of redox balance, initiation of inflammation and regulation of cell death. Increasing evidence has implicated the involvement of mitochondria in the pathogenesis of vitiligo.

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Scleromyxedema is a rare idiopathic fibromucinous disorder characterized by a generalized papular and sclerodermoid cutaneous eruption. Patients often have praraproteinemia and extracutaneous, even lethal, manifestations. Yet the prognostic and therapeutic features of scleromyxedema are poorly documented.

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