Publications by authors named "Leihao Ren"
Background And Purpose: Atypical meningiomas are prevalent intracranial tumors with varied prognoses and recurrence rates. The role of adjuvant radiotherapy (ART) in atypical meningiomas remains debated. This study aimed to develop and validate a prognostic model incorporating machine learning techniques and clinical factors to predict progression-free survival (PFS) in patients with atypical meningiomas and assess the impact of ART.
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- Intracranial angioleiomyoma (IALM) is a rare brain tumor that resembles meningioma, accounting for about 10% of angioleiomyomas and predominantly affecting males, particularly in the orbital and cavernous sinus areas.
- *The study analyzed 40 patients who underwent tumor resection and found that symptoms like vision impairment and diplopia were common, with a significant portion misdiagnosed as meningioma prior to surgery.
- *Postoperative results indicated a clinically benign nature of IALM with no recurrence, and GJA4 mutations were noted in 42.5% of cases, correlating with progesterone receptor expression and suggesting a possible molecular link.
Objective: Psammomatous meningiomas (PMs) are a rare histological subtype of meningioma but are rather frequent in spinal meningiomas. The authors aimed to analyze the incidence, clinical features, molecular alterations, long-term outcomes, and prognostic factors of PMs.
Methods: In total, 151 patients with PMs were included in this study.
Article Synopsis
- The study investigates the distribution of clinically actionable mutations in foramen magnum (FM) meningiomas, which are challenging to surgically treat and have high risks associated with them.
- Targeted next-generation sequencing was performed on 62 FM meningiomas, excluding those related to radiation or neurofibromatosis type 2, and various patient and tumor characteristics were evaluated.
- Results showed that 93.5% of tumors had significant driver mutations, with TRAF7 and AKT1E17K being the most common, and their mutations were linked to specific tumor locations relative to the brainstem.
Purpose: Atypical meningiomas could manifest early recurrence after surgery and even adjuvant radiotherapy. We aimed to construct a clinico-radiomics model to predict post-operative recurrence of atypical meningiomas based on clinicopathological and radiomics features.
Materials And Methods: The study cohort was comprised of 224 patients from two neurosurgical centers.
Objectives: To establish a deep learning (DL) model for predicting tumor grades and expression of pathologic markers of meningioma.
Methods: A total of 1192 meningioma patients from two centers who underwent surgical resection between September 2018 and December 2021 were retrospectively included. The pathological data and post-contrast T1-weight images for each patient were collected.
Background: WHO grade 2 meningiomas, including atypical, chordoid, and clear cell subtypes, form a heterogenous group of meningiomas with varying aggressiveness and clinical behavior.
Objective: To demonstrate the differences of clinical-histopathological characteristics and long-term outcomes among these 3 subtypes.
Methods: A total of 609 consecutive patients diagnosed with WHO grade 2 meningiomas (543 atypical meningiomas [AMs], 36 chordoid meningiomas [CMs], and 30 clear cell meningiomas [CCMs]) from 2010 to 2018 were enrolled in this study.
Objective: Benefits of adjuvant radiotherapy (ART) after gross-total resection (GTR) of de novo atypical meningiomas (AMs) are controversial, and factors predictive of radiotherapy benefits in patients with de novo AMs after GTR are unknown. The authors aimed to evaluate the benefits of ART and explore potential factors sensitizing AMs to ART.
Methods: A total of 231 consecutive patients who were pathologically diagnosed with de novo AMs and treated with GTR (Simpson class I-III resections) from 2010 to 2018 were enrolled in the study.
Purpose: To determine if loss of H3K27me3 could predict higher risk of re-recurrence in recurrent meningiomas.
Methods: A retrospective, single-center cohort study was performed for patients who underwent resection of recurrent grade 1 (N = 132) &2 (N = 32) meningiomas from 2009 to 2013. Association of H3K27me3 staining and clinical parameters was analyzed.
Purpose: This study aimed to investigate the feasibility of predicting mutation status based on the MR radiomic analysis in patients with intracranial meningioma.
Methods: This retrospective study included 105 patients with meningiomas, including 60 -mutant samples and 45 wild-type samples. Radiomic features were extracted from magnetic resonance imaging scans, including T1-weighted, T2-weighted, and contrast T1-weighted images.
Objective: To evaluate the clinicopathological characteristics, radiology, and long-term outcomes of microcystic meningiomas (MM) and compare it with other subtypes of meningiomas managed at a single neurosurgical center.
Methods: A total of 87 consecutive patients who underwent surgical resection and were diagnosed as MM between 2005 and 2016 were enrolled for analysis. Clinicopathological, radiology, and prognostic information was collected and analyzed.
Background: Meningiomas are the most common primary intracranial tumors in adults. According to the 2021 World Health Organization (WHO) classification of central nervous system tumors, approximately 80% of meningiomas are WHO grade 1, that is, histopathologically benign, whereas about 20% are WHO grade 2 or grade 3, showing signs of atypia or malignancy. The dysregulation of N6-methylation (mA) regulators is associated with disorders of diverse critical biological processes in human cancer.
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