Publications by authors named "Leigheb M"
Background/objectives: Chronic pain impacts approximately 18% of the Spanish population, with low levels of vitamin D prevalent in over 80% of individuals over 65. Given vitamin D's critical role in pain modulation, its deficiency may be significantly linked to chronic musculoskeletal pain, though existing research offers mixed results.
Methods: This systematic review followed PRISMA guidelines, examining studies from PubMed, Cochrane, and PEDRO databases from 1990 onwards that investigated the relationship between vitamin D levels and chronic musculoskeletal pain.
Introduction: Radial nerve injury following humeral fracture is the most common peripheral nerve injury associated with long bone fractures. The purpose of this study is to analyse our treatment protocols and long-term outcomes of humeral fractures associated with radial nerve injury which were surgically treated at the I.R.
View Article and Find Full Text PDFForefoot disorders are prevalent in the general population, with an incidence between 2 and 20%. Among them, lesser toe deformities (hammer, claw, and mallet toes) are frequent disorders, and their conservative management is often not adequately considered but usually attempted before surgical indication. Among conservative treatments, shoe modifications and the application of orthoses may, in most cases, alleviate symptoms.
View Article and Find Full Text PDFIntroduction: While titanium and its alloys exhibit excellent biocompatibility and corrosion resistance, their polished surfaces can hinder fast and effective osseointegration and other biological processes, such as angiogenesis, due to their inert and hydrophobic properties. Despite being commonly used for orthopedic implants, research focuses on developing surface treatments to improve osseointegration, promoting cell adhesion and proliferation, as well as increasing protein adsorption capacity. This study explores a chemical treatment intended for titanium-based implants that enhances tissue integration without compromising the mechanical properties of the Ti6Al4V substrate.
View Article and Find Full Text PDFHallux valgus (HV) is a frequent forefoot deformity affecting about 23% of adults and 35.7% of people over 65. The exact etiology is not fully understood.
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- This study examines mechanical complications in hip fracture surgery using the Trochanteric Fixation Nail-Advanced (TFNA) implant, focusing on various risk factors.
- It involved 253 patients with hip fractures treated between 2017 and 2021, ultimately analyzing data from 126 individuals who had at least a 6-month follow-up.
- Key findings reveal that 21.4% experienced mechanical complications, with significant risks linked to certain fracture types, surgical methods, and lack of osteoporosis treatment, indicating a need for better clinical monitoring.
Article Synopsis
- Biomaterials, especially bioactive glasses, are used as substitutes for damaged bone due to their bone-healing properties, but can lead to infections and immune responses post-implantation.
- The study evaluated the effects of adding metallic ions (silver, copper, tellurium) to these glasses on T-cell behavior, discovering that silver decreased cell viability, copper altered immune cell ratios, and tellurium had no negative effects.
- The findings suggest that the changes in T-cell subsets and cytokine levels could lead to interactions with other immune cells, affecting how the body responds to the biomaterial implants.
Article Synopsis
- Human mesenchymal stem cells (hMSCs) respond to mechanical and biophysical signals, with pulsed electromagnetic field (PEMF) stimulation showing promise in treating musculoskeletal disorders and enhancing bone tissue engineering.
- This study examines the effects of PEMF on bone regeneration by creating trabecular bone-like tissues, culturing them in a bioreactor, and analyzing cellular signaling pathways through transcriptomic studies.
- Results indicate that PEMF boosts hMSC immune responses and stimulates processes like angiogenesis and osteogenesis, reflecting key aspects of bone healing, showcasing the potential of the bioreactor platform for future research.
Article Synopsis
- * Diagnosis involves multiple tests, including imaging (CT, MRI, PET), biopsies, and lab work to confirm the presence of kidney metastases.
- * Treatment for CUP with kidney metastases is tailored to individual factors and may include surgery, radiation, and systemic therapies, emphasizing the need for input from a multidisciplinary team of specialists.
Article Synopsis
- * Researchers hypothesized that altering the metabolism of different microglia subsets could enhance their anti-inflammatory effects, presenting a potential treatment strategy for neurodegenerative diseases.
- * The study found that the FDA-approved drug Ranolazine, along with other compounds like Quercetin and Naringenin, can reduce inflammation and neurotoxicity in microglial cells, suggesting these molecules could be useful for therapy without the side effects associated with corticosteroids.
Background: Patellar femoral chondropathy (FPC) is a common problem in patients undergoing anterior cruciate ligament reconstruction (ACL-R) surgery, which, if left untreated, predisposes to arthrosis. Magnetic resonance imaging (MRI) is the non-invasive gold standard for morphological evaluation of cartilage, while in recent years advanced MRI techniques (such as T2 mapping) have been developed to detect early cartilage biochemical changes. This study evaluates the different onset of early PFC between B-TP-B and HT through T2 mapping.
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- - The imbalance between osteoblast (OB) activity and osteoclast (OC) activity leads to osteoporosis by causing a loss of bone mass during remodeling, making OC suppression and OB enhancement potential therapies for aging-related bone issues.
- - The dietary product KYMASIN UP, which contains herbal extracts, was tested and found to decrease OC formation and activity by reducing key signaling pathways associated with their development.
- - KYMASIN UP promotes OB differentiation, increases calcium mineralization in bone cells, and may help restore the balance between OBs and OCs, potentially improving bone quality and reducing healthcare needs for the elderly.
Article Synopsis
- * The study investigated Ranolazine, a metabolic modulator, in aged mice to see if it could improve muscle function and strength.
- * Results showed that Ranolazine boosted muscle strength and promoted positive changes in muscle structure and gene expression, along with enhancing antioxidant systems, suggesting it may help address muscle deterioration in the elderly.
Advance in the Diagnostics and Management of Musculoskeletal Diseases.
Diagnostics (Basel)
June 2022
Article Synopsis
- Musculoskeletal disorders encompass a wide range of conditions that impact the body's muscles, bones, ligaments, and tendons.
- These disorders are prevalent globally, affecting people of all ages and backgrounds.
- They can lead to significant pain, disability, and decreased quality of life, highlighting the need for effective treatment and prevention strategies.
Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders.
Curr Osteoporos Rep
October 2022
Article Synopsis
- The increasing prevalence of musculoskeletal disorders linked to aging is heavily influenced by sedentary lifestyles, leading to negative impacts on quality of life and rising healthcare costs.
- Exercise can serve as a countermeasure to these disorders by enhancing musculoskeletal health and potentially reducing associated health risks.
- Recent research shows that exercise influences the crosstalk between muscle and bone, affecting factors related to inflammation and immune responses, highlighting the need for both exercise and future exercise-mimicking medications in treating these conditions.
Background: Cervical spine manipulations (CSM) have been performed for centuries and are a widely practiced intervention to manage cervical spine musculoskeletal disorders. We aimed to perform an overview of the literature concerning the effects and the adverse events of CSM in the Physical and Rehabilitation Medicine (PRM) field with a forensic medicine perspective.
Methods: A search in the scientific literature (PubMed, Google Scholar, PEDro and Cochrane) was carried out from inception until October 2020.
Article Synopsis
- Rotator cuff tears commonly cause shoulder pain in middle-aged individuals, and treatment must be tailored to each patient's specific situation.
- This study evaluated the medium-term effectiveness of arthroscopic debridement for massive rotator cuff injuries, analyzing patient satisfaction and clinical scores post-surgery.
- Results showed a high satisfaction rate (93%) among patients, with favorable average scores for shoulder function and pain, indicating that debridement is a valid surgical option, especially for patients with preserved shoulder mobility prior to surgery.
Article Synopsis
- A study investigated risk factors for delirium in elderly patients who underwent surgery for hip fractures, revealing that 20% experienced delirium post-operation.
- The study included 83 patients aged 65 and older, excluding those already delusional before surgery, and assessed various factors on different postoperative days.
- Key findings indicated that advanced age, use of specific medications, and certain comorbidities were significantly associated with the occurrence of delirium, suggesting the need for careful monitoring of at-risk patients.
Article Synopsis
- Rhizarthrosis affects 10% of arthritic cases, increasing with age and more common in women, often leading to joint complications in the hand.
- This study reviews the outcomes of 32 patients with advanced rhizarthrosis who underwent a modified surgical procedure called trapeziectomy, without correcting hyperextension issues in the MCP joint.
- Results showed positive clinical outcomes, with significant pain reduction and satisfactory hand function, indicating that the lack of MCP joint correction is acceptable in cases where hyperextension is less than 15 degrees.
Match Analysis, Physical Training, Risk of Injury and Rehabilitation in Padel: Overview of the Literature.
Int J Environ Res Public Health
March 2022
Article Synopsis
- * A review of 19 studies examined game dynamics, injury rates, and rehabilitation strategies, highlighting high injury risks due to intense movements like sudden direction changes.
- * The inconsistency in existing research limits definitive conclusions, emphasizing the need for further studies to better understand injury mechanisms and improve rehabilitation approaches.
Article Synopsis
- Functional ability is crucial for healthy aging, and articular cartilage degeneration significantly impacts life quality, being a major contributor to osteoarthritis (OA).
- The limited self-repair capacity of articular cartilage and unsatisfactory results from current treatments highlight the need for innovative tissue engineering methods for repair.
- This literature review summarizes recent advancements in both cell-based and cell-free techniques for articular cartilage repair and evaluates various study models to present a comprehensive overview of current findings and their clinical relevance for OA.
Article Synopsis
- Sarcopenia is a condition marked by decreased muscle mass and strength, and this study looked into using muscle ultrasound to help diagnose it.
- The focus was on the tibialis anterior muscle in people undergoing hip replacements, comparing results with a healthy control group and measuring parameters like muscle thickness and hand grip strength.
- Results showed that ultrasound could reliably assess muscle thickness and correlate strongly with measures of quality of life and muscle strength, suggesting it could be a useful tool in diagnosing sarcopenia.
Article Synopsis
- Arthroscopy is increasingly popular for its minimally-invasive approach, but it can lead to nerve injuries that have significant economic, psychological, and legal consequences for both patients and surgeons.
- A review of medical literature identified that nerve injuries during arthroscopic procedures often occur due to direct damage when creating portals or during surgical maneuvers, as well as from indirect factors like pressure or poor patient positioning.
- To minimize these risks, strict adherence to surgical techniques and patient positioning guidelines is essential, and if nerve injury occurs, a waiting period of 6 months before considering surgical revision is recommended, along with regular physiotherapy and assessments.
Article Synopsis
- The study reviews the effectiveness of MRI in diagnosing acute injuries to the anterior talo-fibular ligament (ATFL), as most previous research focused on chronic injuries and symptoms.
- Seven relevant studies were analyzed, revealing that MRI has high sensitivity and specificity for diagnosing acute ATFL injuries, with pooled sensitivity at 1.0 and specificity at 0.9.
- The findings suggest that while MRI is accurate and could be beneficial for diagnosing acute cases, its high cost often prevents its use in clinical settings.
Article Synopsis
- Fractures of the proximal femur are common in elderly patients and lead to serious health issues, including high mortality rates and reduced independence in daily activities.
- *Timing for surgery is crucial, with early operations (within 48 hours) linked to better outcomes, lower complications, and decreased mortality compared to conservative treatments.
- *A comprehensive transdisciplinary approach is essential for improving care and outcomes, but coordination among various healthcare professionals remains a challenge due to the complexity involved.