The Importance of a Recovery Friendly Environment Following Treatment for Substance Use Disorder: A Setup for Successful Reentry for Health Care Professionals.

Substance use disorder (SUD) continues to be a public health concern for state boards of nursing and returning to work after treatment can be a challenging experience. A Recovery Friendly Workplace (RFW) supports the workplace community by recognizing recovery from SUD as a strength and the willingness to work intentionally with people in recovery. RFW fosters an environment that encourages healthy and safety among employees to decrease barriers for those impacted by SUD.

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells.

The development of resistance and the activation of bypass pathway signalling represents a major problem for the clinical application of protein kinase inhibitors. While investigating the effect of either a c-Rel deletion or RelAT505A phosphosite knockin on the Eµ-Myc mouse model of B-cell lymphoma, we discovered that both NF-κB subunit mutations resulted in CHK1 inhibitor resistance, arising from either loss or alteration of CHK1 activity, respectively. However, since Eµ-Myc lymphomas depend on CHK1 activity to cope with high levels of DNA replication stress and consequent genomic instability, it was not clear how these mutant NF-κB subunit lymphomas were able to survive.

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.

Previously, we discovered that deletion of c-Rel in the Eµ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the expected function of this NF-κB subunit in B-cell malignancies. Here we report that Eµ-Myc/cRel-/- cells have an unexpected and major defect in the CHK1 pathway. Total and phospho proteomic analysis revealed that Eµ-Myc/cRel-/- lymphomas highly resemble wild-type (WT) Eµ-Myc lymphomas treated with an acute dose of the CHK1 inhibitor (CHK1i) CCT244747.

Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.

Objective: To estimate the risk of maternal and neonatal sepsis associated with chorioamnionitis.

Data Sources: PubMed, BIOSIS, and ClinicalTrials.gov databases were systematically searched for full-text articles in English from inception until May 11, 2020.

Choose who's in your circle: how women's relationship actions during and following residential treatment help create recovery-oriented networks.

Women in recovery from substance use disorders often have difficulty establishing recovery-supportive networks. This exploratory study uses qualitative thematic analysis to examine how 88 women in recovery describe the actions they take to manage their personal social networks 12 months after intake into residential substance use treatment. Participants describe disconnecting or limiting contact with recovery-endangering people and adding recovery-supportive people to their networks as primary relationship actions for maintaining recovery.

Substance Abuse and Misuse Identification and Prevention: An Evidence-Based Protocol for CRNAs in the Workplace.

Healthcare providers are susceptible to substance abuse, and anesthesia personnel are some of the most vulnerable. Substance abuse is the principal cause of professional impairment for Certified Registered Nurse Anesthetists (CRNAs), with 1 of 10 experiencing addiction to drugs or alcohol. Despite this problem, there is no standardized screening protocol for the identification of substance abuse or misuse for CRNAs.

Plasma volume variation across the menstrual cycle among healthy women of reproductive age: A prospective cohort study.

Increases in reproductive hormones like estrogen, play an important role in the remarkable increases in plasma volume observed in pregnancy. Accurate estimates of plasma volume expansion during pregnancy depend on correctly timing and measuring plasma volume in nonpregnant women. However, to date, there is no consensus on the pattern of plasma volume across the menstrual cycle.

Pharmacist Assisted Medication Program Enhancing the Regulation of Diabetes (PAMPERED) study.

Objectives: To demonstrate that pharmacists working with physicians and other providers in an ambulatory care setting can improve glucose, blood pressure, and lipid control for patients with type 2 diabetes and to report patient adherence to screening and general preventive measures.

Design: Prospective, randomized, clinical practice study.

Setting: Burlington, MA, between January 2001 and August 2003.

The influence of natural organic matter on the toxicity of multiwalled carbon nanotubes.

Engineered carbon nanostructures, such as multiwalled carbon nanotubes (MWNTs), are inherently hydrophobic and are not readily stable in aqueous media. However, the aqueous stability and bioavailability of these nanotubes may be influenced by the water quality parameters such as ionic strength, pH, and natural organic matter (NOM). Natural organic matter adsorbs onto the surface of MWNTs, effectively covering the hydrophobic surface and resulting in increased aqueous stability.

Removable rigid dressings: a retrospective case-note audit to determine the validity of post-amputation application.

This study investigated the validity of post-amputation application of removable rigid dressings (RRDs) for trans-tibial amputees, regarding preparation for prosthetic management and key rehabilitation timelines. It was hypothesised that the use of RRDs would result in faster preparation of the residual limb for prosthetic management and shorter rehabilitation times, compared with conventional soft dressings. A retrospective case-note audit was conducted, in which consecutive trans-tibial amputees who underwent amputation in the 2 years before RRD implementation (non-RRD group, n = 37) and in the 2 years after RRD implementation (RRD group, n = 28) were eligible for inclusion.

Activity levels among lower-limb amputees: self-report versus step activity monitor.

Objective: To determine the accuracy of self-reported activity by community-dwelling, lower-limb amputees.

Design: Descriptive study.

Setting: A regional prosthetics outpatient service.

Business leadership as a spiritual discipline.

What motivates organizational leaders in their search for spirituality? They seek to integrate their inner journey with their day-to-day professional roles. This article describes how a course in spirituality for executives has provided tools to analyze and clarify intentions, avoid the traps of excessive greed and power, and make decisions that are both compassionate and effective. André L.

Buffered lidocaine: analgesia for intravenous line placement in children.

Objectives: To evaluate the effectiveness of intradermal buffered lidocaine as analgesia before intravenous line (i.v.) placement in children.