Mechanistic insights into robust cardiac I potassium channel activation by aromatic polyunsaturated fatty acid analogues.

Voltage-gated potassium (K) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. K channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for example, result in membrane hyperexcitability, a characteristic of epilepsy and cardiac arrhythmias.

Mechanistic insights into robust cardiac I potassium channel activation by aromatic polyunsaturated fatty acid analogues.

Voltage-gated potassium (K ) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. K channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for example, result in membrane hyperexcitability, a characteristic of epilepsy and cardiac arrhythmias.