Publications by authors named "Leif Laakso"
Article Synopsis
- Lactoquinomycin and related compounds are identified as selective inhibitors of the AKT kinase, which is important in cancer cell signaling.
- Synthetic versions of these compounds were created, helping to outline their minimal active features and initial structure-activity relationships (SAR).
- The compounds show effectiveness against human tumor cells with active AKT and support a proposed mechanism where they work by bioreductive alkylation.
Modification of alpha-biphenylsulfonamidocarboxylic acids led to potent and selective MMP-13 inhibitors. Compound 16 showed 100% oral bioavailability in rats and demonstrated >50% inhibition of bovine cartilage degradation at 10 ng/mL.
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