Novel candidate plasma proteins for the pathogenesis and treatment of atopic dermatitis revealed by proteome-wide association study.

Atopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). However, current studies reveal the underlying mechanisms of these loci in the pathogenesis of AD inadequately.

Cerebral structural alterations in the patients undergoing postherpetic neuralgia: A VBM-MRI study.

This study aimed to investigate the changes in gray matter (GM) volume and density in patients with postherpetic neuralgia (PHN). Using voxel-based morphometry (VBM), the differences in cerebral GM volume and concentration between 25 PHN patients and 25 healthy controls with similar gender ratios, ages, and education were compared. Meanwhile, correlation analysis was performed between the value of GM volume/concentration in the brain areas with discrepancy and the visual analog scale (VAS) score/lesion duration.

[Microbial Diversity and Community Analysis of Dental Plaques in Orthodontic Patients Wearing Invisible Appliances and Fixed Appliances].

Objective: To explore the microbial diversity and community structure of dental plaques in orthodontic patients with invisible appliances and fixed appliances and to study the differences.

Methods: Ten orthodontic patients wearing invisible appliances (I) and ten wearing fixed appliances (F) were recruited. Dental plaques were collected from both buccal (B) and lingual (L) sides.

[1 Promoted the Proliferation and Migration Ability of BMSCs in Glioma C6 Microenvironment].

Objective: To investigate the changes in the proliferation and migration ability of bone marrow mesenchymal stem cells (BMSCs) after indirect co-culturing with glioma C6 cells, and to examine the role of plasmacytoma variant translocation 1 gene ( 1), a long non-coding RNA (lncRNA), in these changes.

Methods: After separation, cultivation and identification of BMSCs, BMSCs of good growth condition were picked out and indirectly co-cultured with glioma C6 cells in Transwell chambers. These cells are henceforth referred to as the co-culture group.

[Study on the Expression of 6 of Osteoblast in Diabetic Environment].

Objective: To investigate the ability of osteogenic differentiation and the expression of histone demethylases KDM6B in bone marrow mesenchymal stem cells (BMSCs) in diabetic environment.

Methods: Diabetic model rats was successfully established, and BMSCs from diabetic model rats and normal rats were isolated and cultured for further study. When cultured cells, we added high concentration of glucose and advanced glycosylation products (AGE) in the medium to imitating the diabetic environment.

[Effects of Bisphosphonates on Beclin1 and LC3Ⅱ Induced by High-glucose in Rat Bone Marrow Mesenchymal Stem Cells].

Objective: To investigate the effects of bisphosphonates on autophagy induced by high-glucose in rat bone marrow mesenchymal stem cells (BMSCs).

Methods: BMSCs were isolated and cultured , identified by undergoing osteogenic/chondrogenic/adipogenic differentiation, the concentration of bisphosphonates was determined by CCK-8 method. The cells were cultured in normal glucose (5.

[Study on the Characteristics of Bone in Type-2 Diabetic Rats by Micro-CT].

Objectives: To study the characteristics of bone in type 2 diabetic rats using micro-CT.

Methods: Sixteen male Sprague Dawley(SD) rats, aged 8 week-old, were randomly divided into normal group and experimental group ( =10). Afer being fed with high-fat chow, the rats in experimental group were given low-dose streptozotocin (STZ,30 mg/kg) to induce type 2 diabetic disease.

[Effects of Different Concentrations of Glucose on the Osteogenic Differentiation of Orofacial Bone Mesenchymal Stem Cells].

Objectives: To determine the effects of different concentrations of glucose on the proliferation and osteogenic differentiation of orofacial bonemesenchymal stem cells (OFMSCs).

Methods: OFMSCs were primarily cultured and identified to undergo osteogenic/adipogenic/chondrogenic differentiation. The cells were exposed to osteogenic medium containing different levels of glucose: 5.

Morphologic Analysis of the Temporomandibular Joint Between Patients With Facial Asymmetry and Asymptomatic Subjects by 2D and 3D Evaluation: A Preliminary Study.

Signs and symptoms of temporomandibular joint (TMJ) dysfunction are commonly found in patients with facial asymmetry. Previous studies on the TMJ position have been limited to 2-dimensional (2D) radiographs, computed tomography (CT), or cone-beam computed tomography (CBCT). The purpose of this study was to compare the differences of TMJ position by using 2D CBCT and 3D model measurement methods.

The efficacy and safety of panitumumab in the treatment of patients with metastatic colorectal cancer: a meta-analysis from five randomized controlled trials.

Background: The efficacy of adding panitumumab to chemotherapy remains controversial in the treatment of metastatic colorectal cancer (mCRC). Thus, we conducted this meta-analysis to assess the efficacy and safety of this combination regimen in patients with mCRC.

Methods: The PubMed, Embase, and Web of Science databases were comprehensively searched.

Differences in the mandibular premolar positions in Angle Class I subjects with different vertical facial types: A cone-beam computed tomography study.

Objective: To compare the positions of the mandibular premolars in Angle Class I subjects according to vertical facial type. The results will provide a theoretical basis for predicting effective tooth movement in orthodontic treatment.

Methods: Cephalometric parameters were determined using cone-beam computed tomography in 120 Angle Class I subjects.

[Influence of healing process of extraction on related growth factors in microscrew-bone interface of implanted titanium microscrews near the extraction wounds].

Objective: To detect the expression of growth factors relating to bone reconstructions in microscrew-bone interface of implanted titanium microscrews near the extraction wounds, and to determine the influence of healing process on the growth factors.

Methods: Eight male Beagle dogs (age 18 months) were divided into experimental and control groups. Titanium microscrews were implanted near an extraction wound in the dogs in the experimental group, while the controls had implantation without extraction wounds.

Processing environmental stimuli in paranoid schizophrenia: recognizing facial emotions and performing executive functions.

Objective: To study the contribution of executive function to abnormal recognition of facial expressions of emotion in schizophrenia patients.

Methods: Abnormal recognition of facial expressions of emotion was assayed according to Japanese and Caucasian facial expressions of emotion (JACFEE), Wisconsin card sorting test (WCST), positive and negative symptom scale, and Hamilton anxiety and depression scale, respectively, in 88 paranoid schizophrenia patients and 75 healthy volunteers.

Results: Patients scored higher on the Positive and Negative Symptom Scale and the Hamilton Anxiety and Depression Scales, displayed lower JACFEE recognition accuracies and poorer WCST performances.

[Genetic analysis and gene mapping of DDF1, a pleiotropic gene involving in both vegetable and reproductive growth in rice].

There are many pleiotropic genes playing key roles in regulating both vegetative growth and reproductive development in plants. A dwarf mutant of rice with deformed flowers, named as ddf1, was identified from indica rice breeding lines. Genetic analysis indicated that ddf1 was resulted from the recessive mutation of a single gene, temporarily named as DDF1.

[Event-related potentials P₃₀₀ with memory function and psychopathology in first-episode paranoid schizophrenia].

Objective: To investigate the variability of event-related potentials P(300) and the relationship with memory function/psychopathology in patients with first-episode paranoid schizophrenia.

Methods: Thirty patients with first-episode paranoid schizophrenia (patient group) and twenty health subjects (control group) were enrolled in the study. The auditory event-related potentials P₃₀₀ at the scalp electrodes Cz, Pz and Wechsler Memory Scale (WMS) were examined in both groups, Positive And Negative Syndrome Scale (PANSS) was evaluated in patient group.

[Histological study of miniscrew implanted in lower mandibles of juvenile and adult Beagle dogs].

Objective: To examine the histological discrepancies between juvenile and adult Beagle dogs at different concrescence times after miniscrew implants.

Methods: Miniscrew implants were performed in six juvenile Beagle dogs and six adult Beagle dogs. The space between the fourth premolar root and first molar root, and the spaces in distal and mesial of M1 root were picked up for the implants of the 48 miniscrews.

EEG coherence characteristics at rest and during a three-level working memory task in normal aging and mild cognitive impairment.

Background: The aim was to examine and compare the characteristics of intra- and inter-hemispheric EEG coherence in patients with mild cognitive impairment (MCI) and healthy controls at rest and during a working memory (WM) task having three levels.

Material/methods: The subjects included 35 patients with MCI according to the DSM-IV criteria (mean age: 62.3+/-6.

Alpha spectral power and coherence in the patients with mild cognitive impairment during a three-level working memory task.

Objective: The functional relationship between calculated alpha band spectral power and inter-/intra-hemispheric coherence during a three-level working memory task of patients with mild cognitive impairment (MCI) was investigated.

Methods: Subjects included 35 MCI patients according to the DSM-IV criteria (mean age: 62.3, SD: 6.

[Time varied stress effects on the proliferation of myoblast in rats].

Objective: To investigate the effects of time varied stress on the proliferation of myoblast in rats and provide the basic experimental data for the remodeling of tissue in functional orthopaedics.

Methods: Based on the pulsatile mechanical system founded, this study loaded different strain (2.5, 5.

[Establishment of malodor model and its effects on identifying the halitosis-related bacteria].

Objective: To establish a salivary sediment malodor system, and to evaluate the effect of several kinds of bacteria dedicated to the halitosis formation, hence to identify halitosis-correlated bacteria.

Methods: The proportion of the supernatant and sediment, gained from centrifugal whole saliva, was adjusted to establish a salivary sediment malodor system incubated in facultative aerobic environment under 37 degrees C for 7 hours. The halitosis indexes in both gaseous phase and liquid phase were checked by direct sniffing, and volatile sulphur compounds (VSCs) and pH were determined by halimeter and glass electrode respectively between hours to evaluate the malodor formation.

[Time varied stress effects on the shape-alteration of myoblast in rats].

Objective: To investigate the effects of time varied stress on the shape-alteration of myoblast in rats and to provide a theoretic base to determine the mechanics of myoblast in orthodontic therapy.

Methods: Based on the pulsatile mechanical system our group founded, this study loaded different strain (2.5 kPa, 5.

Inter- and intra-hemispheric EEG coherence in patients with mild cognitive impairment at rest and during working memory task.

Objective: To assess functional relationship by calculating inter- and intra-hemispheric electroencephalography (EEG) coherence at rest and during a working memory task of patients with mild cognitive impairment (MCI).

Methods: The sample consisted of 69 subjects: 35 patients (n=17 males, n=18 females; 52-71 years old) and 34 normal controls (n=17 males, n=17 females; 51~63 years old). Mini-mental state examination (MMSE) of two groups revealed that the scores of MCI patients did not differ significantly from those of normal controls (P>0.

[Analysis of psychological condition of parents with cleft lip and/or palate children].

Objective: To evaluate the psychological situations of cleft lip and/or palate children's parents, to discuss the relationship between psychological situations and cleft types, and to provide clinical treatment to improve the psychological situations of these parents.

Methods: 100 parents whose children were proceeded the primary surgery treatment were selected as the study group, and other 34 parents whose children were normal as the control group. All parents were inquired and tested by the life event scale (LES) and self-rating anxiety scale (SAS).

Hemodynamic changes in depressive patients.

Objective: This study is aimed at exploring the relationship between hemodynamic changes and depressive and anxious symptom in depression patients.

Methods: The cardiac function indices including the left stroke index (LSI), ejection fraction (EF), heart rate (HR), diastolic pressure mean (DPM), systolic pressure mean (SPM), left ventricle end-diastolic volume (LVDV), effective circulating volume (ECV), resistance total mean (RTM) and blood flow smooth degree (BFSD) were determined in 65 patients with major depressive disorders and 31 healthy normal controls. The clinical symptoms were assessed with Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA).

[Study on anxiety and depressive disorder of inpatients in general hospital].

Objective: To assess the co-morbidity of anxiety and depression in hospitalized patients and to analyze the degree of symptoms and the influential factors.

Methods: Thirty patients with malignant tumor were injected with thymosin alpha 1 subcutaneously at the dose of 1.6 mg q.