Publications by authors named "Lei-lei Wu"
Polyoxometalates (POMs) are a class of anionic metal-oxygen clusters with versatile biological activities. Over the past decade, an increasing number of POMs, especially Sb-rich POMs, have been proven to exert antitumor activity. However, the antitumor effects and mechanisms of POMs in the treatment of non-small cell lung cancer (NSCLC) remain largely unexplored.
View Article and Find Full Text PDFThis population-based analysis aimed to explore the associations among marital status, prognosis and treatment of stage I non-small-cell lung cancer. The propensity score matching (PSM), logistic regression and Cox proportional hazards model were used in this study. A total of 13,937 patients were included.
View Article and Find Full Text PDFThe feasibility of surgery after immunotherapy for mediastinal liposarcoma remains uncertain. Besides, the case of immunotherapy for liposarcoma is still lacking. We report a case of recurrence after resection of a left mediastinal liposarcoma.
View Article and Find Full Text PDFObjective: This study aimed to construct a model based on 23 enrolled molecules to evaluate prognoses of pT2/3N0M0 esophageal squamous cell carcinoma (ESCC) patients with up to 20 years of follow-up.
Methods: The lasso-Cox model was used to identify the candidate molecule. A nomogram was conducted to develop the survival model (molecular score, MS) based on the molecular features.
Objectives: The 9th edition of tumour-node-metastasis (TNM) staging for lung cancer was announced by Prof Hisao Asamura at the 2023 World Conference on Lung Cancer in Singapore. The purpose of this study was to externally validate and compare the latest staging of lung cancer.
Methods: We collected 19 193 patients with stage IA-IIIA non-small cell lung cancer (NSCLC) who underwent lobectomy from the Surveillance, Epidemiology and End Results database.
Article Synopsis
- This study explored the prevalence and prognostic impact of BRAF mutations in early-stage lung adenocarcinoma (LUAD) patients, revealing that only 5.6% had these mutations.
- The researchers analyzed data from over 2,000 patients and found that BRAF mutations did not significantly affect recurrence-free survival (RFS) compared to patients without these mutations.
- The findings suggest that BRAF mutation status may not serve as a reliable prognostic indicator for stage I LUAD patients, highlighting the need for further research to confirm these results.
Article Synopsis
- Intratumoral immune status plays a crucial role in how patients with intrahepatic cholangiocarcinoma respond to therapy, especially with a combination of gemcitabine, oxaliplatin, lenvatinib, and anti-PD1 antibody.
- High levels of certain CD8 T-cell markers (GZMB and proliferating CD8) and low levels of Macro CD5L predict better therapeutic responses, while shifts in T-cell markers indicate varying response levels.
- The study also suggests that using anti-CTLA4 antibody can counteract therapy resistance caused by immune exhaustion, paving the way for more effective cancer treatments based on immune profiling.
Article Synopsis
- The study aimed to identify high-risk patients with pathologic stage I lung adenocarcinoma (LUAD) and evaluate the effectiveness of adjuvant chemotherapy (ACT).
- Four key indicators were found to be associated with a higher risk of cancer recurrence, which included age (≥62 years), visceral pleural invasion (VPI), and lymphovascular invasion (LVI).
- In high-risk patients who received ACT, there was a significant improvement in recurrence-free survival and overall survival compared to those who didn't receive it, while the same was not observed in low-risk patients.
Prognostic evaluation of stage I lung adenocarcinoma based on systematic inflammatory response.
JNCI Cancer Spectr
October 2023
Background: This study aimed to construct an effective nomogram based on the clinical and laboratory characteristics to predict the prognosis of stage I lung adenocarcinoma with EGFR alteration.
Methods: A retrospective study was performed of 913 eligible patients with EGFR alteration after surgery at Shanghai Pulmonary Hospital. The peripheral blood indicators were included in the nomogram.
The clinical-histologic and prognostic characteristics in patients with a second primary non-small-cell lung cancer after a lobectomy.
Interdiscip Cardiovasc Thorac Surg
September 2023
Article Synopsis
- This study aimed to determine if surgery benefits patients with a second primary non-small-cell lung cancer (NSCLC) after they’ve had a lobectomy for the first NSCLC, and to identify factors affecting their survival.
- Data from 944 patients were analyzed, revealing that those who had surgery for their second NSCLC had a median survival of 52 months compared to 33 months for those who did not, indicating a significant survival advantage.
- Lobectomy was found to be the most effective surgical option, but in cases where the tumor is 20 mm or smaller, both lobar and sublobar resections provided similar survival benefits.
Article Synopsis
- Developed a nomogram to predict recurrence-free survival (RFS) and overall survival (OS) in patients with early-stage lung adenocarcinoma (ADC) by analyzing clinical and laboratory data.
- Included 1585 surgery patients and validated the model using various statistical methods, showing strong agreement between predictions and actual outcomes.
- The nomogram demonstrated good predictive capability with a concordance index of 0.736, identifying significant risk differences in survival rates between high-risk and low-risk patient groups.
Background: Glioma is a lethal brain cancer and lacking effective therapies. Challenges include no effective therapeutic target, intra- and intertumoral heterogeneity, inadequate effective drugs, and an immunosuppressive microenvironment, etc. Deciphering the pathogenesis of gliomas and finding out the working mechanisms are urgent and necessary for glioma treatment.
View Article and Find Full Text PDFFerroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012. Induced by iron overload and ROS accumulation, ferroptosis is modulated by various cellular metabolic and signaling pathways. The GSH-GPX4 pathway, the FSP1-CoQ10 pathway, the GCH1-BH4 pathway, the DHODH-CoQH2 system and the sex hormones suppress ferroptosis.
View Article and Find Full Text PDFBackground: The current nodal (pN) classification still has limitations in stratifying the prognosis of small cell lung cancer (SCLC) patients with pathological classifications T1-2N0-2M0. Thus. This study aimed to develop and validate a modified nodal classification based on a multicenter cohort.
View Article and Find Full Text PDFArticle Synopsis
- Lung cancer, particularly lung adenocarcinoma (LUAD), is a major health concern, being highly diagnosed and the leading cause of cancer mortality; however, current lymph node dissection methods after surgery are inadequate.
- Researchers analyzed clinical data from 2,696 LUAD patients who underwent systematic lymph node dissection (SLND) to identify factors influencing pathological lymph node status (pN) and created a predictive model.
- The model displayed strong performance metrics, indicating its utility in predicting pN status and helping to refine treatment strategies for patients with small, single tumors (≤5 cm) without the need for SLND.
Article Synopsis
- Researchers developed the Esorisk prognostic model by integrating clinical factors and hematological indicators to predict outcomes for esophageal squamous cell carcinoma (ESCC) patients post-surgery.
- The study examined 996 patients and categorized them into low, middle, and high-risk groups based on their Esorisk scores, revealing a significant correlation between these scores and cancer-specific survival (CSS).
- Results demonstrated that higher Esorisk scores were associated with lower five-year CSS rates, indicating the model's effectiveness in guiding patient prognosis and treatment decisions.
Background: The efficacy of monotherapy of AMG-510 is limited. This study explored whether the AMG-510 and cisplatin combination increases the anti-tumor effect in lung adenocarcinoma with the mutation of Kirsten rat sarcoma viral oncogene (KRAS) G12C.
Methods: Patients' data were used to analyze the proportion of KRAS G12C mutation.
Objective: To compare the short-term clinical efficacy and radiologic differences between oblique lateral interbody fusion(OLIF) and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for degenerative lumbar spondylolisthesis.
Methods: A retrospective analysis was performed on 58 patients with lumbar spondylolisthesis treated with OLIF or MIS-TLIF from April 2019 to October 2020. Among them, 28 patients were treated with OLIF (OLIF group), including 15 males and 13 females aged 47 to 84 years old with an average age of (63.
Background: Glioma is the most lethal and most aggressive brain cancer, and currently there is no effective treatment. Cancer immunotherapy is an advanced therapy by manipulating immune cells to attack cancer cells and it has been studied a lot in glioma treatment. Targeting the immune checkpoint CD47 or blocking the CD47-SIRPα axis can effectively eliminate glioma cancer cells but also brings side effects such as anemia.
View Article and Find Full Text PDFThis study aimed to construct an effective nomogram based on the clinical and oxidative stress-related characteristics to predict the prognosis of stage I lung adenocarcinoma (LUAD). A retrospective study was performed on 955 eligible patients with stage I LUAD after surgery at our hospital. The relationship between systematic-oxidative-stress biomarkers and the prognosis was analyzed.
View Article and Find Full Text PDFUnlabelled: The eighth TNM staging system proposal classifies lung cancer with partial or complete atelectasis/obstructive pneumonia into the T2 category. We aimed to develop nomograms to predict the possibility of lymph node metastasis (LNM) and the prognosis for NSCLC based on atelectasis and obstructive pneumonitis.
Methods: NSCLC patients over 20 years old diagnosed between 2004 and 2015 were selected from the Surveillance, Epidemiology, and End Results (SEER) database.
An Overview: The Diversified Role of Mitochondria in Cancer Metabolism.
Int J Biol Sci
February 2023
Mitochondria are intracellular organelles involved in energy production, cell metabolism and cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism and nucleic acid metabolism, but also in tumor development and metastasis. Mutations in mtDNA are commonly found in cancer cells to promote the rewiring of bioenergetics and biosynthesis, various metabolites especially oncometabolites in mitochondria regulate tumor metabolism and progression.
View Article and Find Full Text PDFBackground: The study on skip-N2 metastasis in small-cell lung cancer (SCLC) is lacking. Therefore, this study aimed to explore the prognostic significance of skip-N2 metastasis based on a multicenter cohort.
Methods: We collected 176 SCLC patients with pathological categories T1-4N1-2M0 from four hospitals in China.