Publications by authors named "Lei-Chang Zhang"
Article Synopsis
- - The study explores the anticancer effects of Modified Huoluo Xiaoling Pills on colorectal cancer (CRC) through network pharmacology and molecular docking to identify potential targets and signaling pathways involved in their action.
- - Using tools like Cytoscape and STRING, researchers identified 242 active ingredients associated with the pills and 1,844 CRC-related targets, highlighting significant pathways such as PI3K-Akt and Wnt.
- - Experimental results demonstrated that Modified Huoluo Xiaoling Pills notably reduced the proliferation and invasiveness of HCT 116 colorectal cancer cells, alongside alterations in key protein expressions related to cancer progression.
Article Synopsis
- The study aimed to evaluate the effects of medicated thread moxibustion, a traditional Zhuang Minority medical practice, on the Th17/IL-17F signaling pathway in rats with ulcerative colitis (UC) to understand its beneficial mechanisms.
- Forty male rats were divided into four groups: normal control, model, medication (treated with salazosulfapyridine), and medicated thread moxibustion (MTM), observing various health indicators after UC was induced.
- Results showed increased levels of Th17 cells and IL-17F in the UC model group, but these levels decreased after treatment in both the medication and MTM groups, indicating effective intervention with no significant differences between the two treatment methods.
Objective: To observe the clinical effect and safety of Sulfasalazine (SASP) combined with ZHUANG medicine mediated thread moxibustion (ZMMTM) for patients with mild and moderate ulcerative colitis (UC).
Methods: A total of 46 UC patients were randomly and equally divided into moxibustion group (SASP combined with ZMMTM) and SASP medication group. Patients of both groups were treated by oral administration of SASP (1 g, tid) for six weeks.
Aims: Diabetic nephropathy (DN) is the major cause for end-stage renal disease (ESRD) and the pathogenesis for DN developing into ESRD is not clear at present. Results from published studies on the relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and ESRD risk in DN patients are still conflicting. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD risk in DN patients.
View Article and Find Full Text PDFObjective: To assess the preemptive analgesia effect of catgut implantation in Chengshan (BL 57) area on hemorrhoid operation-induced pain and the security, so as to find a new method for easing post-operative pain of hemorrhoid.
Methods: A total of 120 cases of mixed hemorrhoids patients were randomly divided into the catgut implantation group and medication group (n=60). In implantation group, a piece of catgut was embedded into bilateral BL 57 acupoint area half an hour before surgery.
Objective: To discuss the effect of electroacupuncture at Chengshan (BL 57) on postoperative pain of mixed hemorrhoids.
Methods: One hundred and twenty cases with postoperative pain of mixed hemorrhoids were divided into an electroacupuncture group (60 cases) and a medication group (60 cases) randomly. The disperse-dense wave in frequency of 2Hz/100Hz at Chengshan (BL 57) were used in the electroacupuncture group.