Background: Neutrophil extracellular trap (NET) correlate with chronic obstructive pulmonary disease (COPD) severity. Platelets can promote NET generation. However, serotonin alone or serotonin-deficient platelets do not adequately promote NET production.
View Article and Find Full Text PDFObjective: The study was conducted to investigate the appropriate substitution level of soybean meal (SBM) for determining its net energy (NE), and establish NE prediction equation of SBM based on the determined NE values for pregnant sows.
Methods: In Exp. 1, eighteen pregnant sows (Landrace×Yorkshire; parity, 2 to 3) with an initial body weight (BW) of 221.
Genomic instability and inflammation are distinct hallmarks of aging, but the connection between them is poorly understood. Here we report a mechanism directly linking genomic instability and inflammation in senescent cells through a mitochondria-regulated molecular circuit involving p53 and cytoplasmic chromatin fragments (CCF) that are enriched for DNA damage signaling marker γH2A.X.
View Article and Find Full Text PDFWhile medication intake is common among pregnant women, medication safety remains underexplored, leading to unclear guidance for patients and healthcare professionals. PregMedNet addresses this gap by providing a multifaceted maternal medication safety framework based on systematic analysis of 1.19 million mother-baby dyads from U.
View Article and Find Full Text PDFA multi-function fluorescent probe HT was synthesized from 2,4-dihydroxybenzaldehyde and 6-methoxy-2-naphthaldehyde. HT demonstrated a remarkable turn on response to detect Zn in ethanol solution with strong anti-interference ability. Additionally, HT exhibited exceptional proficiency in discerning minute traces of water present in conventional organic solvents.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
May 2025
In this study, a new versatile fluorescent probe, YH (N, N-((1E, 1'E)-((phenylazanediyl)bis(4, 1-phenylene))bis(methanylylidene))di(picolinohydrazide)), was created and synthesized. YH demonstrated the capability to continuously detect Cu and PO in EtOH/HEPES solutions (95/5, V/V, HEPES = 10 mmol, pH = 7.4).
View Article and Find Full Text PDFBackground: The forkhead box A (FOXA) family has been extensively studied in cancer research; however, the role of FOXA3 in malignant tumors, particularly esophageal squamous cell carcinoma (ESCC), is not well understood. This study explores the expression and function of FOXA3 in ESCC, assessing its potential as a prognostic marker and therapeutic target.
Methods: This study analyzed FOXA3 expression in ESCC tissues and its correlation with patient prognosis.
Reactive oxygen species (ROS) play a pivotal role in maintaining tissue homeostasis, yet their overabundance can impair normal cellular functions, induce cell death, and potentially lead to neurodegenerative disorders. This study identifies Drosophila Glycoprotein 93 (Gp93) as a crucial factor that safeguards tissue homeostasis and preserves normal neuronal functions by preventing ROS-induced, JNK-dependent apoptotic cell death. Firstly, loss of Gp93 induces JNK-dependent apoptosis primarily through the induction of ROS.
View Article and Find Full Text PDFBackground: Preclinical evidence suggests that young plasma has beneficial effects on multiple organ systems in aged mice. Whether young plasma exerts beneficial effects in an aging human population remains highly controversial. Despite lacking data, young donor plasma infusions have been promoted for age-related conditions.
View Article and Find Full Text PDFUsing residual soil from the Shanghecun landslide in the western Henan Province, shear creep tests of residual soil samples with different rock contents (RCs) were performed to explore the creep characteristics, creep rate, and long-term strength of the residual soil. The test results indicate that the residual soil samples with different RCs display typical creep characteristics. With increasing RC, both the instantaneous deformation and the total creep deformation of the residual soil gradually decrease.
View Article and Find Full Text PDFThe Hippo pathway represents a highly conserved evolutionary pathway, dysfunction of which has been implicated in various diseases. RNA-binding proteins (RBPs) intricately modulate gene expression through interacting with non-coding RNAs or other proteins. To data, while an array of RBPs have been identified as modulators of the Hippo pathway, there remains a notable absence of a comprehensive review addressing the mechanistic regulations of RBPs in the transduction of Hippo signaling.
View Article and Find Full Text PDFArch Sex Behav
January 2025
Jealousy responses to potential mating rivals are stronger when those rivals display cues indicating higher mate quality. One such cue is vocal femininity in women's voices, with higher-pitched voices eliciting greater jealousy responses. However, cues to mate quality are not evaluated in isolation.
View Article and Find Full Text PDFObjective: To retrospectively analyze the incidence of infections in elderly acute myeloid leukemia (AML) patients undergoing induction therapy with venetoclax combined with hypomethylating agents and to compare these findings with those from patients receiving standard or low-dose chemotherapy.
Methods: Medical records of 169 elderly (≥60 years old) AML patients diagnosed via MICM (morphology, immunology, cytogenetics, and molecular genetics) at the First Affiliated Hospital of USTC between June 2019 and June 2022 were reviewed. Patients were divided into three groups: venetoclax combined with hypomethylating agents group (targeted therapy group), standard chemotherapy group, and low-dose chemotherapy group.
Background: Neuropathic pain resulting from spinal cord injury (SCI) is associated with persistent hyperactivity of primary nociceptors. Anandamide (AEA) has been reported to modulate neuronal excitability and synaptic transmission through activation of cannabinoid type-1 receptors (CB1Rs) and transient receptor potential vanilloid 1 (TRPV1). However, the role of AEA and these receptors in the hyperactivity of nociceptors after SCI remains unclear.
View Article and Find Full Text PDFAlzheimer's disease (AD) stands as one of the most prevalent neurodegenerative disorders, characterized by a progressive decline in cognitive function, neuroinflammation, amyloid-beta (Aβ) plaques, and neurofibrillary tangles (NFTs). With the global aging population, the incidence of AD continues to rise, yet current therapeutic strategies remain limited in their ability to significantly alleviate cognitive impairments. Therefore, a deeper understanding of the molecular mechanisms underlying AD is imperative for the development of more effective treatments.
View Article and Find Full Text PDFA novel coumarin-based fluorescent probe LY was designed and synthesized in this work. LY could selectively recognize Cu via fluorescence quenching at 522 nm in a DMSO/HO solution. The recognition process experienced minimal interference from other common cations.
View Article and Find Full Text PDFMolecules in immune cells plays a vital role in the pathogenesis of ischemic stroke (IS). The aim of this study is to profile the landscape of molecules on the basis of immune cells in IS peripheral blood and construct an immunoregulatory competing endogenous RNA (ceRNA) network. We collected and combined multiple public transcriptome datasets from the peripheral blood of IS patients and healthy controls.
View Article and Find Full Text PDFSenescent cells drive tissue dysfunction through the senescence-associated secretory phenotype (SASP). We uncovered a central role for mitochondria in the epigenetic regulation of the SASP, where mitochondrial-derived metabolites, specifically citrate and acetyl-CoA, fuel histone acetylation at SASP gene loci, promoting their expression. We identified the mitochondrial citrate carrier (SLC25A1) and ATP-citrate lyase (ACLY) as critical for this process.
View Article and Find Full Text PDFBackground: This study aims to investigate centrosomal protein 70 (CEP70) in prostate cancer and its effects on angiogenesis and tumour metastasis and elucidate its molecular mechanisms.
Methods: We evaluated CEP70 and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) in tissue samples from patients with prostate cancer by immunohistochemistry. experiments included overexpressing CEP70 through transfection and assessing its impact on human umbilical vein endothelial cells (HUVECs).
Background: Autophagy is a conserved cellular process crucial for recycling cytoplasmic components and maintaining cellular homeostasis in eukaryotes. During autophagy, the formation of a protein complex involving AUTOPHAGY-RELATED PROTEIN 6 (ATG6) and phosphatidylinositol 3-kinase is pivotal for recruiting proteins involved in phagophore expansion. However, the intricate molecular mechanism regulating this protein complex in plants remains elusive.
View Article and Find Full Text PDFThin and muscular have been characterised as body shape ideals for women and men, respectively, yet each sex misperceives what the other sex desires; women exaggerate the thinness that men like and men exaggerate the muscularity that women like. Body shape ideals align with stereotypic perceptions of femininity in women and masculinity in men. The present study investigates whether misperception of opposite-sex desires extends to femininity/masculinity in facial morphology.
View Article and Find Full Text PDFBiochim Biophys Acta Rev Cancer
November 2024
Esophageal cancer is a significant contributor to cancer-related mortality, and its poor prognosis is primarily attributed to the aggressive nature of the tumor and challenges in early detection. Currently, there are no ideal drugs developed for treatment, making it crucial to explore potential biomarkers and molecular targets for esophageal cancer. FOXP3, as a transcription factor and major regulator of regulatory T cells, not only plays a role in promoting or inhibiting tumor development in various types of cancer cells including esophageal cancer cells but also influences the function of Treg cells by regulating the expression of multiple genes.
View Article and Find Full Text PDFMetabolic reprogramming is a common feature in tumor progression and metastasis. Like proteins, lipids can transduce signals through lipid-protein interactions. During tumor initiation and metastasis, dysregulation of the Hippo pathway plays a critical role.
View Article and Find Full Text PDF