Single-Cell Multiomics Reveals TCR Clonotype-Specific Phenotype and Stemness Heterogeneity of T-ALL Cells.

T-cell acute lymphoblastic leukaemia (T-ALL) is a heterogeneous malignant disease with high relapse and mortality rates. To characterise the multiomics features of T-ALL, we conducted integrative analyses using single-cell RNA, TCR and chromatin accessibility sequencing on pre- and post-treatment peripheral blood and bone marrow samples of the same patients. We found that there is transcriptional rewiring of gene regulatory networks in T-ALL cells.

Clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease.

Background: Vertebral augmentation is the preferred treatment for Kümmell disease (KD), but there exists a risk of cement displacement resulting in severe back pain and exacerbation of kyphosis. The study aimed to investigate the efficacy and safety of a novel hollow pedicle screw combined with kyphoplasty (HPS-KP) for treating KD, effectively preventing postoperative bone cement displacement.

Methods: The prospective study included 50 KD patients with no neurological deficit detected during clinical and radiological evaluation who underwent HPS-KP ( = 25) and PKP ( = 25) surgeries.

Two-dimensional Cu-phenylalanine nanoflakes for efficient and robust CO electroreduction to C products.

The electrocatalytic reduction of CO to multicarbon (C) products is of great importance but still faces challenges. The moderate oxidation state of Cu (Cu) plays a critical role in promoting the C-C coupling, thereby enhancing the Faraday efficiency (FE) for C products. However, Cu active species are unstable during the reaction.

Safety and efficacy of adjuvant FOLFOX/FOLFIRI with versus without hepatic arterial infusion of floxuridine in patients following colorectal cancer liver metastasectomy (HARVEST trial): A randomized controlled trial.

Background: Hepatic artery infusion (HAI) chemotherapy, particularly with floxuridine (FUDR), has previously shown effectiveness in improving recurrence-free survival (RFS) in colorectal cancer (CRC) patients with colorectal liver metastases (CRLM). Nonetheless, its adjuvant use alongside modern systemic chemotherapy remains unevaluated.

Patients And Methods: The HARVEST trial is an open-label, randomized, controlled study conducted from May 2018 to August 2021.

Early dFLC response by C1D7 predicts complete hematologic response in systemic AL amyloidosis.

Daratumumab and bortezomib, the first-line drugs for AL amyloidosis, typically yield a complete hematologic response (CHR) rate of nearly 60% when used in combinations. An early achievement of CHR is crucial in amyloidosis. We retrospectively evaluated the relationship between dFLC (the difference between free light chain) reduction by Day 7 in Cycle 1 (C1D7) and CHR, organ response, and survival in 48 newly diagnosed AL amyloidosis patients receiving daratumumab, bortezomib, and dexamethasone.

FDM 3D Printing and Properties of WF/PBAT/PLA Composites.

Fused deposition molding (FDM) is a commonly used 3D printing method, and polylactic acid (PLA) has become one of the most important raw materials for this technology due to its excellent warping resistance. However, its mechanical properties are insufficient. Polybutylene adipate terephthalate (PBAT) is characterized by high toughness and low rigidity, which can complement the performance of PLA.

Enhanced performance of flexible BiFeO ferroelectric memory with Mica substrate via SrTiO buffer layer.

BiFeO (BFO) application in flexible wearable devices is garnering interest because of its unique ferroelectric and magnetic properties. However, the integration of high-quality BFO films onto flexible substrates presents significant technical challenges. Here, we successfully fabricated high-quality BFO films on mica substrates by using pulsed laser deposition, and report the fatigue characteristics of BFO films on flexible substrates for the first time.

Design and Fabrication of a C-Band Patch Antenna with Low Loss BaMSiO Microwave Dielectric Ceramics.

Single-phase BaMSiO (M = Yb, Er, Y, Ho) ceramics have been investigated for their crystal structures, microwave dielectric properties, flexural strength, and potential applications in dielectric antennas. Rietveld refinement and TEM analysis revealed that the BaMSiO ceramics exhibit a monoclinic structure (space groups: 2/). The ε of the BaMSiO ceramics was dominated by ionic polarizability and ρ.

Stabilizing the Layer-Structured Oxide Cathode by Modulating the Oxygen Redox Activity for Sodium Ion Batteries.

The layer-structured oxide cathode for sodium-ion batteries has attracted a widespread attention due to the unique redox properties and the anionic redox activity providing additional capacity. Nevertheless, such excessive oxygen redox reactions will lead to irreversible oxygen release, resulting in a rapid deterioration of the cycling stability. Herein, sulfur ion is successfully introduced to the O3-NaNiMnCuTiWO material through high-temperature quenching, thereby developing a novel NaS-modified O3/P2-NaNiMnCuTiWO composite with extended cycling life.

Enhanced Magnetic Heating for Efficient Oxygen Evolution Reaction by Pinning Effect of Ferromagnetic/Antiferromagnetic Coupling.

The magnetic heating effect under alternating magnetic fields (AMFs) has recently gained attention in catalysis due to its potential to greatly boost catalytic activities by providing localized heating around magnetic nanoparticles. However, nanoparticles still suffer from low magnetic heating efficiency due to their low magnetic anisotropy and thermal fluctuation, which is a key barrier in the wide application of AMF-assisted catalysis. Herein, by introducing the pinning effect of ferromagnetic/antiferromagnetic (FM/AFM) coupling, NiO/NiOOH (AFM/FM) core-shell nanoparticles exhibit significantly enhanced oxygen evolution reaction activity and resistance to thermal fluctuations under AMF, compared to NiOOH nanoparticles.

Effectiveness of indomethacin in preventing Heterotopic Ossification: a systematic review and meta-analysis of randomized controlled trials.

Background: Heterotopic ossification (HO) is a frequent complication of joint trauma or surgery, commonly occurring after hip replacements, acetabular or other joint injuries, or surgeries. Indomethacin has long been used to prevent HO and is considered the first-line therapy. However, its effectiveness and necessity for HO prevention are still debated due to mixed evidence about its efficacy and potential side effects.

Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics.

There are only eight approved small molecule antiviral drugs for treating COVID-19. Among them, four are nucleotide analogues (remdesivir, JT001, molnupiravir, and azvudine), while the other four are protease inhibitors (nirmatrelvir, ensitrelvir, leritrelvir, and simnotrelvir-ritonavir). Antiviral resistance, unfavourable drug‒drug interaction, and toxicity have been reported in previous studies.

Enhanced pH-sensitive anthocyanin film based on chitosan quaternary ammonium salt: A promising colorimetric indicator for visual pork freshness monitoring.

An intelligent pH response indicator film is an easy-to-use device for the real-time monitoring of meat freshness during transport and storage. Therefore, a novel pH-sensitive anthocyanin indicator film composed of polyvinyl alcohol-blueberry anthocyanin (BA)-2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC) called PAH-2.0 with 1.

Expression profiles and functional analysis of transfer RNA-derived small RNAs (tsRNAs) in photoaged human dermal fibroblasts.

Transfer RNA-derived small RNAs (tsRNAs) refer to a newly established family of non-coding RNAs that regulate a diverse set of biological processes. However, the function of tsRNAs in skin photoaging remains unclear. This research aims to investigate the potential correlation between tsRNAs and skin photoaging.

Growth of HgCdTe on Van Der Waals Mica Substrates via Molecular Beam Epitaxy.

In this paper, we present a study on the direct growth of Hg0.7Cd0.3Te thin films on layered transparent van der Waals mica (001) substrates through weak interface interaction through molecular beam epitaxy.

A study of the influence of the stability of the population's income and expenditure on the development of restaurant chains.

This study examines the connection between the income of Chinese residents and the expansion of restaurant chains from 2005 to 2021. It employs multiple methodologies, such as an evaluation index system, the entropy value method, and the coupled coordination degree model. There are sixteen indicators divided into two groups: residents' income and expenditures, and restaurant chain expansion.

Genome mining of WOX-ARF gene linkage in underpinned cambial activity associated with IAA induction.

As an upright tree with multifunctional economic application, is an excellent choice in modern forestry from Lauraceae. The growth characteristics is of great significance for its molecular breeding and improvement. However, there still lack the information of WUSCHEL-related homeobox () and Auxin response factor () gene family, which were reported as specific transcription factors in plant growth as well as auxin signaling.

Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction.

Adult neurogenesis in the subventricular zone (SVZ) is essential for maintaining neural homeostasis, and its dysregulation contributes to anosmia and delayed tissue healing in neurological disorders, such as Parkinson's disease (PD). Despite intricate regulatory networks identified in SVZ neurogenesis, the molecular mechanisms dynamically maintaining neural stem/progenitor cells (NSPCs) in response to physiological and pathological stimuli remain incompletely elucidated. We generated an RNA binding motif protein 24 (Rbm24) knockout model to investigate its impact on adult neurogenesis in the SVZ, employing immunofluorescence, immunoblot, electrophysiology, RNA-sequencing, and experiments.