Effects of a comprehensive program on reducing cancer-related fatigue: A randomized controlled trial.

Context: Cancer-related fatigue (CRF) can affect patients undergoing chemotherapy severely. A comprehensive intervention targeted for reducing CRF is lacking.

Objectives: To evaluate the effectiveness of an innovative multi-faceted web-based patient-empowered CRF management program for improving CRF, perceived self-efficacy for fatigue self-management (PSEFSM), physical activity, quality of sleep, anxiety, depression, pain and quality of life (QoL) among gastric cancer patients undergoing chemotherapy in China.

Vagal response during radiofrequency catheter ablation initiated from right superior pulmonary vein: Incidence, risk factors, and clinical outcomes.

Background: The vagal response (VR) is unavoidable during pulmonary vein isolation (PVI) for atrial fibrillation (AF). In this study, we aimed to investigate the incidence, risk factors, and clinical outcomes of VR during PVI initiated from the right superior pulmonary vein (RSPV).

Methods: Patients with AF were consecutively enrolled.

Tough and Functional Hydrogel Coating by Electrostatic Spraying.

Hydrogel coatings impart superior surface properties to materials, but their application on large and complicated substrates is hindered by two challenges: limited wetting conditions and intricate curing processes. To overcome the challenges, lyophilized adhesive hydrogel powders (LAHPs) are developed, which consist of poly(acrylic acid-co-3-(trimethoxysilyl)propyl methacrylate) crosslinked with chitosan. These powders are electrostatic sprayed onto substrates to address wetting issues and rehydrated to form bulk hydrogel coatings to circumvent curing challenges.

Role of TgVIN1 and TgPEPCK in sugar/starch and lipid metabolism pathways in Torreya grandis seeds under foliar fertilizer treatments.

Foliar fertilizers quickly replenish nutrients for plant growth, boosting production and quality. However, how this affects metabolite accumulation in fruits is unclear. In this study, the metabolome and transcriptome of Torreya grandis seeds were investigated after five different foliar fertilizer treatments.

D-aring to explore: New approaches to gasdermin D targeting.

Novel inhibitors of pyroptosis promise breakthroughs in treating inflammatory diseases and malignant tumors. In this issue of Cell Chemical Biology, Hu et al. identify two repurposed drugs that selectively target gasdermin D (GSDMD) oligomers, effectively suppressing pyroptosis while reducing off-target effects typical of cysteine-based inhibitors.

Rhamnolipid Modified Silica Nanoparticles Control Rice Blast Disease by Enhancing Antifungal Activity and Antioxidant Defense System of Rice ( L.).

Blast disease caused by is a devastating disease that limits rice grain production. Here, we synthesized rhamnolipid (RL) modified silica nanoparticles (SiONPs) based on the excellent antimicrobial activity of RL against various phytopathogens and the role of SiONPs in alleviating plant diseases and investigated the roles and mechanisms of RL@SiONPs application in controlling rice blast disease. Two-week-old rice seedlings were sprayed with 100 mL/L of different materials before pathogen inoculation, and blast incidence was investigated 5 days after inoculation.

Catalytic degradation of Rhodamine B through peroxymonosulfate activation by the Co-doped hydroxyapatite.

Supported Co-based catalysts have shown attractive prospects for peroxymonosulfate (PMS) activation. In this work, Co-doped hydroxyapatite (H-Co/HAP) composites were prepared by a simple hydrothermal method. The Co content in H-Co/HAP could reach 71.

Analysis of synthetic polymer hydrogel-based generation of leukemia stem cells.

Leukemia stem cells (LSCs), capable of simultaneous self-renewal and differentiation, are resistant to chemotherapy and the cause of relapse in refractory cases of leukemia. As a method to rapidly generate LSCs has not been established, research on LSCs as therapeutic targets has been hampered. Here, we demonstrate that K562 leukemia cells acquired LSC properties with increase in stemness markers such as CD34, Oct3/4, and Nanog and metabolic alterations towards OXPHOS by culturing cells on synthetic polymer hydrogels.

A protocol for high-throughput screening for small chemicals promoting macrophage-mediated tumor cell phagocytosis in mice.

Macrophage-mediated phagocytosis has emerged as a pivotal mechanism for eliminating tumor cells within the realm of cancer immunotherapy. Here, we present a protocol for identifying small molecules that enhance phagocytosis in mice using a co-culture system comprising primary macrophages, cancer cells, and a blockade of phagocytic checkpoints. We describe steps for expressing enhanced green fluorescent protein-luciferase (eGFP-Luc) and producing bone marrow-derived macrophages (BMDMs).

Exploring the value of multiparametric quantitative MRI in the assessment of pancreatic ductal adenocarcinoma fibrosis grading.

Objectives: To analyze the performance of multiparametric magnetic resonance imaging (MRI) in quantification of pancreatic ductal adenocarcinoma (PDAC) fibrosis grading.

Method: This prospective study enrolled 79 patients with PDAC confirmed by pathology. Multiparametric MRI including native T1 mapping, intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), diffusion kurtosis imaging diffusion-weighted imaging (DKI-DWI), and enhanced T1 mapping were performed before surgery.

Lycopene's therapeutic mechanisms in epididymitis: a network pharmacology and experimental study.

Background: Epididymitis, a common disease of the male reproductive system, is often caused by nonspecific infections. Antibiotics alone cannot reverse histopathological changes or prevent long-term reproductive issues. Lycopene (LYC), a potent antioxidant, has shown potential in alleviating epididymitis, yet its specific mechanisms remain unclear.

Neuroepithelial cell transforming 1 as a key regulator in non-small cell lung cancer: unveiling causal links and therapeutic potentials.

Background: High incidence and mortality rates underscore lung cancer as a significant global health issue. Understanding the molecular mechanisms driving its progression is crucial for developing effective treatments. This study explores a potential molecular regulator that may contribute to the progression of non-small cell lung cancer (NSCLC) by utilizing bioinformatics analyses and laboratory experiments, aiming to provide insights that could inform future therapeutic strategies.

Palladium-Catalyzed Domino Carboetherification Reactions: Synthesis of Bis-Heterocycles Bearing Isoxazoline and Methyleneindole Motifs.

A novel and highly efficient Pd-catalyzed approach for the synthesis of bis-heterocycles featuring both isoxazoline and methyleneindole motifs is demonstrated. The in situ formation of vinyl Pd(II) species through an alkyne-tethered carbamoyl chloride cyclization is crucial, and the innovative Pd-catalyzed carboetherification of β,γ-unsaturated oximes with vinyl Pd(II) species has been developed. This method is not only operationally straightforward but also exhibits a broad substrate scope and excellent functional group tolerance.

[Analysis of clinical features of ruccrent interstitial lung disease in patients with anti-EJ positive antisynthetase syndrome].

Objective: To summarize the clinical characteristics of 57 patients diagnosed with anti-glycyl tRNA synthetase (anti-EJ) positive antisynthetase syndrome (ASS), a subtype of anti-glycyl tRNA positive ASS, complicated by interstitial lung disease (ILD), and to investigate the factors asso-ciated with ILD recurrence.

Methods: A retrospective analysis was conducted on the clinical data of 57 anti-EJ positive ASS patientswho were treated at the First Affiliated Hospital of Nanjing Medical University from January 1, 2020 to June 30, 2024. The data collected included demographic information, clinical characteristics, laboratory test results, chest CT findings, and pulmonary function tests.

Is Semiconducting Transition-Metal Dichalcogenide Suitable for Spin Pumping?

Spin pumping has been reported on interfaces formed with ferromagnetic metals and layered transition-metal dichalcogenides (TMDs), as signified by enhanced Gilbert damping parameters extracted from magnetodynamics measurements. However, whether the observed damping enhancement purely arises from the pumping effect has remained debatable, given that possible extrinsic disturbances on the interfaces cannot be excluded in most of the experiments. Here, we explore an atomically clean interface formed with CoFeB and atomically thin MoSe, achieved by an all growth strategy based on molecular beam epitaxy.

Hither-CMI: Prediction of circRNA-miRNA Interactions Based on a Hybrid Multimodal Network and Higher-Order Neighborhood Information via a Graph Convolutional Network.

Numerous studies show that circular RNA (circRNA) functions as a sponge for microRNA (miRNA), significantly regulating gene expression by interacting with miRNA, which in turn affects the progression of human diseases. Traditional experimental approaches for investigating circRNA-miRNA interactions (CMI) are both time-consuming and costly, making computational methods a valuable alternative. Hence, we propose a computational model for predicting CMI, leveraging a ybrid multmodal nework and igher-order nighborhood infomation (Hither-CMI).

Conversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acids: bioavailability and dietary regulation.

N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are essential for physiological requirements and disease prevention throughout life but are not adequately consumed worldwide. Dietary supplementation with plant-derived α-linolenic acid (ALA) has the potential to rebalance the fatty acid profile and enhance health benefits but faces challenges such as high β-oxidation consumption, low hepatic conversion efficiency, and high oxidative susceptibility under stress. This review focuses on the metabolic fate and potential regulatory targets of ALA-containing lipids , specifically the pathway from the gastrointestinal tract to the lymph, blood circulation, and liver.

Modeling and Simulation of Eddy Current Dissipation Magnetic Acceleration Noise of Space Inertial Sensors.

The magnetic acceleration noise (MAN) that stems from the eddy current dissipation of a test mass (TM) serves as an important source of noise for space inertial sensors. Given the problem that the eddy current dissipation magnetic acceleration noise (ECDMAN) of a cubic TM defies analytical solutions, an analytical model of ECDMAN for a spherical TM, which has the same volume as the cubic TM, is systematically derived on the basis of the principles of electromagnetism and the fluctuation-dissipation theorem, and this model can be used as an approximate analytical model for the evaluation of this noise term. Based on the approximate analytical model, with the TM of the LISA Pathfinder (LPF) as the research object, this paper obtains a modification coefficient using the approach of combining the analytical method with the finite element method (FEM), and establishes a semi-analytical model of ECDMAN for the cubic TM.

An Oriented Recrystallization Nucleation Mechanism of a Cold-Rolled Pure Ti with Electric-Pulse Treatment.

The effect of electric-pulse treatment (EPT) on the nucleation behavior of a cold-rolled pure Ti was investigated. The specimens are subjected to EPT and then annealed at 650 °C within 10 min. Both the electron backscatter diffraction (EBSD) and transmission electron microscope (TEM) techniques were used for detailing the microstructural evolution of the specimens at the initial stage of recrystallization processing during annealing.

Structure-Based Screening and Optimization of PafA Inhibitors with Potent Anti-Tuberculosis Activity.

Tuberculosis (TB), caused by (), remains a major global health challenge, primarily due to the increasing prevalence of drug resistance. Consequently, the development of drugs with novel modes of action (MOAs) is urgently required. In this study, we discovered and characterized two potent inhibitors, Pi-1-58 and Pi-2-26, targeting the prokaryotic ubiquitin-like protein (Pup) ligase PafA of .

Advances in Molecular Dynamics-Based Characterization of Water and Ion Adsorption and Transport in C-S-H Gels.

Cementitious material durability is affected by the transport and adsorption of water molecules and ions in the nanopore channels of cement hydration products. Hydrated calcium silicate (C-S-H) accounts for about 70% of the hydration product. It determines the mechanical properties of cementitious materials and their internal transport properties.

Straw Returning Methods Affects Macro-Aggregate Content and Organic Matter Content in Black Soils: Meta-Analysis and Comprehensive Validation.

Straw returning into the soil is a crucial method for boosting soil carbon levels. To research the influence of straw return practices on soil aggregates and organic matter content within the farmlands of the Northeast Black Soil Region, the objective was to clarify the varying impacts of these practices on soil carbon enhancement. In this study, 89 pertinent papers were acquired through a rigorous literature compilation.

Transcutaneous Auricular Vagus Nerve Stimulation for Chronic Insomnia Disorder: A Randomized Clinical Trial.

Importance: Evidence from randomized clinical trials of transcutaneous auricular vagus nerve stimulation (taVNS) for chronic insomnia disorder is lacking.

Objective: To evaluate the efficacy and safety of taVNS for chronic insomnia compared with the sham taVNS.

Design, Setting, And Participants: This randomized clinical trial was conducted from October 2021 to December 2022 at a single center in Beijing, China.

Case report: A case of giant malignant solitary fibrous tumor of the pleura with Doege-Potter's syndrome and review of the literature.

The solitary fibrous tumor of the pleura (SFTP) is a rare intrathoracic neoplasm that commonly originates from the subpleural mesenchymal cells of the visceral pleura and accounts for less than 5% of all pleural tumors. We reported a case of a 54-year-old man with a two-week history of hypoglycemia, a six-month history of productive cough and fatigue, and chronic right chest pain. Radiological techniques revealed a giant intra-thoracic mass with hypervascularization, and pathological staining was carried out to make a definitive diagnosis of SFTP.