Modeling monocular form deprivation in rabbits using a simulated-cataract intraocular lens.

Aim: To establish an animal model of form deprivation amblyopia based on a simulated cataract intraocular lens (IOLs).

Methods: Poly(dimethyl siloxane)-SiO thin films (PSF) with different degrees of opacity as IOL materials were prepared. The light transmission of the PSF-IOL was measured, and its biosafety was determined by cell counting kit (CCK)-8 assay using the HLEC-B3 cell line and ARPE-19 cell line.

Small RNA sequencing data of plasma extracellular vesicles in a breast cancer screening population.

The pathogenesis of breast cancer is still unclear. Small RNAs associated with extracellular vesicles (EVs) have been found to be involved in tumor development. It is important to explore the role of EVs small RNAs in breast cancer.

Neutrophil-to-lymphocyte ratio combined with albumin to globulin ratio for predicting rheumatoid arthritis-associated pneumonia.

Objective: Rheumatoid arthritis-associated pneumonia (RAP) is a common complication of rheumatoid arthritis (RA) and is related to poor prognosis. Inflammation plays an important role in the development of RAP. This study aims to analyze and explore the predictive value of the neutrophil/lymphocyte ratio (NLR) combined with the albumin to globulin ratio (AGR) for assessing RAP.

Zero-Dimensional Lead-Free Perovskite Single Crystals for the Sensitive Detection of Visible Light and X-Rays.

The excellent performance and facile fabrication process of perovskite semiconductor materials make them highly promising candidates in the field of optoelectronic devices. Whether for visible light or X-rays, detectors with low detection limits can better identify weak light signals, significantly reducing the intensity of the received light source during device operation. In particular, for X-ray detectors, reducing X-ray dosage can greatly enhance the safety of X-ray imaging technology.

Rotenone adaptation promotes migration and invasion of p53-wild-type colon cancer through lipid metabolism.

Background: The association between mitochondrial dysfunction and multiple metabolic adaptations is increasingly being proven. We previously elucidated that mitochondrial complex I deficiency can promote glycolysis in mut-p53 SW480 cells. However, studies have revealed a phenotype with attenuated glycolysis but enhanced fatty acid oxidation (FAO) in invasive tumors.

The Altered Lipid Composition and Key Lipid Metabolic Enzymes in Thiacloprid-Resistant , with Special Attention Paid to the Function of .

Neonicotinoid resistance is increasingly prevalent in the agricultural pest . Lipids play a critical role in insect defense systems, but their contribution to insect neonicotinoid resistance is disregarded. We conducted metabolomics and transcriptomics studies on thiacloprid-resistant (THG-R) and -susceptible (FFJ-S) populations.

Heat stress regulates the migration and proliferation of lens epithelial cells through ferroptosis and NCOA4-FTH1 interaction.

Posterior capsule opacification (PCO) due to the proliferation and migration of lens epithelial cells (LECs) is the main complication after surgery. Heat stress has demonstrated impressive results in halting cell proliferation and migration, while also facilitating cell death. This study aimed to investigate the role and mechanism of ferroptosis in the proliferation and migration of LECs under heat stress.

Predicting straw drinking ability of liquid foods by pipe-flow rheometry.

Designing the straw drinking experience is increasingly important in consumer-oriented liquid food innovation. The perceived 'straw drinking ease' of liquid foods could be assessed by sensory analysis. However, challenges arise in linking instrumental measurements to the subjective quantification of sensory attributes due to the complexity of perceptual behaviors in drinking.

Turnover intention among healthcare workers in Shenzhen, China: the mediating effect of job satisfaction and work engagement.

Background: To ensure workforce stability in China's healthcare system and maintain high-quality care, it is essential to comprehensively understand the interplay of factors contributing to turnover intention of healthcare workers. This study aims to examine the associations between potential factors and turnover intention in healthcare workers and explore the mediating effect of job satisfaction and work engagement in the association between them.

Methods: In this cross-sectional study, a random sample of 1060 healthcare workers working in 98 public medical institutions were recruited to rate their turnover intention in 2018 in Shenzhen, China.

Can digital technology adoption promote environmental innovation in small and medium-sized enterprises (SMEs)? Evidence from China.

Despite the widespread acknowledgment in both industry and academia of the substantial potential of digital technology for fostering innovation and sustainable development, there remains uncertainty surrounding whether integrating these technologies can improve environmental innovation in small and medium-sized enterprises (SMEs) due to the liability of smallness. This paper utilizes a panel dataset comprising 1036 Chinese manufacturing SMEs listed between 2011 and 2020 to investigate the influence of different digital technology adoption strategies-specifically, digital technology adoption breadth (DTAB) and digital technology adoption depth (DTAD)-on SMEs' environmental innovation. Additionally, we examine the moderating effects of government subsidies and industrial agglomeration on these relationships.

Survival Outcomes of Neoadjuvant Therapy Followed by Sleeve Lobectomy in Non-Small Cell Lung Cancer.

Background: This study was carried out to evaluate the impact of neoadjuvant therapy on long-term survival of patients with non-small cell lung cancer undergoing sleeve lobectomy.

Methods: A total of 613 patients were retrospectively analyzed, including 124 who received neoadjuvant therapy. A 1:2 propensity score matching method was adopted to create a balanced cohort including 110 with neoadjuvant therapy and 169 without neoadjuvant therapy.

Subxiphoid Uniportal Robotic Assisted Right Upper Lobectomy in Swine: A Novel Technology.

Background: Uniportal video assisted thoracoscopic surgery has become widely accepted with increasing subxiphoid approach for major pulmonary resections. The purpose of this study was to verify the safety and feasibility of a SHURUI single port (SP) Robotic Surgical System in subxiphoid right upper lobectomy.

Methods: Five swine models were used to perform subxiphoid right upper lobectomy with SHURUI SP Robotic Surgical System.

Caveolin 1 ameliorates nonesterified fatty acid-induced oxidative stress via the autophagy regulator Beclin 1 in bovine mammary gland epithelial cells.

High blood concentrations of nonesterified fatty acids (NEFA) during ketosis enhance uptake by the mammary gland and impair autophagy while causing oxidative stress. Caveolin 1 (CAV1) is closely related to autophagy and plays a role in regulating oxidative stress. The aim of this study was to explore the potential role of CAV1 on oxidative stress and autophagy during a high NEFA challenge in the immortalized bovine mammary epithelial cell line MAC-T.

High sensitivity and selectivity of h-BN/WO n-n heterojunction to triethylamine at low-temperature.

Due to the unique properties of heterojunction interfaces, heterojunction materials have broad application prospects in gas sensors. In this work, a facile and economical two-step synthesis method was employed to fabricate h-BN/WO heterojunctions, exhibiting excellent performance in triethylamine (TEA) detection. The results indicate that compared to pure WO sensors, h-BN/WO sensors exhibit superior TEA sensing capabilities, with an excellent response of 281.

Oleogels loaded with lycopene structured using Zein/EGCG/Ca complexes: Preparation, characterization and potential application.

Oleogels have attracted considerable attention due to their excellent viscoelasticity and high content of polyunsaturated fatty acid. This study explored the potential of Zein/(-)-epigallocatechin-3-gallate/Ca complexes oleogels loaded with lycopene as potential substitute for solid fats in biscuit formulations. Utilizing an emulsion-templated method, oleogels were prepared and characterized for visual appearance, droplet size, microstructure, and rheological properties.

Research Progress on the Role of M6A in Regulating Economic Traits in Livestock.

Reversible regulation of N6-methyladenosine (m6A) methylation of eukaryotic RNA via methyltransferases is an important epigenetic event affecting RNA metabolism. As such, m6A methylation plays crucial roles in regulating animal growth, development, reproduction, and disease progression. Herein, we review the latest research advancements in m6A methylation modifications and discuss regulatory aspects in the context of growth, development, and reproductive traits of livestock.

Identification of Active Molecules against Thrombocytopenia through Machine Learning.

Thrombocytopenia, which is associated with thrombopoietin (TPO) deficiency, presents very limited treatment options and can lead to life-threatening complications. Discovering new therapeutic agents against thrombocytopenia has proven to be a challenging task using traditional screening approaches. Fortunately, machine learning (ML) techniques offer a rapid avenue for exploring chemical space, thereby increasing the likelihood of uncovering new drug candidates.

Supragel-mediated efficient generation of pancreatic progenitor clusters and functional glucose-responsive islet-like clusters.

Although several synthetic hydrogels with defined stiffness have been developed to facilitate the proliferation and maintenance of human pluripotent stem cells (hPSCs), the influence of biochemical cues in lineage-specific differentiation and functional cluster formation has been rarely reported. Here, we present the application of Supragel, a supramolecular hydrogel formed by synthesized biotinylated peptides, for islet-like cluster differentiation. We observed that Supragel, with a peptide concentration of 5 mg/mL promoted spontaneous hPSCs formation into uniform clusters, which is mainly attributable to a supporting stiffness of ∼1.

Colloidal lignin particle reinforces the stability of Pickering emulsions prepared with zein nanoparticle.

Zein nanoparticle (ZNP) is at the forefront of research on Pickering emulsions, valued for its self-assembling and surfactant-free nature. Nevertheless, its emulsion stability is undermined by inadequate amphiphilicity. Colloidal lignin particle (CLP), characterized by its antithetical charge and amphiphilic nature, appears the promising for augmenting the stability of ZNP-based emulsion.