ImmunoPET Imaging of Trop2 Expression in Bladder Cancer Using [Cu]Cu-NOTA-Trodelvy.

Trop2 exhibits significantly elevated expression in numerous solid malignancies, playing a crucial role in tumor advancement, whereas its presence in healthy tissues is minimal. In this study, we investigated Trop2 expression in bladder cancer models using [Cu]Cu-NOTA-Trodelvy for immunoPET imaging. In HT-1376 models, [Cu]Cu-NOTA-Trodelvy effectively visualized tumor as early as 12 h p.

Multiple metabolic analysis of [F]FDG PET/CT in patients with kidney disease.

Purpose: This study aimed to evaluate the value of [F]FDG PET/CT in patients with kidney disease by using multiple metabolic parameters.

Materials And Methods: A retrospective review of 182 kidney disease patients and 32 controls was conducted. Patients were categorized into acute kidney disease (AKD), AKI on CKD (A/C), and chronic kidney disease (CKD) groups, further divided by CKD stage and disease etiology.

iGlarLixi provides improved early glycaemic control after 12 weeks of treatment compared with basal insulin in Asian people with type 2 diabetes: A post hoc analysis of the LixiLan-O-AP and LixiLan-L-CN studies.

Aims: To evaluate early glycaemic control (glycated haemoglobin [HbA1c] < 7.0% [<53.0 mmol/mol], fasting plasma glucose [FPG] ≤ 7.

A Review of Recent Advances in Unidirectional Ultrasonic Guided Wave Techniques for Nondestructive Testing and Evaluation.

Unidirectional ultrasonic guided waves (UGWs) play a crucial role in the nondestructive testing and evaluation (NDT&E) domains, offering unique advantages in detecting material defects, evaluating structural integrity, and improving the accuracy of thickness measurements. This review paper thoroughly studies the state of the art of unidirectional UGWs before presenting a comprehensive review of the foundational mathematical principles of unidirectional UGWs, focusing on the recent advancements in their methodologies and applications. This review introduces ultrasonic guided waves and their modes before looking at mode excitability and selectivity, signal excitation, and mechanisms used to generate and receive guided waves unidirectionally.

ImmunoPET imaging of Trop2 expression in triple-negative breast cancer using [Cu]Cu-NOTA-Trodelvy-F(ab').

Purpose: The Trop2-targeting antibody-drug conjugate (ADC) sacituzumab govitecan (Trodelvy) has demonstrated remarkable efficacy in patients with metastatic triple-negative breast cancer (TNBC). ImmunoPET imaging offers a noninvasive method to visualize the expression and distribution of target antigens in vivo. In this study, we developed F(ab') fragments of Trodelvy for immunoPET imaging to detect Trop2 expression in TNBC models, aiming to achieve a shorter imaging window.

Nonlinear Optical Effects Modulated by Distinctive Monovalent Cations with Lone Electron Pairs in AGaI (A = Ga, In).

Tetrahedral halides are promising candidates for infrared (IR) nonlinear optical (NLO) materials, exhibiting balanced properties due to their wide IR transparency, large energy bandgaps, and strong NLO effects. When containing monovalent Ga/In cations with lone-electron pairs, tetrahedral halides are not only capable of producing strong anisotropic optical effects, but also of maintaining an excellent performance balance. AGaCl (A = Ga, In) is an example of this distinctive system, although it has a narrower IR transparency range than AgGaS and tends to deliquesce.

Diagnostic and prognostic role of F-FDG PET/CT for sarcomatoid differentiation in renal cell carcinoma.

Background: Sarcomatoid differentiation is an invasive dedifferentiated feature of tumor and associated with poor prognosis in renal cell carcinoma (RCC) patients. This study aimed to evaluate the utility of F-FDG PET/CT in predicting sarcomatoid differentiation in RCC and its potential prognostic value.

Results: This retrospective study assessed newly diagnosed sarcomatoid differentiation renal cell carcinoma (SDRCC) patients who were staged using F-FDG PET/CT.

One-Dimensional Perovskite RbGeI with Large Optical Anisotropy.

Inorganic halide perovskites have been regarded as potential candidates for nonlinear optical (NLO) materials due to their large bandgaps and second-harmonic generation (SHG) effects. If these crystals exhibit large optical anisotropy, their birefringent phase-matching ability will undergo enhancement. In this study, a one-dimensional (1D) halide perovskite, RbGeI, was experimentally synthesized.

A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells.

Introduction: Allogeneic chimeric antigen receptor T (CAR-T) therapy, also known as universal CAR-T (UCAR-T) therapy, offers broad applicability, high production efficiency, and reduced costs, enabling quicker access for patients. However, clinical application remains limited by challenges such as immune rejection, and issues with potency and durability.

Methods: We first screened a safe and effective anti-CD70 scFv to construct anti-CD70 CAR-T cells.

Population profile and glycemic control following initiation or switch of injectable therapies in Tianjin, China: A real-world retrospective cohort study of adults with type 2 diabetes.

Aims: To evaluate characteristics and glycemic outcomes in individuals with type 2 diabetes using injectable therapies in real-world clinical practice in Tianjin, China.

Materials And Methods: Data from inpatients and outpatients receiving injectable therapies between January 2015 and December 2019 were collected from the Tianjin regional electronic medical records and retrospectively analyzed. Seven cohorts were identified, including individuals initiating injectable therapies (premixed insulin [n = 4,687], basal insulin [4,177], or glucagon-like peptide-1 receptor agonists [541]) or switching injectable therapies (premixed insulin to basal insulin [1,298], basal insulin to premixed insulin [1,457], basal insulin to basal + bolus insulin [1,772], or glucagon-like peptide-1 receptor agonists to basal insulin ± glucagon-like peptide-1 receptor agonists [82]).

Natural variations in and its neighboring confer yellow seed with elevated oil content in .

Seed color is a critical quality trait in numerous plant species. In oilseed crops, including rapeseed and mustard, yellow seeds are distinguished by their significantly higher oil content and faster germination rates compared to black or brown counterparts. Despite the agronomic significance of the yellow seeds being a prime breeding target, the mechanisms underlying elevated oil content remain obscure.

Preclinical evaluation of zirconium-89 labeled anti-Trop2 antibody-drug conjugate (Trodelvy) for imaging in gastric cancer and triple-negative breast cancer.

Purpose: Trophoblast cell-surface antigen 2 (Trop2) is overexpressed in various solid tumors and contributes to tumor progression, while its expression remains low in normal tissues. Trop2-targeting antibody-drug conjugate (ADC), sacituzumab govitecan-hziy (Trodelvy), has shown efficacy in targeting this antigen. Leveraging the enhanced specificity of ADCs, we conducted the first immunoPET imaging study of Trop2 expression in gastric cancer (GC) and triple-negative breast cancer (TNBC) models using Zr-labeled Trodelvy ([Zr]Zr-DFO-Trodelvy).

Systemic progression of primary cutaneous anaplastic large cell lymphoma in F-FDG PET/CT: a case report.

Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a type of skin T-cell lymphoma with a favorable prognosis. Some patients may experience recurrence, but systemic involvement is rare. Some studies suggest that systemic progression is associated with poor prognosis.

Can Low Structural Anisotropy Produce High Optical Anisotropy? Anomalous Giant Optical Birefringent Effect in PIAlI in Focus.

Tetrahedral halides with broad transparency and large second harmonic effects have the potential to serve as mid-infrared wide-bandgap materials with balanced nonlinear-optical (NLO) properties. However, their regular tetrahedral motifs tend to exhibit low optical birefringence (Δ < 0.03) due to limited structural anisotropy, which constrains their practical phase-matched capability.

CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies.

Purpose: CD38 is a glycoprotein highly specific to multiple myeloma (MM). Therapeutics using antibodies targeting CD38 have shown promising efficacy. However, the efficient stratification of patients who may benefit from daratumumab (Dara) therapy and timely monitoring of therapeutic responses remain significant clinical challenges.

Integrated analysis of BSA-seq and RNA-seq identified the candidate genes for seed weight in .

Introduction: is a major oilseed crop of . The seed weight is one of yield components in oilseed crops. Research on the genetic mechanism of seed weight is not only directly related to the yield and economic value of Brassica juncea but also can provide a theory foundation for studying other Brassica crops.

Efficacy and safety of switching to insulin glargine 300 U/mL in people with type 2 diabetes uncontrolled on basal insulin in China: A post hoc subpopulation analysis of the INITIATION study.

Aims: To evaluate the efficacy and safety of insulin glargine 300 U/mL (Gla-300) in people with uncontrolled type 2 diabetes (T2D) switching from another basal insulin (BI).

Materials And Methods: INITIATION was an interventional, single-arm, phase IV study conducted in China. In this post hoc subpopulation analysis, the efficacy and safety of switching to Gla-300 was investigated in individuals with uncontrolled T2D (HbA1c 7.

NS2B-D55E and NS2B-E65D Variations Are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model.

Japanese encephalitis virus (JEV) NS2B-NS3 is a protein complex composed of NS3 proteases and an NS2B co-factor. The N-terminal protease domain (180 residues) of NS3 (NS3(pro)) interacts directly with a central 40-amino acid hydrophilic domain of NS2B (NS2B(H)) to form an active serine protease. In this study, the recombinant NS2B(H)-NS3(pro) proteases were prepared in and used to compare the enzymatic activity between genotype I (GI) and III (GIII) NS2B-NS3 proteases.

Efficacy and safety of blinatumomab for the treatment of patients relapsing after allogeneic hematopoietic cell transplantation: a systemic review and meta-analysis.

Objective: We aim to evaluate the efficacy and safety of blinatumomab for the treatment of post-transplant relapse patients with acute lymphoblastic leukemia (ALL).

Methods: The search was conducted using several databases including the PubMed, Cochrane Library, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang Data Knowledge Service Platform to collect clinical studies related to blinatumomab. The primary outcome measures were complete remission (CR), 1-year overall survival (OS), 2-year OS, median OS and adverse events (AEs).

Synergetic Optimization via Indium and Rare Metal Yttrium Co-doping in GeTe Results in High Power Factor and Excellent Thermal Performance.

Excess intrinsic Ge vacancies in GeTe materials lead to excessively high hole concentration and high thermal conductivity, producing poor thermoelectric performance. Here, synergistic control and optimization of the thermoelectric transport properties and microstructure of GeTe-based materials were achieved through co-doping with In and rare earth element Y, resulting in a significant enhancement of thermoelectric performance. The GeInYTe sample reached a ZT of 1.

Primary mesenchymal tumors of the prostate:F FDG PET/CT findings.

Background: Primary mesenchymal tumors of the prostate are very rare, and there is no systematic report on fluorine-18-fluorodeoxyglucose positron emission tomography (F-FDG PET/CT). The aim of this research was to characterize mesenchymal tumors of the prostate on F-FDG PET/CT.

Results: We included 13 patients with pathologically confirmed mesenchymal neoplasms of the prostate.

Pharmacokinetic Positron Emission Tomography Imaging of an Optimized CD38-Targeted Ga-Labeled Peptide in Multiple Myeloma: A Pilot Study.

Multiple myeloma (MM) is an incurable disease characterized by its clinical and prognostic heterogeneity. Despite conventional chemotherapy and autologous hematopoietic stem cell transplantation, the management of relapsed and refractory MM disease poses significant challenges, both medically and socioeconomically. CD38, highly expressed on the surface of MM cells, serves as a distinct tumor biological target in MM.