Structural analysis and treatment of acute liver injury of polysaccharides from the .

Objective: To investigate the therapeutic effects of the PRAC on acute liver injury and its potential as an ingredient in drugs and nutraceuticals.

Methods: Microwave-assisted extraction technology combined with Box-Behnken model combined with the three kinds of artificial neural networks was used to optimize PRAC extraction process. Characterize the structure and composition of PRAC.

[Research progress of JAK/STAT signaling pathway in rheumatoid arthritis pain].

Rheumatoid arthritis (RA) is a common systemic inflammatory autoimmune disease characterized by synovitis and bone destruction. Its clinical characteristics are mainly joint pain, swelling, stiffness and joint deformity. Due to the poor efficacy of both drug and non-drug therapies, RA can significantly impact patients' quality of life and increase personal and socioeconomic burdens.

[Research progress on the role and mechanism of endothelin-1 in pain].

Endothelin-1 is a peptide derived from endothelial cells, consisting of 21 amino acid residues. In recent years, research has found that endothelin-1 not only plays a key role in vascular tone regulation but also participates in the occurrence and development of various types of pathological pain, including inflammatory pain, neuropathic pain, and cancer pain. Endothelin-1 binds to its receptors and activates multiple signaling pathways such as protein kinase C, calcium ion channels, and the phosphoinositide pathway, thereby influencing neuronal excitability and nociceptive information transmission.

Identification of CMY-190, a novel chromosomally encoded AmpC β-lactamase, and plasmid-encoded KPC-2 in a clinical isolate of .

This study investigates the antibiotic resistance phenotype and genotype of strain YS01, isolated from a peritoneal effusion sample, focusing on both chromosomal and plasmid-mediated resistance mechanisms to inform clinical antibiotic therapy. Our results reveal the presence of the chromosomally encoded β-lactamase CMY-190 and the plasmid-encoded carbapenemase KPC-2, which confer resistance to cephalosporins and carbapenems, respectively. CMY-190 exhibits substrate and inhibition profiles similar to AmpC β-lactamases and shares 88.

Development of Shaped MIL-100(Fe) Granules for High-Performing Adsorption Desalination: From Formulation Optimization to System Test.

Adsorption desalination (AD) driven by low-grade renewable energy or waste heat is a sustainable solution to the water crisis. Recently, metal-organic frameworks (MOFs) with excellent water adsorption performances have been recognized as some of the most promising candidates for AD. However, previous studies mainly focused on MOFs in powder form, causing pipe clogging and a drastic pressure drop, which inspire the development of shaped MOFs for industrial use.

YAP1 mediates the dimensional and chemical coordination of immunoregulation and therapy in extensively passaged mesenchymal stem cells.

Mesenchymal stem cells (MSCs) possess potent immunomodulatory capability, but occasionally, clinical application of MSCs is hindered by compromised cell functionality and insufficient therapeutic efficacy. Here, well-established mouse models of dextran sulfate sodium (DSS)-induced colitis and streptozotocin (STZ)-induced type 1 diabetes (T1D) were used to evaluate therapeutic immunomodulatory effects of human umbilical cord-derived MSCs. MSCs were examined at the fifth (P5) and the fifteenth (P15) passages, and three-dimensional (3D) culture was conducted by Matrigel incorporation.

AUGMENTED DOUBLY ROBUST POST-IMPUTATION INFERENCE FOR PROTEOMIC DATA.

Quantitative measurements produced by mass spectrometry proteomics experiments offer a direct way to explore the role of proteins in molecular mechanisms. However, analysis of such data is challenging due to the large proportion of missing values. A common strategy to address this issue is to utilize an imputed dataset, which often introduces systematic bias into downstream analyses if the imputation errors are ignored.

TRPV3 in skin thermosensation and temperature responses.

Human skin, as a sophisticated sensory organ, is able to detect subtle changes in ambient temperature. This thermosensory capability is primarily mediated by temperature-sensitive TRP channels expressed in both sensory neurons and keratinocytes. Among these, TRPV3, which responds to warm temperatures and plays a crucial role in various skin functions, is particularly notable.

EXIT Charts for Low-Density Algebra-Check Codes.

This paper focuses on the Low-Density Algebra-Check (LDAC) code, a novel low-rate channel code derived from the Low-Density Parity-Check (LDPC) code with expanded algebra-check constraints. A method for optimizing LDAC code design using Extrinsic Information Transfer (EXIT) charts is presented. Firstly, an iterative decoding model for LDAC is established according to its structure, and a method for plotting EXIT curves of the algebra-check node decoder is proposed.

Association between red blood cell distribution width and genetic risk in patients with rheumatoid arthritis: a prospective cohort study and Mendelian randomization analysis.

Objective: Elevated red blood cell distribution width (RDW) is associated with increased risk of rheumatoid arthritis (RA), but the potential interactions of RDW with genetic risk of incident RA remain unclear. This study aimed to investigate the associations between RDW, genetics, and the risk of developing RA.

Methods: We analysed data from 145,025 healthy participants at baseline in the UK Biobank.

The Gut Microbiota Affects Anti-TNF Responsiveness by Activating the NAD Salvage Pathway in Ulcerative Colitis.

Approximately 50% of the patients with ulcerative colitis (UC) are primarily nonresponsive to anti-tumor necrosis factor (TNF) therapy or lose their responsiveness over time. The gut microbiota plays an important role in the resistance of UC to anti-TNF therapy; however, the underlying mechanism remains unknown. Here, it is found that the transplantation of gut fecal microbiota from patients with UC alters the diversity of the gut microbiota in dextran sulfate sodium-induced colitis mice and may affect the therapeutic responsiveness of mice to infliximab.

HDL-C is inversely associated with the incidence of osteoarthritis among the USA: evidence from the NHANES program of 1999-2020.

Osteoarthritis (OA) has been the most common arthritis affecting public health all over the world. Previous experimental research reported that increased low-density lipoprotein cholesterol, along with decreased high-density lipoprotein cholesterol may be associated with increased ectopic bone formation and possible knee OA, while clinical evidence is absent. This study aimed to investigate the association between blood high-density lipoprotein cholesterol (HDL-C) and OA.

Asymptotic Distribution-Free Independence Test for High Dimension Data.

Test of independence is of fundamental importance in modern data analysis, with broad applications in variable selection, graphical models, and causal inference. When the data is high dimensional and the potential dependence signal is sparse, independence testing becomes very challenging without distributional or structural assumptions. In this paper, we propose a general framework for independence testing by first fitting a classifier that distinguishes the joint and product distributions, and then testing the significance of the fitted classifier.

Correlation of volatile organic chemical exposure with uric acid metabolism among US population: A cross-sectional study from NHANES program.

Volatile organic chemicals (VOC) have been identified as hazardous pollutants impairing human health. While whether the VOC exposure was associated with hyperuricemia is yet clarified. All the data was acquired from 6 survey cycles of the National Health and Nutrition Examination Survey (NHANES) program (2005-2006, 2011-2012, 2013-2014, 2015-2016, 2017-2018, 2017-2020).

Effects of 1-Methylcyclopropene Treatment on Postharvest Quality and Metabolism of Different Kiwifruit Varieties.

The kiwifruit () is an important nutritional and economic fruit crop. However, the short edible window period of kiwifruit has seriously affected its market value. 1-Methylcyclopropene (1-MCP), as a novel ethylene inhibitor, is widely applied to delay fruit ripening and senescence.

Transcatheter Edge-to-Edge Repair of the Mitral Valve in Four Dogs: Preliminary Results Regarding Efficacy and Safety.

Mitral valve disease is a common heart disease in dogs. The aim of this study was to describe the cases of dogs that underwent mitral valve repair via a V-clamp device and to provide long-term follow-up data on cardiac function after mitral valve repair. Four dogs with mitral valve regurgitation who experienced coughing and dyspnea underwent surgical mitral valve repair between December 2023 and March 2024.

Ubiquitin-Specific Protease 1 Promotes Bladder Cancer Progression by Stabilizing c-MYC.

Background: Ubiquitination is an important post-transcriptional modification crucial for maintaining cell homeostasis. As a deubiquitination enzyme, ubiquitin-specific protease 1 (USP1) is associated with tumor progression; however, its role in bladder cancer is unknown. This study aimed to analyze USP1 expression and study its roles in bladder cancer.

[The role of the tryptophan-kynurenine pathway in neuropathic pain].

The kynurenine pathway (KP) is the main metabolic pathway of tryptophan in the diet. Existing research has shown that KP plays a key role in the pathogenesis of various diseases. It has been demonstrated that kynurenine metabolic enzymes, such as indoleamine 2,3-dioxygenase (IDO) and kynurenine monooxygenase (KMO), are involved in various types of pain, particularly the occurrence and development of neuropathic pain.

Efficient electron transport at the perovskite nanodots interface facilitates CO photoreduction.

How to achieve controllable preparation of heterostructure and in-situ optimize the interface and internal electron transfer by a fast and economic synthesis method has become a big challenge in the practical application of photocatalysis. Herein, an island-shaped SrTiO (STO) perovskite nanodots and TiO (T) compounded S-scheme SrTiO/TiO (ST) heterostructure was successfully developed. During the millisecond reaction process, the decomposed Sr penetrated into the TiO lattice causing the lattice expansion and inducing local atomic rearrangements, resulting in the generation of STO phase.

Exploring tumor microenvironment in molecular subtyping and prognostic signatures in ovarian cancer and identification of SH2D1A as a key regulator of ovarian cancer carcinogenesis.

Introduction: A deadly gynecological cancer, ovarian cancer (OV), has a poor prognosis because of late-stage diagnosis and few targeted therapies. Addressing the tumor microenvironment (TME) in solid tumors has shown promise since it is crucial in promoting cancer progression.

Methods: We obtained bulk RNA-seq data from TCGA-OV, GSE26712, GSE102073, and ICGC cohorts, as well as scRNA-seq data from EMTAB8107, GSE118828, GSE130000, and GSE154600 cohorts using the TISCH2 database.

Developing a mouse model of human coronavirus NL63 infection: comparison with rhinovirus-A1B and effects of prior rhinovirus infection.

Human coronavirus (HCoV)-NL63 causes respiratory tract infections in humans and uses angiotensin-converting enzyme 2 (ACE2) as a receptor. We sought to establish a mouse model of HCoV-NL63 and determine whether prior rhinovirus (RV)-A1B infection affected HCoV-NL63 replication. HCoV-NL63 was propagated in LLC-MK2 cells expressing human ACE2.